Results 41 to 50 of about 148,501 (250)

Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis

Frontiers in Molecular Neuroscience, 2019
TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as inclusion bodies in the brain and spinal cord of patients with the motor neuron ...
A. Prasad, Vidhya Bharathi, V. Sivalingam, A. Girdhar, B. Patel   +4 more
semanticscholar   +1 more source

Real-world evidence of riluzole effectiveness in treating amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2020
Objective To compare the effect of riluzole on median survival in population studies of patients with amyotrophic lateral sclerosis (ALS) with that observed in clinical trials.
Jinsy A. Andrews, C. Jackson, T. Heiman-Patterson, P. Bettica, B. Brooks, E. Pioro   +5 more
semanticscholar   +1 more source

Longitudinal biomarkers in amyotrophic lateral sclerosis

Annals of Clinical and Translational Neurology, 2020
To investigate neurodegenerative and inflammatory biomarkers in people with amyotrophic lateral sclerosis (PALS), evaluate their predictive value for ALS progression rates, and assess their utility as pharmacodynamic biomarkers for monitoring treatment ...
F. Huang, Yuda Zhu, Jennifer Hsiao‐Nakamoto, Xinyan Tang, J. Dugas, M. Moscovitch-Lopatin, J. Glass, Robert H. Brown, S. Ladha, D. Lacomis, Jeffrey M Harris, K. Scearce-Levie, Carole Ho, R. Bowser, J. Berry   +14 more
semanticscholar   +1 more source

TDP-43 real-time quaking induced conversion reaction optimization and detection of seeding activity in CSF of amyotrophic lateral sclerosis and frontotemporal dementia patients

Brain Communications, 2020
The pathological deposition of the transactive response DNA-binding protein of 43 kDa occurs in the majority (∼97%) of amyotrophic lateral sclerosis and in around 45% of frontotemporal lobar degeneration cases.
C. Scialò, Thanh Hoa Tran, Giulia Salzano, G. Novi, C. Caponnetto, A. Chiò, A. Calvo, A. Canosa, F. Moda, P. Caroppo, V. Silani, N. Ticozzi, A. Ratti, B. Borroni, L. Benussi, R. Ghidoni, G. Furlanis, P. Manganotti, B. Senigagliesi, P. Parisse, R. Brasselet, E. Buratti, G. Legname   +22 more
semanticscholar   +1 more source

Epidemiology of amyotrophic lateral sclerosis: an update of recent literature

Current Opinion in Neurology, 2019
Purpose of review The cause of amyotrophic lateral sclerosis (ALS) remains unknown for most of the patients with the disease. Epidemiologic studies can help describe disease burden and examine its potential risk factors, providing thereby evidence base ...
Elisa Longinetti, F. Fang
semanticscholar   +1 more source

OSMR is a potential driver of inflammation in amyotrophic lateral sclerosis

Neural Regeneration Research
Amyotrophic lateral sclerosis is a neurodegenerative disease, and the molecular mechanism underlying its pathology remains poorly understood. However, inflammation is known to play an important role in the development of this condition.
Wenzhi Chen, Shishi Jiang, Shu Li, Cheng Li, Renshi Xu   +4 more
doaj   +1 more source

Cerebellar pathology in motor neuron disease: neuroplasticity and neurodegeneration

Neural Regeneration Research, 2022
Amyotrophic lateral sclerosis is a relentlessly progressive multi-system condition. The clinical picture is dominated by upper and lower motor neuron degeneration, but extra-motor pathology is increasingly recognized, including cerebellar pathology. Post-
Rangariroyashe H Chipika, Grainne Mulkerrin, Pierre-François Pradat, Aizuri Murad, Fabrice Ango, Cédric Raoul, Peter Bede   +6 more
doaj   +1 more source

ASSOCIATION OF SPORADIC AMYOTROPHIC LATERAL SCLEROSIS WITH HUMAN T LYMPHO-TROPIC VIRUS 1, HUMAN IMMUNODEFICIENCY VIRUS AND HUMAN HERPES VIRUS 8 [PDF]

Acta Medica Iranica, 2006
Amyotrophic lateral sclerosis is a progressive neurodegenerative disease with uncertain etiology. For many years, viruses have been suspected as causative agents. There are conflicting reports about the possible role of viruses such as human herpes virus
A. Tarazi, S. Nafissi, A. A. Amirzargar, P. Ayatollahi A. Soltanzadeh   +3 more
doaj   +2 more sources

Pain in amyotrophic lateral sclerosis [PDF]

The Lancet Neurology, 2017
Pain is a largely neglected symptom in patients with amyotrophic lateral sclerosis (ALS) although it is reported by most of these patients. It occurs at all stages of the disease and can be an onset symptom preceding motor dysfunction. Pain is correlated with a deterioration in patients' quality of life and increased prevalence of depression.
CHIO', Adriano, Mora, Gabriele, LAURIA, GIUSEPPE   +2 more
openaire   +2 more sources

Resilience, anxiety, and depression in amyotrophic lateral sclerosis patients

Psychiatria i Psychologia Kliniczna, 2019
Introduction: Research into amyotrophic lateral sclerosis often focuses on the purely medical aspects of the disease, without paying attention to patient’s experience, suffering and difficulties they face on a daily basis.
Alessia Demuru, Claudio Longobardi, Laura Elvira Prino, Michele Settanni   +3 more
doaj   +1 more source