Results 221 to 230 of about 13,480 (279)

Indole‐3‐Acetic Acid Protects Bovine Hepatocytes Against Palmitic Acid‐Induced Lipid Accumulation and ER Stress Through SIRT3

Animal Research and One Health, EarlyView.
Cows with ketosis during the perinatal period often experience damage to the liver, a core metabolic organ, thereby exacerbating the disease's inherent vicious cycle. This study indicates that serum 3‐IAA concentrations were reduced in ketotic cows and show a significant negative correlation with hepatic TG content.
Dandan Qi, Chenchen Zhao, Guiying Li, Jinxia Li, Menglin Liu, Fanrong Kong, Enzhu Li, Jie Gao, Wenqi Liao, Akos Kenez, Wenwen Gao, Yuxiang Song, Xiliang Du, Guowen Liu, Xinwei Li, Lin Lei   +15 more
wiley   +1 more source

Standardization of cross-site biophysical studies of bovine insulin amyloids is challenged by structural polymorphism. [PDF]

Eur Biophys J
Nyström S, Odino D, Relini A, Canale C, Parlato R, Knelissen Y, Lasorsa A, Roos WH, van der Wel PCA, Hoffmann SV, Jones NC, van Hemelryck V, Waeytens J, Raussens V, Hammarström P.   +14 more
europepmc   +1 more source

Cross‐Species Single‐Cell Comparative Analysis Reveals Gluconeogenic Features of Hepatocytes in Ruminants

Animal Research and One Health, EarlyView.
In this study, we used cross‐species comparisons to identify ruminant hepatocyte features. We also identified potential genes and TFs involved in coordinating gluconeogenesis in ruminant hepatocytes. By integrating single‐cell data with population genetic analyses, we further identified candidate genetic variation in glucose metabolism and ...
Yaqi Zhou, Wuqiang Huo, Yingran Liu, Yihang Liu, Fei Wang, Tao Shi, Yu Jiang   +6 more
wiley   +1 more source

The impact of physiological oxidants on triggering amyloid formation of the cell cycle regulator protein p16^INK4A. [PDF]

Protein Sci
Smith BR, Magon NJ, Sethi A, Gray SG, Heath SG, Morris VK, Göbl C.   +6 more
europepmc   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Application of artificial intelligence for the prediction of amyloidoses. [PDF]

Neural Regen Res
Gonay V, Dunne MP, Kajava AV.
europepmc   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Structural and morphological dynamics of "on-path" and "off-path" oligomers of human islet amyloid polypeptide. [PDF]

Protein Sci
Warren D, Sitton J, Kurouski D.
europepmc   +1 more source

Bacterial Amyloids as Hubs for Nucleic Acid Interactions: Implications and Mechanisms. [PDF]

Int J Mol Sci
Bloch S, Loutfi G, Moroy G, Sinden RR, Węgrzyn G, Arluison V.   +5 more
europepmc   +1 more source