Results 201 to 210 of about 2,700,197 (262)

Palliative care pathways in Amyotrophic Lateral Sclerosis (ALS): a sequence analysis of health claims data. [PDF]

BMC Palliat Care
Schmidt R, Slotina E, Meissner F, Metelmann M, Ilse B, Vogt V, Freytag A.   +6 more
europepmc   +1 more source

From mouth to brain: Linking periodontal and peri‐implant dysbiosis to systemic inflammation and neuropathology

Periodontology 2000, EarlyView.
Abstract Background/Aim Growing evidence suggests that imbalances occurring within the human microbiota and deregulation of the host immune response may play a significant role in the development of neurodegenerative diseases. Materials and Methods A comprehensive narrative review of the latest experimental, clinical, and epidemiological insights was ...
Emilio A. Cafferata, Frank Schwarz, Jaime Díaz‐Zúñiga, Alpdogan Kantarci   +3 more
wiley   +1 more source

Mutant TDP-43 drives impairments in axonal transport and glycolysis in a mouse stem-cell-derived motor neuron model of amyotrophic lateral sclerosis (ALS). [PDF]

Cell Death Dis
Carroll E, Scaber J, Pasniceanu IS, Dafinca R, Gordon D, Candalija A, Talbot K.   +6 more
europepmc   +1 more source

Uncovering the impact of the cardiovascular system on cerebrovascular health using MRI

Experimental Physiology, EarlyView.
Abstract Human cerebrovasculature is finely tuned to enable local changes in blood flow to meet the brain's demands, whilst protecting the brain from systemic changes in blood pressure, both acutely during a heartbeat and chronically over time. This review summarises cerebrovascular structure and function, their role in disease and neurodegeneration ...
Ian D. Driver, Kevin Murphy
wiley   +1 more source

White adipose tissue undergoes pathological dysfunction in the TDP-43^A315T mouse model of amyotrophic lateral sclerosis (ALS). [PDF]

Acta Neuropathol Commun
Benito-Casado C, Durán-Mateos E, Ferrer-Donato Á, García GB, Domínguez-Rubio R, Povedano M, Fernandez-Martos CM.   +6 more
europepmc   +1 more source

Ageing alters cysteine oxidation‐regulated redox signalling in skeletal muscle: Integrative omics and AI‐based structural predictions

Experimental Physiology, EarlyView.
Abstract Ageing is associated with loss of skeletal muscle mass and strength (sarcopenia) and disrupted redox homeostasis. Redox signalling is essential for muscle adaptation, yet the mechanisms by which ageing disrupts cysteine‐based regulation are poorly defined. The drivers of site‐specific reactivity and signalling specificity in aged muscle remain
Ufuk Ersoy, Malcolm J. Jackson
wiley   +1 more source

Amyotrophic Lateral Sclerosis (ALS) Type 8: A Narrative Review. [PDF]

Cureus
McBenedict B, Hauwanga WN, Nezam U, Ko Oo A, Eapi S, Pradhan S, Dang NB, Cher PW, Orsini MA, Lima Pessôa B.   +9 more
europepmc   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Strengths and Opportunities: Clinicians' Perspectives on Palliative Care for Amyotrophic Lateral Sclerosis (ALS) in the United States. [PDF]

Muscle Nerve
Bischoff KE, Kojimoto G, O'Riordan DL, Leavell YL, Maiser S, Grouls A, Smith AK, Pantilat SZ, Kluger BM, Mehta AK.   +9 more
europepmc   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source