Results 1 to 10 of about 148,501 (250)
Amyotrophic lateral sclerosis [PDF]
Nature Reviews Disease Primers, 2022 Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized by the degeneration of both upper and lower motor neurons, which leads to muscle weakness and eventual paralysis. Until recently, ALS was classified primarily within the neuromuscular domain, although new imaging and neuropathological data have indicated the ...
E. Feldman +6 more
semanticscholar +10 more sources
Chemical Reviews, 2021 Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting either the central nervous system or a variety of peripheral tissues.
Alfonso De Simone +2 more
exaly +2 more sources
Amyotrophic Lateral Sclerosis. [PDF]
New England Journal of Medicine, 2017 From the Department of Neurology, University of Massachusetts Medical School, Worcester (R.H.B.); and the Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, King’s College London, London (A.A.-C.).
Robert H. Brown, A. Al-Chalabi
semanticscholar +13 more sources
Amyotrophic lateral sclerosis [PDF]
Orphanet Journal of Rare Diseases, 2009 Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by progressive muscular paralysis reflecting degeneration of motor neurones in the primary motor cortex, corticospinal tracts, brainstem and spinal cord.
Leigh P Nigel, Wijesekera Lokesh C
doaj +3 more sources
Associations of cachexia and frailty with amyotrophic lateral sclerosis [PDF]
Scientific ReportsIn the present study, we investigated the associations of cachexia (loss of muscle, weight and fat) and frailty (loss of weight and muscle) status with the risk of developing amyotrophic lateral sclerosis, because these specific terms are rarely used in ...
Tracy L. Peters +6 more
doaj +2 more sources
Ethics in Progress, 2022 This paper aims at analysing the evolution of palliative care in the international context and their role in the path of care for the patient and the family.
Stefania Bastianello +1 more
doaj +1 more source
Scientific Reports, 2021 Children that have a parent with Amyotrophic Lateral Sclerosis (ALS) suffer from the progressive loss of their beloved ones. During the COVID-19 pandemic, the difficulties faced by these children have increased.
Ines Testoni +5 more
doaj +1 more source
H63D CG genotype of HFE is associated with increased risk of sporadic amyotrophic lateral sclerosis in a single population [PDF]
Journal of Integrative Neuroscience, 2020 This paper describes the genetic etiology of sporadic amyotrophic lateral sclerosis in a single population. Polymerase chain reaction-restriction fragment length polymorphism and DNA sample sequencing of 3 common HFE gene variants (C282Y and H63D and ...
Qing-Qing Zhang, Hong Jiang, Chun-Yan Li, Ya-Ling Liu, Xin-Ying Tian
doaj +1 more source
Nature reviews. Drug discovery, 2022 Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of motor neurons. As with all major neurodegenerative disorders, development of disease-modifying therapies has proven challenging for multiple reasons. Nevertheless, ALS
R. Mead +4 more
semanticscholar +1 more source
The landscape of cognitive impairment in superoxide dismutase 1-amyotrophic lateral sclerosis
Neural Regeneration Research, 2023 Although mutations in the superoxide dismutase 1 gene account for only a minority of total amyotrophic lateral sclerosis cases, the discovery of this gene has been crucial for amyotrophic lateral sclerosis research. Since the identification of superoxide
Ilaria Martinelli +6 more
doaj +1 more source