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Psychological Characteristics of Patients with Amyotrophic Lateral Sclerosis (ALS)
Psychosomatic Medicine, 1977Previous research has suggested that patients with amyotrophic lateral sclerosis (ALS) demonstrate similar psychological characteristics that distinguish them from the medically ill populations, and that these findings may bear etiologic and prognostic importance.
J L, Houpt, B S, Gould, F H, Norris
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Molecular Abnormalities in Sporadic Amyotrophic Lateral Sclerosis (ALS)
The FASEB Journal, 2007ALS is a neurodegenerative disease affecting both upper and lower motor neurons. A mutation in the superoxide dismutase I (SOD1) gene has been implicated in the familial form of disease; however, little is known about the pathogenesis of sporadic ALS, which accounts for 90–95% of the cases.
Hannah Perrin +4 more
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Stem cells in the treatment of amyotrophic lateral sclerosis (ALS)
Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 2002Until fairly recently, interest in stem cells was restricted to neurobiology studies on the principles of embryonic development. This situation has changed rapidly in the last few years when neuronal stems and precursors were isolated in vitro, thus allowing expansion and controlled differentiation of selective populations of neuronal cells.
V. Silani +5 more
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Immunological Assessment in Sporadic Amyotrophic Lateral Sclerosis (ALS)
1987The immune system may be able to contribute to the pathogenesis of ALS as it has to other neurological diseases such as experimental allergic encephalomyelitis, multiple sclerosis and lymphocytic choriomeningitis. The selective damage to upper and lower motor neurons in ALS might be regarded as a feature of a brain-confined, organ-specific autoimmune ...
L, Provinciali +4 more
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Pridopidine in Amyotrophic Lateral Sclerosis
JAMAImportanceAmyotrophic lateral sclerosis (ALS) is a fatal disease. The sigma-1 (σ1) receptor emerged as a target for intervention.ObjectiveTo determine the effects of pridopidine, a σ1-receptor agonist, in ALS.Design, Settings, and ParticipantsPridopidine was tested as a regimen of the HEALEY ALS Platform Trial, a phase 2/3, multicenter, randomized ...
Douglas Hayden +205 more
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Overview of Lipid Biomarkers in Amyotrophic Lateral Sclerosis (ALS)
2019Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative disease involving motor neuron (MN) degeneration in the spinal cord, brain stem and primary motor cortex. The existence of inflammatory processes around MN and axonal degeneration in ALS has been shown.
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Prevalence of amyotrophic lateral sclerosis (ALS), United States, 2016
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2022Paul Mehta +2 more
exaly