Results 1 to 10 of about 181,705 (382)

Revised renal stratification and progression models for predicting long-term renal outcomes in immunoglobulin light chain amyloidosis

Haematologica
Renal prognosis in light-chain amyloidosis (AL) is determined by categorizing patients into three renal stages at diagnosis and assessing Renal Response or Renal Progression following chemotherapy after 6 months.
Muhammad Umaid Rauf, Steven Law, Marisa Santostefano, Philip N. Hawkins, Aviva Petrie, Francesco Cappelli, Federico Perfetto, Yousuf Razvi, Aldostefano Porcari, Sriram Ravichandran, Adam Ioannou, Joshua Bomsztyk, Alessia Argirò, Costanza Gaudio, Elisabetta Antonioli, Alessandro Barilaro, Marco Delsante, Vittorio Di Maso, Maria G. Chiappini, Olabisi Ogunbiyi, Oliver C. Cohen, Ana Martinez-Naharro, Carol Whelan, Helen J. Lachmann, Ashutosh D. Wechalekar, Federico Alberici, Marianna Fontana, Marco Allinovi, Julian D. Gillmore   +28 more
doaj   +1 more source

Right Ventricle Outflow Obstruction in Biventricular Hypertrophic Cardiomyopathy in Amyloidosis [PDF]

, 2017
Light-chain (AL) amyloidosis is the most common type of amyloidosis; cardiac involvement is rare but has a poor prognosis. Biventricular hypertrophic cardiomyopathy is an exceptional finding in amyloidosis and its association with obstructive right ...
Cherti, Mohammed, Kourireche, Najla, Oukerraj, Latifa, Sanoussi, Hamza   +3 more
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Electromechanical dissociation of left atrium in patients with Cardiac Amyloidosis by Magnetic Resonance: Prognostic and clinical correlates

International Journal of Cardiology: Heart & Vasculature, 2020
Objectives: Left atrial (LA) function is an important marker of hemodynamic status in cardiac amyloidosis (CA), and its characterization may provide relevant prognostic information.
Giovanni Donato Aquaro, Sofia Morini, Chrysanthos Grigoratos, Giulia Taborchi, Gianluca Di Bella, Raffaele Martone, Elisa Vignini, Michele Emdin, Iacopo Olivotto, Federico Perfetto, Francesco Cappelli   +10 more
doaj  

Proteomic Analysis for the Diagnosis of Fibrinogen Aα-chain Amyloidosis

Kidney International Reports, 2019
Introduction: Hereditary fibrinogen Aα-chain (AFib) amyloidosis is a relatively uncommon renal disease associated with a small number of pathogenic fibrinogen Aα (FibA) variants; wild-type FibA normally does not result in amyloid deposition.
Graham W. Taylor, Janet A. Gilbertson, Rabya Sayed, Angel Blanco, Nigel B. Rendell, Dorota Rowczenio, Tamer Rezk, P. Patrizia Mangione, Diana Canetti, Paul Bass, Philip N. Hawkins, Julian D. Gillmore   +11 more
doaj  

The Amyloidosis Forum: a public private partnership to advance drug development in AL amyloidosis

Orphanet Journal of Rare Diseases, 2020
Background Immunoglobulin light chain (AL) amyloidosis is a rare, multi-systemic disorder characterized by two disease processes: an underlying plasma cell dyscrasia that provides the source of pathologic light chains, and the resulting organ dysfunction
The Inaugural Amyloidosis Forum Panelists, Isabelle Lousada   +1 more
doaj   +1 more source

The relationship between amyloid structure and cytotoxicity [PDF]

, 2014
Self-assembly of proteins and peptides into amyloid structures has been the subject of intense and focused research due to their association with neurodegenerative, age-related human diseases and transmissible prion diseases in humans and mammals. Of the
Marchante, Ricardo, Marshall, Karen E, Serpell, Louise C, Xue, Wei-Feng   +3 more
core   +1 more source

Magnetization transfer ratio quantifies polyneuropathy in hereditary transthyretin amyloidosis

Annals of Clinical and Translational Neurology, 2020
Objective To quantify peripheral nerve lesions in symptomatic and asymptomatic hereditary transthyretin amyloidosis with polyneuropathy (ATTRv‐PNP) by analyzing the magnetization transfer ratio (MTR) of the sciatic nerve, and to test its potential as a ...
Jennifer Kollmer, Ute Hegenbart, Christoph Kimmich, Ernst Hund, Jan C. Purrucker, John M. Hayes, Stephen I. Lentz, Georges Sam, Johann M. E. Jende, Stefan O. Schönland, Martin Bendszus, Sabine Heiland, Markus Weiler   +12 more
doaj   +1 more source

'Care and Prevent': rationale for investigating skin and soft tissue infections and AA amyloidosis among people who inject drugs in London. [PDF]

, 2018
BACKGROUND: Skin and soft tissue infections (SSTIs) are a leading cause of morbidity and mortality among people who inject drugs (PWID). International data indicate up to one third of PWID have experienced an SSTI within the past month.
AF Coull, B Pieper, B Pieper, B Thompson, C Irish, C McGowan, Catherine R. McGowan, D Ciccarone, D Ciccarone, D Ciccarone, D Lewer, D. Ciccarone, DC Des Jarlias, DS Fink, EL Murphy, G. Gilchrist, HJ Lachmann, HL Hillege, HLF Cooper, IA Binswanger, J Corbin, J Creswell, J Scott, J. Dunn, J. Scott, K Charmaz, K O'Brien, K Race, K. O’Brien, LS May, M Harris, M Harris, M Harris, M Madden, M Marks, M. Harris, M. McCusker, MM Brett, MT Wright, N Robinowitz, National Institute for Health Research, National Treatment Agency for Substance Misuse, O Jung, PJ Summers, Public Health England, Public Health England, R. Brathwaite, S Jafari, S Larney, S Liangpunsakul, SJ Palfreyman, T Farmer, T Tillin, TA Takahashi, V Hope, V. Hope, VD Hope, VD HOPE, W Hoy   +58 more
core   +9 more sources

Update on treatment of light chain amyloidosis

Haematologica, 2014
Light chain amyloidosis is the most common type of amyloidosis as a consequence of protein misfolding of aggregates composed of amyloid fibrils. The clinical features are dependent on the organs involved, typically cardiac, renal, hepatic, peripheral and
Shameem Mahmood, Giovanni Palladini, Vaishali Sanchorawala, Ashutosh Wechalekar   +3 more
doaj   +1 more source

Folding of small disulfide-rich proteins : clarifying the puzzle [PDF]

, 2006
Premi a l'excel·lència investigadora. Àmbit de les Ciències Experimentals. 2008The process by which small proteins fold to their native conformations has been intensively studied over the last few decades.
Apuy, Arolas, Arolas, Arolas, Arolas, Baneyx, Bardwell, Cemazar, Cemazar, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chatrenet, Creighton, Creighton, Creighton, Creighton, Creighton, Daggett, Daly, Darby, Dobson, Ellgaard, Francesc X. Aviles, Fuller, Gehrmann, Goldberg, Goldenberg, Heitz, Hogg, Houry, Joan L. Arolas, Jui-Yoa Chang, Klein-Seetharaman, Kortemme, Kuhlman, Laity, Li, Lu, Matagne, Narayan, Narayan, Narayan, Narayan, Onuchic, Permyakov, Ross, Ruoppolo, Ruoppolo, Salamanca, Salvador Ventura, Scheraga, Shimotakahara, Shin, van den Berg, van den Berg, van Mierlo, van Mierlo, Venhudova, Wedemeyer, Weissman, Welker, Welker, Wu, Yang, Zavodszky   +73 more
core   +2 more sources