Results 201 to 210 of about 13,480 (279)

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

Angewandte Chemie, EarlyView.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee, Sumin Son, Jeong Yeon Yoo, Ji Hyae Lee, Meehyun Chun, Seung Bum Park   +5 more
wiley   +2 more sources

How It Started...How It Is Going: From All-Polymer Batteries to Living Fibers-A Journey through Biobased Innovation. [PDF]

Nano Lett
Nyström G.
europepmc   +1 more source

Record Dissymmetry in Vibrational Optical Activity: Combining Vibronic Coupling and Aggregation in Cobalt(II) Camphorate Complexes

Angewandte Chemie, EarlyView.
The cobalt(II) bis(trifluoroacetylcamphorate) scaffold exhibits versatile coordination chemistry with solvent‐driven ligand exchange and geometrical rearrangements, associated with unique chiroptical properties. Microcrystalline suspension of [Co(tfc)2(CH3CN)2] revealed the largest VCD dissymmetry factor ever reported (g ≈ 0.2 at 1600 cm−1), arising ...
Gianmarco Papi, Massimo Guelfi, Stefano Zacchini, Fabio Marchetti, Gennaro Pescitelli   +4 more
wiley   +2 more sources

From Pathology to Materials Science and Engineering: Harnessing the Amyloid State for Biotechnological Applications. [PDF]

ACS Appl Mater Interfaces
Fallot LB, Natarajan C, Anderson CA, Nagelli EA, Burpo FJ, Limbocker R.   +5 more
europepmc   +1 more source

Metal Oxides Catalyze Formation of Dehydroamino Acids by Phosphate β‐Elimination Under Physiological Conditions

Angewandte Chemie, EarlyView.
Dehydroamino acids (DHAA) are atypical electrophilic sites that lead to crosslinked proteins in Alzheimer's disease (AD) brains. No catalyst for their formation has been known in humans. We report that metal oxides catalyze β‐elimination of phosphoserine and phosphothreonine in model peptides at pH 7.5°C and 37°C, yielding DHAAs.
Samuel W. Markovich, Brian L. Frey, Mark Scalf, Lloyd M. Smith   +3 more
wiley   +2 more sources

The cytoplasmic protein YedX is a potent inhibitor of CsgA amyloid assembly in E. coli. [PDF]

J Biol Chem
Gurnani B, Jain N.
europepmc   +1 more source

Reply to “CSF Amyloid‐β Risk Stratification in CAA: A Missing Link for Anti‐Amyloid Therapy Safety”

Annals of Neurology, EarlyView.
Philipp Arndt, Stefanie Schreiber
wiley   +1 more source

The Many Facets of Metal-Binding Peptides. [PDF]

Chemistry
Mathieu E, Hureau C.
europepmc   +1 more source

Amyloid Disease

International Journal of Clinical Practice, 1954
openaire   +2 more sources