The role of autophagy in the pathogenesis and treatment of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). [PDF]
Autophagy RepBeckers J, Van Damme P.
europepmc +1 more source
Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System
Annals of Neurology, Volume 100, Issue 4, Page 709-736, October 2026.Objective Tau is widely studied in neurodegeneration, yet most work has focused on canonical brain tau isoforms. A longer isoform, “big tau,” produced by inclusion of exon 4a, is expressed in the peripheral nervous system (PNS) and central nervous system (CNS) regions.
Rama Krishna Koppisetti +17 more
wiley +1 more source
Editorial: Innovative approaches to catalyze preclinical and clinical research on amyotrophic lateral sclerosis (ALS) and related disorders. [PDF]
Front NeurosciBurg T, Tzeplaeff L, Cassel R, Lingor P.
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Glymphatic System Dysfunction and its Associated Factors in Wilson's Disease: A DTI–ALPS Study
Brain and Behavior, Volume 16, Issue 10, October 2026.Glymphatic function, assessed by DTI‐ALPS index, was impaired in neurological Wilson's disease compared with hepatic phenotype and controls. Age, AST, and UWDRS‐I score independently predicted dysfunction, linking neurodegeneration, liver injury, and altered glymphatic activity. ABSTRACT Background Wilson's disease (WD) is a genetic disorder of copper (
Ling Zhu +14 more
wiley +1 more source
A Novel Retinal Nerve Fiber Layer Biomarker of Amyotrophic Lateral Sclerosis (ALS) Identified Using Longitudinal in vivo Ocular Imaging. [PDF]
Eye BrainKhorrami F +4 more
europepmc +1 more source
On the importance of including both sexes in animal studies – insights from home‐cage monitoring
Biological Reviews, Volume 101, Issue 5, Page 2408-2426, October 2026.ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater +12 more
wiley +1 more source
Use of Proteomics to Explore Biomarkers of Amyotrophic Lateral Sclerosis (ALS): Proof of Principle from Humanized SOD1 Mouse to Human ALS. [PDF]
ACS Pharmacol Transl SciSanghai N, Tranmer GK.
europepmc +1 more source
Clinical Case Reports, Volume 14, Issue 10, October 2026.Schematic summary of the perioperative management and clinical course of emergency laparotomy in a patient with advanced motor neurone disease (MND). ABSTRACT Motor neurone disease (MND) presents significant perioperative challenges due to progressive respiratory muscle weakness, bulbar dysfunction, autonomic instability, and altered sensitivity to ...
Sherif Elmahgoub +2 more
wiley +1 more source
Screening of visuospatial abilities in amyotrophic lateral sclerosis (ALS): a pilot study using the battery for visuospatial abilities (BVA). [PDF]
Orphanet J Rare DisSharbafshaaer M +9 more
europepmc +1 more source
Impaired Motor Function in a Zebrafish Stathmin‐2 Knockout Model
Developmental Neurobiology, Volume 86, Issue 4, October 2026.ABSTRACT Stathmin‐2 (STMN2) is a microtubule‐associated protein that plays a role in the stability of microtubules in axons of the nervous system of animals. In this study, we generated a novel zebrafish STMN2 knockout (KO) model. STMN2 is represented by two genes in the zebrafish genome: stmn2a and stmn2b.
Tyler J. N. Gurberg +6 more
wiley +1 more source