Results 161 to 170 of about 84,970 (256)

Capturing Financial Burden Concerns in an ALS Multidisciplinary Clinic

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Amyotrophic lateral sclerosis (ALS) is associated with substantial financial burden. How financial concerns are documented or addressed in ALS multidisciplinary clinics (MDC) is unclear. We aimed to characterize financial concerns among people living with ALS (pALS) and how they are identified and documented by ...
Nikhita Pathapati, Minh Nguyen, Jaden Ju, Mahita Maddukuri, John Kiehl, Elizabeth Kvale, Aaron P. Thrift, Sarah Berth, Astrid Grouls   +8 more
wiley   +1 more source

Long-Term Tofersen in SOD1 Amyotrophic Lateral Sclerosis. [PDF]

JAMA Neurol
Miller TM, Cudkowicz ME, Shaw PJ, Genge A, Sobue G, Bucelli RC, Chiò A, Van Damme P, Ludolph AC, Glass JD, Andrews JA, Babu S, Benatar M, McDermott CJ, Salachas F, Bruneteau G, Al-Chalabi A, Amorin M, Nestorov I, Graham D, Lin L, Sun P, McNeill M, Malek S, Inra J, Garafalo S, Fradette S, VALOR and OLE Working Group.   +27 more
europepmc   +1 more source

“Abductor Sparing”: A New Selective Involvement in ALS

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Various signs of selective muscle involvement have been reported in amyotrophic lateral sclerosis (ALS) but such studies for the lower limbs are scarce. We formed a preliminary impression that hip abductors (Ab) are often preserved in ALS.
Amuro Kondo, Keiichi Hokkoku, Takamichi Kanbayashi, Takahiro Nakayama, Takuya Sasaki, Hiromasa Matsuno, Yasuyuki Iguchi, Toshio Fukutake, Tetsuo Ando, Tsutomu Kamiyama, Pyou Kim, Takahiro Hasegawa, Yuki Hatanaka, Shunsuke Kobayashi, Masahiro Sonoo   +14 more
wiley   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

Safety and Efficacy of PrimeC in Amyotrophic Lateral Sclerosis: The PARADIGM Randomized Clinical Trial.

JAMA Neurol
Cudkowicz M, Drory VE, Chio A, Lunetta C, Shoesmith C, van Eijk RPA, Salomon-Zimri S, Shtossel D, Kerem N, Shapira G, Shomron N, Russek-Blum N, Tracik F, Rosenfeld J, Shefner J.   +14 more
europepmc   +1 more source

Associations influencing quality of life in caregivers of patients with amyotrophic lateral sclerosis: a stress-process model approach. [PDF]

Qual Life Res
Turkmenel N, Uskun E.
europepmc   +1 more source

Mesenchymal Stem Cells From a Klinefelter Syndrome Patient: Functional Characterization and Therapeutic Implications

Andrology, EarlyView.
ABSTRACT Background Cell therapy, particularly those utilizing mesenchymal stem/stromal cells (MSCs), is gaining traction as a therapeutic option for regenerative treatment in patients with limited therapeutic options. Although the safety of MSC‐based interventions is well established, uncertainties remain regarding how genetic abnormalities and ...
Marzena Zychowicz, Wioletta Lech, Anna Figiel‐Dabrowska, Marta Kot, Magdalena Murzyn, Natalia Malawska, Barbara Pienkowska‐Grela, Zuzanna Sandowska‐Markiewicz, Iwona Ziolkowska‐Suchanek, Agnieszka Zimna, Tomasz Oldak, Natalia Rozwadowska, Anna Sarnowska   +12 more
wiley   +1 more source

Nomogram prediction model for prognosis of patients with amyotrophic lateral sclerosis. [PDF]

BMC Neurol
Sun Q, Wang H, Deng G, Du Y, Ma T, Ding J, Xia Z, Jiang Y, Huang Y, Huang X.   +9 more
europepmc   +1 more source

Between Safeguard and Constraint: Navigating Patient Autonomy in Protective Laws for Medical Assistance in Dying

Bioethics, EarlyView.
ABSTRACT There has been an increase in the number of jurisdictions legalizing or decriminalizing Medical Assistance in Dying (MAiD). Legal frameworks worldwide strive to balance respect for autonomy with regulatory safeguards that both operationalize voluntary choice and prevent access to MAiD in cases of remediable despair or coerced decision‐making ...
Janet Delgado, Iris Parra Jounou, Mar Vallès‐Poch, Ramón Ortega‐Lozano, María Victoria Martínez‐López, Luis Espericueta, Maria Isabel Tamayo‐Velázquez, David Rodríguez‐Arias, Rosana Triviño‐Caballero   +8 more
wiley   +1 more source