The Amyloidosis Forum: a public private partnership to advance drug development in AL amyloidosis [PDF]
Orphanet Journal of Rare Diseases, 2020 Background Immunoglobulin light chain (AL) amyloidosis is a rare, multi-systemic disorder characterized by two disease processes: an underlying plasma cell dyscrasia that provides the source of pathologic light chains, and the resulting organ dysfunction
The Inaugural Amyloidosis Forum Panelists +1 more
doaj +3 more sources
Case Report and Literature Review of Cardiac Amyloidosis: A Not-So-Rare Cause of Heart Failure [PDF]
, 2023 Restrictive cardiomyopathy secondary to cardiac amyloidosis is an underdiagnosed cause of heart failure and it is associated with significant morbidity and mortality.
Alexandre, André +3 more
core +1 more source
Senile Systemic Amyloidosis: Clinical Features at Presentation and Outcome [PDF]
, 2013 Background Cardiac amyloidosis is a fatal disease whose prognosis and treatment rely on identification of the amyloid type. In our aging population transthyretin amyloidosis (ATTRwt) is common and must be differentiated from other amyloid types.
Banypersad, SM +15 more
core +1 more source
Renal AA-amyloidosis in intravenous drug users - a role for HIV-infection? [PDF]
, 2012 Background: Chronic renal disease is a serious complication of long-term intravenous drug use (IVDU). Recent reports have postulated a changing pattern of underlying nephropathy over the last decades.
Grützmacher, Peter +17 more
core +2 more sources
Blood Cancer Journal, 2022 Effective systemic therapies suppress toxic light chain production leading to an increased proportion of patients with light chain (AL) amyloidosis who survive longer albeit with end-stage renal disease.
Andrea Havasi +21 more
doaj +1 more source
A case report of pulmonary amyloidosis recognized by detection of AA amyloid exclusively in alveolar macrophages [PDF]
, 2020 Amyloidosis is a rare condition in which tissue deposits of inert fibrillar protein result in organ damage and dysfunction. There are several types of amyloid fibrils.
Bychkov, Andrey +9 more
core +1 more source
Experimental approaches to study cerebral amyloidosis in a transgenic mouse model of Alzheimer's disease [PDF]
, 2004 Misfolding, aggregation and the accumulation of proteins in the brain are common characteristics of diverse age-related neurodegenerative diseases. Each of these neurodegenerative diseases is associated with abnormalities in the folding of a different
Meyer-Lühmann, Melanie
core +1 more source
Cerebral amyloidosis in a transgenic mouse model of Alzheimer's disease : impact and therapy [PDF]
, 2003 Senile dementia is a diagnostic category that includes all types of cognitive and memory impairments that occur in the elderly. Alzheimer’s disease (AD) is the most common form of dementia, which is characterized by progressive impairments in memory ...
Boncristiano, Sonia
core +1 more source
Clinical Amyloid Typing by Proteomics: Performance Evaluation and Data Sharing between Two Centres
Molecules, 2021 Amyloidosis is a relatively rare human disease caused by the deposition of abnormal protein fibres in the extracellular space of various tissues, impairing their normal function. Proteomic analysis of patients’ biopsies, developed by Dogan and colleagues
Diana Canetti +12 more
doaj +1 more source
Hepatology Communications, EarlyView., 2022 Abstract Hepatocellular adenomas (HCAs) are benign liver tumors associated with bleeding or malignant transformation. Data on the indication for surgery are scarce. We analyzed indications and outcome of patients operated for HCAs < 50 mm compared to HCAs ≥ 50 mm. Changes in final postoperative diagnosis were assessed.
Martijn P. D. Haring +70 more
wiley +1 more source