Results 271 to 280 of about 242,580 (385)

Frontotemporal dementia: Clinical aspects, genetics, and neuropathology of a family with a C9ORF72 expansion in Argentina

Brain Pathology, EarlyView.
Immunohistochemistry for TDP‐43: (A)—Dentate gyrus; (B)—Temporal lobe. Abstract Frontotemporal dementia (FTD) is the second most common cause of early‐onset dementia, typically manifesting before the age of 65, with a mean onset at 58 years. FTD may encompass a spectrum of neurodegenerative disorders resulting from frontotemporal lobar degeneration ...
Karen Daniela Román, Carolina Agata Ardohain, Ezequiel I. Surace, Mónica Beatriz Mezmezian, Alejandro Levy, Alice Baez Lovera, Carlos Turizo, Marcos G. Sorbara, María M. Esnaola y Rojas, Gastón H. Graviotto, Gustavo Sevlever, Ricardo F. Allegri, Cecilia M. Serrano, Nahuel Magrath Guimet   +13 more
wiley   +1 more source

Dissecting epigenetic age acceleration in amyotrophic lateral sclerosis. [PDF]

Epigenomics
Merbaum P, Zwamborn R, Hop P, Sequencing Consortium PMA, van Rheenen W, Veldink J.   +5 more
europepmc   +1 more source

Cognitive correlates in amyotrophic lateral sclerosis: a population-based study in Italy

, 2014
Anna Montuschi, Barbara Iazzolino, Andrea Calvo, Cristina Moglia, Leonardo Lopiano, Gabriella Restagno, Maura Brunetti, Irene Ossola, Anna Lo Presti, Stefania Cammarosano, Antonio Canosa, Adriano Chiò   +11 more
openalex   +2 more sources

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Gene Therapy for Amyotrophic Lateral Sclerosis (ALS) Using a Polymer Encapsulated Xenogenic Cell Line Engineered to Secrete hCNTF. Lausanne University Medical School, Lausanne, Switzerland

, 1996
Nicole Anne-Marie Pochon, Bruno Heyd, Nicole Déglon, Jean‐Marc Joseph, Anne D. Zurn, E. Edward Baetge, Joseph P. Hammang, Moses Goddard, Michael J. Lysaght, F. Kaplan, Amami Kato, Myriam Schluep, Lorenz Hirt, F Régli, François Porchet, N. de Tribolet, Patrick Aebischer   +16 more
openalex   +2 more sources

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Macroglossia Caused by Venous Congestion in a Patient With Amyotrophic Lateral Sclerosis. [PDF]

Clin Case Rep
Hino S, Iijima Y, Nakayama N, Horie N, Kaneko T.   +4 more
europepmc   +1 more source

Protective effects of Withania somnifera extract in SOD1G93A mouse model of amyotrophic lateral sclerosis

, 2018
Kallol Dutta, Priyanka Patel, Jean‐Pierre Julien   +2 more
openalex   +1 more source

In‐Tumor CRISPR‐Cas9 Knockout Screening and Novel Therapy Development for Malignant Transformation of Ovarian Teratoma

Cancer Science, EarlyView.
We conducted an in vivo genome‐wide CRISPR‐Cas9 knockout screen using MTMCT‐derived cells to identify genes essential for tumor growth. SOD1 emerged as a key therapeutic target, and its inhibition suppressed tumor proliferation by disrupting redox homeostasis, both in vitro and in PDX models. ABSTRACT Malignant transformation of mature cystic teratoma (
Satoshi Tamauchi, Kosuke Yoshida, Wang Xinyuan, Atsushi Nakagawa, Akira Yokoi, Nobuhisa Yoshikawa, Kaoru Niimi, Yusuke Yamamoto, Hiroaki Kajiyama   +8 more
wiley   +1 more source

Identification of Comprehensive Landscape of Peripheral Immunity and Chemokine-Related Genes in Amyotrophic Lateral Sclerosis. [PDF]

Immunotargets Ther
Yang X, Huang S, Wang Y, Yuan J, Yao X.
europepmc   +1 more source