Results 161 to 170 of about 167,403 (289)

An Open‐Label Phase 1b Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of ANX005 in Patients with Huntington's Disease

Movement Disorders, EarlyView.
Complement activation is implicated in Huntington's disease; ANX005 is a potent inhibitor of component C1q. ANX005 exhibited a generally manageable safety profile with rapid reduction in C1q in the cerebrospinal fluid. Functional ability on composite Unified Huntington's Disease Rating Scale and total functional capacity was maintained, with potential ...
Rajeev Kumar, Pinky Agarwal, Karen Anderson, Daniel Claassen, Marissa Dean, Andrew Duker, Burton Scott, Benjamin Hoehn, Ann Mongan, Ping Lin, Ellen Cahir‐McFarland, Lori Taylor, Glenn Morrison, Ted Yednock, Sanjay Keswani, Henk‐Andre Kroon   +15 more
wiley   +1 more source

Author Correction: Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis. [PDF]

Nature
Michaelis T, Lindestam Arlehamn CS, Johansson E, Frazier A, Williams GP, Berry JD, Cudkowicz M, Goyal NA, Fournier C, Snyder A, Kwan JY, Crook J, Phillips EJ, Mallal SA, Ravits J, Marder KS, Sidney J, Sulzer D, Sette A.   +18 more
europepmc   +1 more source

Natural Killer Subset Changes and Vascular Endothelial Growth Factor‐A Plasma Profile in Progressive Supranuclear Palsy: The NKscape Study

Movement Disorders, EarlyView.
Abstract Background Emerging evidence implicates neuroinflammation in progressive supranuclear palsy (PSP) pathophysiology, with elevated cyto‐chemokines suggesting natural killer (NK) cell involvement. Methods We characterized peripheral NK in PSP (N = 11) versus Parkinson's disease (PD, N = 10) and healthy controls (HC, N = 8) at both ...
Marina Picillo, Cristina Basile, Francesco Montella, Valentina Lopardo, Mariangela Orlando, Roberta Tarallo, Domenico Palumbo, Viola Melone, Maria Francesca Tepedino, Paolo Barone, Annibale Alessandro Puca, Elena Ciaglia   +11 more
wiley   +1 more source

Long-Term Tofersen in SOD1 Amyotrophic Lateral Sclerosis. [PDF]

JAMA Neurol
Miller TM, Cudkowicz ME, Shaw PJ, Genge A, Sobue G, Bucelli RC, Chiò A, Van Damme P, Ludolph AC, Glass JD, Andrews JA, Babu S, Benatar M, McDermott CJ, Salachas F, Bruneteau G, Al-Chalabi A, Amorin M, Nestorov I, Graham D, Lin L, Sun P, McNeill M, Malek S, Inra J, Garafalo S, Fradette S, VALOR and OLE Working Group.   +27 more
europepmc   +1 more source

A Case-Study Survey of an Eight-year Cluster of Motor Neurone Disease (MND) Referrals in a Rural English Village: Exploring Possible Aetiological Influences in a Hypothesis Stimulating Study [PDF]

, 2014
Pritchard, Colin, Silk, A.
core   +1 more source

The Expanding Landscape of Microbiota Medicine: Indications, Therapeutic Modalities, and the Path Towards Integrative Microbiome‐Targeting Healthcare

Microbiota Medicine Research, EarlyView.
ABSTRACT The growing recognition of the microbiome's role in human health has propelled the emergence of microbiota medicine—a new discipline integrating microbiology, multi‐omics, and clinical science. Advances in sequencing, data integration, and interventions such as fecal microbiota transplantation (FMT) have transitioned the field from ...
Min Dai, Yisha Lin, Renyou Gan, Xiaotao Shen, Shin Young Park, Sunjae Lee, Qi Su   +6 more
wiley   +1 more source

Correction: Multidimensional predictors of fatigue in amyotrophic lateral sclerosis: a cross-sectional study in China. [PDF]

Sci Rep
Cai F, Xu D, Yang D, Huang F, Song X, Jiang Q, Wan S, Zhao Y, Zhou J.   +8 more
europepmc   +1 more source

Enhanced Quantitative Phosphocreatine MR Imaging of Skeletal Muscle Using a Global–Local Two‐Branch Deep Learning Model

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Phosphocreatine (PCr) is an essential marker of muscle metabolism, and accurate quantification of its (fs) and its exchange rate (ksw) is essential for diagnosing various muscular and neuromuscular diseases. Although chemical exchange saturation transfer (CEST) MRI can detect the saturation transfer effect from PCr, quantification of ...
Malvika Viswanathan, Leqi Yin, Yashwant Kurmi, Shuyang Chai, Xiaoyu Jiang, Yuankai Huo, Junzhong Xu, Limin Chen, John C. Gore, Zhongliang Zu   +9 more
wiley   +1 more source

New Hopes and Challenges for Treatment of Neurodegenerative Disorders: Great Opportunities for Young Neuroscientists

Basic and Clinical Neuroscience, 2013
Mahmoud Kiaei
doaj  

The Amyotrophic Lateral Sclerosis House Call Program: A Single-Center Experience in the United States. [PDF]

Neurol Res Int
Scirocco E, Scalia J, Ugolini B, Casagrande G, Ho D, Hagar JL, Kingsley K, Hoffman R, Cooley C, Cudkowicz ME, Paganoni S, Berry JD.   +11 more
europepmc   +1 more source