Results 241 to 250 of about 98,806 (295)

Blood gene expression network expression strongly relates to brain amyloid burden

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Amyloid deposition occurs decades before symptoms emerge in Alzheimer's disease (AD). We leveraged blood transcriptomics and positron emission tomography (PET) measures of amyloidosis to identify gene networks in the blood that relate to amyloid burden in the brain. METHODS Whole‐blood RNA sequencing and amyloid PET were leveraged
Vaibhav A. Janve, Mabel Seto, Reisa A. Sperling, Paul S. Aisen, Robert A. Rissman, Mary Ellen I. Koran, Logan Dumitrescu, Rachel F. Buckley, Timothy J. Hohman, A4 and LEARN Study Group   +9 more
wiley   +1 more source

Impact of early minimal residual disease assessment on the outcomes of patients with systemic light chain amyloidosis. [PDF]

Ann Med
Li X, Chen M, Liu J, Gu J, Huang B, Kuang L, Li J.   +6 more
europepmc   +1 more source

White matter hyperintensity modulates the amyloid‐tau‐cognition association and anti‐amyloid treatment efficacy in asymptomatic older adults

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION White matter hyperintensities (WMH), a key imaging biomarker of small vessel injury, may play a complex role in Alzheimer's disease (AD). We hypothesize that WMH not only directly contributes to cognitive decline but also moderates the relationship among AD pathology, treatment, and cognitive decline.
Zixuan Lin, Yiwen Hong, Yizhe Hu, Qian Xiao, Shin‐Lei Peng, Dan Wu, Tengfei Guo, Dengrong Jiang   +7 more
wiley   +1 more source

Functional Capacity Evaluation and Rehabilitation Strategies in Cardiac Amyloidosis: A Comprehensive Review. [PDF]

J Clin Med
Plevritaki A, Volaklis K, Nakou E, Davos C, Kopidakis I, Kallergis E, Savva E, Simantirakis E, Aleksova A, Marketou M.   +9 more
europepmc   +1 more source

APOE, ABCA7, and RASGEF1C are associated with earlier onset of amyloid deposition from more than 4000 harmonized positron emission tomography images

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION New methods estimate amyloid positivity onset age (EAOA) from amyloid positron emission tomography (PET). We explore the genetics of EAOA to identify molecular factors underlying the earliest Alzheimer's disease (AD) changes. METHODS Harmonized amyloid PET data from 4216 participants were used in genome‐wide survival, tissue ...
Tonnar Castellano, Ting Chen Wang, Emma Nolan, Yiyang Wu, Mengna Zhang, Michelle Clifton, Vaibhav A. Janve, Alaina Durant, Alexis Regelson, Karly Cody, Theresa Harrison, Corinne D. Engelman, William Jagust, Marilyn Albert, Sterling Johnson, Susan M. Resnick, Reisa Sperling, Murat Bilgel, Andrew Saykin, Badri Vardarajan, Richard Mayeux, Alzheimer's Disease Neuroimaging Initiative, Tobey Betthauser, David A. Bennett, Julie Schneider, Phil De Jager, Vilas Menon, Duygu Tosun, Elizabeth Mormino, Derek B. Archer, Logan Dumitrescu, Timothy J. Hohman, Mary Ellen Koran   +32 more
wiley   +1 more source

Improvement of Low-Dose Abrocitinib-Resistant Lichen Amyloidosis with Dupilumab: Two Case Reports. [PDF]

Clin Cosmet Investig Dermatol
Zhang W, Mao D, Zhou C, Wen G.
europepmc   +1 more source

Systemic Piezo1 activation improves cerebrovascular function in Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Cerebral blood flow (CBF) reductions and impaired functional hyperemia (FH) are early features of Alzheimer's disease (AD) that contribute to disease progression. Here, we investigated whether systemic activation of the mechanosensitive ion channel Piezo1 affects cerebrovascular deficits in an AD mouse model.
Zeynab Tabrizi, Xin Rui Lim, Supriya Chakraborty, Osama F. Harraz, Oliver Bracko   +4 more
wiley   +1 more source

Correction to "Unmasking Upper Airway Obstruction: A Case of Tracheobronchial Amyloidosis". [PDF]

Respirol Case Rep
europepmc   +1 more source

Primary Localized Conjunctival Amyloidosis Mimicking Lymphoma. [PDF]

Beyoglu Eye J
Coskun B, Ozhamam EU, Yuksel N.
europepmc   +1 more source

Cutaneous light chain amyloidosis and erythema elevatum diutinum as the presenting features of IgA monoclonal gammopathy: a rare case report and comprehensive literature review. [PDF]

Ann Hematol
Han B, Zhou J, Liu H, Li S, Wang H.
europepmc   +1 more source