Results 141 to 150 of about 995,258 (307)

Pharmacotherapy of Amyotrophic Lateral Sclerosis

, 2018
Amyotrophic lateral sclerosis (ALS or motor neuron disease) is a progressive neurodegenerative disease associated with loss of upper and lower motor neurons. The diagnosis of ALS is still made at the clinic or bedside by an experienced neurologist.
Al habis, Mohammed Hamad S
core  

Environmental and occupational risk factors of amyotrophic lateral sclerosis: a population-based case control study [PDF]

, 2016
Background and aims Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of the motor neuron. Its etiology is still largely unknown, except for some rare forms of genetic origin, but environmental factors may have an ...
Mauceri, Cristina, Ferrante, Margherita, Fini, Nicola, Fiore, Maria, VINCETI, Marco, Violi, Federica, MANDRIOLI, Jessica, Patti, Francesco, FILIPPINI, TOMMASO, Ledda, Caterina, Dimartino, Angela, MALAGOLI, Carlotta   +11 more
core  

Increased prevalence of bladder and intestinal dysfunction in amyotrophic lateral sclerosis.

, 2014
Amyotrophic lateral sclerosis (ALS) is predominantly characterized by a progressive loss of motor function. While autonomic dysfunction has been described in ALS, little is known about the prevalence of lower urinary tract symptoms (LUTS) and intestinal ...
Nübling, G.S., Irwin, D.E., Hapfelmeier, A., Mie, E., Lorenzl, S., Winkler, A.S., Hensler, M., Borasio, G.D., Bauer, R.M.   +8 more
core   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Neurolathyrism in Sub‐Saharan Africa—Assessing the Neurotoxic Risks of Lathyrus sativus Amid Drought and Food Security Challenges

Food Safety and Health, EarlyView.
Representation of grass pea consumption in drought‐stricken sub‐Saharan Africa sustains nutrition, but excess β‐ODAP exposure due to multiple reasons triggers neurolathyrism, a progressive neurotoxic disorder. ABSTRACT Neurolathyrism is a progressive motor neuron disease due to the consumption of Lathyrus sativus (grass pea) over long periods.
Biruk Demisse Ayalew, Muhammad Umar, Pakeezah Tabasum, Maria Qadri, Talha Farooq, Eskeatnaf Yosef Getachew, Zemichael Getu Alemayehu, Eden Haile Hagos, Hailemariam Shimelis Gebeyehu, Hanna Tsehay Abebe, Nuradin Abdi Ali, David Chinaecherem Innocent, Temesgen Mamo Sharew   +12 more
wiley   +1 more source

Cardiac troponin T as a serum biomarker of respiratory impairment in amyotrophic lateral sclerosis

Annals of Clinical and Translational Neurology
Objective Informative biomarkers are an urgent need in the management of amyotrophic lateral sclerosis. Serum cardiac troponin T is elevated in the majority of amyotrophic lateral sclerosis patients and increases with disease progression.
Teresa Koch, Rachel Fabian, Leonie Weinhold, Franz‐W. Koch, Saman Barakat, Sergio Castro‐Gomez, Torsten Grehl, Sarah Bernsen, Patrick Weydt   +8 more
doaj   +1 more source

Dissecting the Molecular Mechanisms of Motor Neurone Disease in Yeast and Worms [PDF]

Superoxide dismutase 1 (SOD1) is an enzyme responsible for intracellular breakdown of toxic reactive oxygen species in prokaryotes and eukaryotes. Mutations in SOD1 are linked to the motor neurone disease Amyotrophic lateral sclerosis (ALS), with around ...
Peswani, Amber Rose
core  

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Survival of individuals with neurological and oncological diseases receiving home enteral nutrition: A descriptive cohort study

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Introduction Home enteral nutrition is mainly indicated for individuals with neurological or oncological diseases. However, few studies have evaluated survival in this population in low‐ and middle‐income countries. Objective To investigate factors influencing survival in individuals receiving home enteral nutrition and to identify variables ...
Giuliane de Matos Wrobel, Cesar Augusto Taconeli, Rubia Daniela Thieme, Maria Eliana Madalozzo Schieferdecker   +3 more
wiley   +1 more source