Results 181 to 190 of about 95,709 (300)

An Open‐Label Phase 1b Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of ANX005 in Patients with Huntington's Disease

Movement Disorders, EarlyView.
Complement activation is implicated in Huntington's disease; ANX005 is a potent inhibitor of component C1q. ANX005 exhibited a generally manageable safety profile with rapid reduction in C1q in the cerebrospinal fluid. Functional ability on composite Unified Huntington's Disease Rating Scale and total functional capacity was maintained, with potential ...
Rajeev Kumar, Pinky Agarwal, Karen Anderson, Daniel Claassen, Marissa Dean, Andrew Duker, Burton Scott, Benjamin Hoehn, Ann Mongan, Ping Lin, Ellen Cahir‐McFarland, Lori Taylor, Glenn Morrison, Ted Yednock, Sanjay Keswani, Henk‐Andre Kroon   +15 more
wiley   +1 more source

Greek Registry for Amyotrophic Lateral Sclerosis (ALS-GR): An Observational Cohort of Individuals With ALS Across 11 Specialized Centers in Greece. [PDF]

Eur J Neurol
Liampas I, Kimiskidis VK, Zouvelou V, Veltsista D, Moscholouri A, Triantafyllou E, Daponte A, Xirou S, Sterpi AE, Salakou S, Poulidou V, Arnaoutoglou M, Tsouris Z, Ralli S, Dardiotis E, Papagiannopoulos S, Zampetakis A, Zaganas Ι, Mitsias P, Giannakis A, Konitsiotis S, Kefalas F, Alexiou E, Stoiloudis P, Parissis D, Kiamelidis S, Terzoudi A, Tsivgoulis G, Rentzos M, Chroni E.   +29 more
europepmc   +1 more source

Natural Killer Subset Changes and Vascular Endothelial Growth Factor‐A Plasma Profile in Progressive Supranuclear Palsy: The NKscape Study

Movement Disorders, EarlyView.
Abstract Background Emerging evidence implicates neuroinflammation in progressive supranuclear palsy (PSP) pathophysiology, with elevated cyto‐chemokines suggesting natural killer (NK) cell involvement. Methods We characterized peripheral NK in PSP (N = 11) versus Parkinson's disease (PD, N = 10) and healthy controls (HC, N = 8) at both ...
Marina Picillo, Cristina Basile, Francesco Montella, Valentina Lopardo, Mariangela Orlando, Roberta Tarallo, Domenico Palumbo, Viola Melone, Maria Francesca Tepedino, Paolo Barone, Annibale Alessandro Puca, Elena Ciaglia   +11 more
wiley   +1 more source

To Treat or Not to Treat: A Scoping Review of Speech Treatment for Dysarthria in Amyotrophic Lateral Sclerosis (ALS). [PDF]

Healthcare (Basel)
Whelan BM, Aldridge D, Ruhle J, Whitelock P, Taubert S, Collins A, Kearney E, Charania S, Henderson RD, Wallace SJ, Mitchell C, Stipancic KL, Kuruvilla-Dugdale M, Vogel AP.   +13 more
europepmc   +1 more source

From Amyotrophic Lateral Sclerosis to Neurodegenerative Diseases: A Scoping Review of Artificial Intelligence‐Powered Chatbots for Addressing Patients' and Caregivers' Information Needs

Medicine Advances, EarlyView.
This scoping review synthesizes evidence from 24 studies (2019–2024) to examine how AI‐powered chatbots address patients' and caregivers' health information needs across diseases. Findings highlight key benefits such as accessibility, empowerment, efficiency, and personalization, alongside important limitations related to empathy, language and ...
Julie Desgroseilliers, Christine Hamel, Kathy Ogundokun, Karine Latulippe   +3 more
wiley   +1 more source

Advances in Understanding and Treating Amyotrophic Lateral Sclerosis (ALS): A Comprehensive Review. [PDF]

Cureus, 2023
Gupta D, Vagha S, Dhingra H, Shirsath H.
europepmc   +1 more source

The Expanding Landscape of Microbiota Medicine: Indications, Therapeutic Modalities, and the Path Towards Integrative Microbiome‐Targeting Healthcare

Microbiota Medicine Research, EarlyView.
ABSTRACT The growing recognition of the microbiome's role in human health has propelled the emergence of microbiota medicine—a new discipline integrating microbiology, multi‐omics, and clinical science. Advances in sequencing, data integration, and interventions such as fecal microbiota transplantation (FMT) have transitioned the field from ...
Min Dai, Yisha Lin, Renyou Gan, Xiaotao Shen, Shin Young Park, Sunjae Lee, Qi Su   +6 more
wiley   +1 more source

Nanjing Consensus II on Washed Microbiota Transplantation: Statements From the CHINAGUT Conference

Microbiota Medicine Research, EarlyView.
ABSTRACT The new method of fecal microbiota transplantation, based on automatic facilities and washing processes, was coined as washed microbiota transplantation (WMT). The first recommendations on WMT were released as Nanjing Consensus report by the fecal microbiota transplantation (FMT)‐standardization Study Group in 2019.
Faming Zhang, Sunny Hei Wong, Gaochen Lu, Zheshun Pi, Ting Zhang, Hon Ho Yu, Nan Bu, Xiong Chen, Bota Cui, Dafa Ding, Hainv Gao, Suyu He, Xingxiang He, Shengjuan Hu, Jia Hu, Yunlian Hu, Xiaomeng Jiang, Jiang Jin, Jingnan Li, Pan Li, Juan Liao, Weiwei Liao, Jiang Liu, Ling Liu, Yaping Liu, Yanyan Liu, Yu Liu, Muhan Lv, Xiangjun Meng, Yongzhan Nie, Qian Ren, Lixuan Sang, Yang Sun, Xiaowen Tang, Liangjing Wang, Wei Wang, Xin Wang, Yanling Wei, Quan Wen, Lihao Wu, Xia Wu, Fang Xiao, Lijing Xiong, Shaoqi Yang, Song Yang, Guoliang Ye, Yue Zeng, Huihong Zhai, Xiaoqian Zhang, Yu Zhang, Kun Zhao, Li Zhou, Li Zhu, Kaichun Wu   +53 more
wiley   +1 more source

Mutant TDP-43 drives impairments in axonal transport and glycolysis in a mouse stem-cell-derived motor neuron model of amyotrophic lateral sclerosis (ALS). [PDF]

Cell Death Dis
Carroll E, Scaber J, Pasniceanu IS, Dafinca R, Gordon D, Candalija A, Talbot K.   +6 more
europepmc   +1 more source

Enhanced Quantitative Phosphocreatine MR Imaging of Skeletal Muscle Using a Global–Local Two‐Branch Deep Learning Model

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Phosphocreatine (PCr) is an essential marker of muscle metabolism, and accurate quantification of its (fs) and its exchange rate (ksw) is essential for diagnosing various muscular and neuromuscular diseases. Although chemical exchange saturation transfer (CEST) MRI can detect the saturation transfer effect from PCr, quantification of ...
Malvika Viswanathan, Leqi Yin, Yashwant Kurmi, Shuyang Chai, Xiaoyu Jiang, Yuankai Huo, Junzhong Xu, Limin Chen, John C. Gore, Zhongliang Zu   +9 more
wiley   +1 more source