Results 161 to 170 of about 995,258 (307)

Neuropsychological Sub-Phenotypes in Amyotrophic Lateral Sclerosis. [PDF]

Eur J Neurol
Poletti B, Aiello EN, Consonni M, Iazzolino B, Torre S, Faltracco V, Telesca A, Palumbo F, Curti B, De Luca G, Moreschi A, Frisco F, Bella ED, Bersano E, Riva N, Verde F, Messina S, Doretti A, Maranzano A, Morelli C, Cappa SF, Calvo A, Strong MJ, Silani V, Lauria G, Chiò A, Ticozzi N.   +26 more
europepmc   +1 more source

SPG4 Hereditary Spastic Paraplegia: From Etiology to Therapy

Movement Disorders, EarlyView.
Abstract Hereditary spastic paraplegias (HSPs) comprise a heterogeneous group of heritable neurodegenerative disorders resulting from mutations in a wide variety of genes. HSP locomotor symptoms include lower limb weakness and spasticity that arise from progressive degeneration of corticospinal axons projecting from the motor cortex to the distal ...
Emanuela Piermarini, Peter W. Baas
wiley   +1 more source

Repairing the Amyotrophic Lateral Sclerosis Trial Credibility Gap. [PDF]

Neurology
Benatar M, Rothstein JD, Snow K, Sethi N, Taylor DM, Dave KD, McDermott CJ, Cochrane TI.   +7 more
europepmc   +1 more source

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay, Lynn C. Lunsonga, Peter E. Light, Khaled Barakat   +3 more
wiley   +1 more source

Falls in people with amyotrophic lateral sclerosis: A prospective study. [PDF]

Braz J Phys Ther
Alencar MA, Gonçalves JMW, D Allembert D, Rangel MFA, Gomes PCF, de Souza LC.   +5 more
europepmc   +1 more source

Deficient Repair of Alkylation Damage of DNA in Alzheimer’s Disease and Amyotrophic Lateral Sclerosis Cells

The etiology of amyotrophic lateral sclerosis (ALS) is still unknown. There are many pieces of evidence linking ALS, Alzheimer’s disease and Parkinson’s disease.
Bradley, W. G, Robison, S. H, Tandan, R   +2 more
core   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

The Role of Neurofilaments in Diagnosis and Monitoring of Amyotrophic Lateral Sclerosis. [PDF]

J Clin Med
Davies A, Bentley A, Bikov A.
europepmc   +1 more source

Washed Microbiota Transplantation Improves Chronic‐Phase Febrile Infection‐Related Epilepsy Syndrome: The First Case Report With Long‐Term Follow‐Up and Integrated Multi‐Omics Analysis

Microbiota Medicine Research, EarlyView.
ABSTRACT Background Febrile infection‐related epilepsy syndrome (FIRES) is a catastrophic epileptic encephalopathy. Survivors often enter a chronic phase characterized by drug‐resistant epilepsy, cognitive impairment, behavioral and psychiatric symptoms, and long‐term functional disability.
Qianqian Li, Xiao Ding, Sheng Zhang, Faming Zhang   +3 more
wiley   +1 more source

AGRN‐, LRP4‐, MUSK‐Related CMS: Clinical, Neurophysiological, Morphological, Genetic and Pathological Mechanisms

Muscle &Nerve, EarlyView.
ABSTRACT Congenital myasthenic syndromes (CMS) are inherited disorders caused by mutations in genes encoding proteins essential for neuromuscular junction (NMJ) function. Pathogenic variants have been identified in more than 35 genes, underscoring the complexity of synaptic biology and the wide range of mechanisms that can compromise neuromuscular ...
Rocio‐Nur Villar‐Quiles, Damien Sternberg, Marie‐Christine Nougues, Arnaud Isapof, Bruno Eymard, Stéphanie Bauché   +5 more
wiley   +1 more source