Results 161 to 170 of about 49,177 (260)

Strengths and Opportunities: Clinicians' Perspectives on Palliative Care for Amyotrophic Lateral Sclerosis (ALS) in the United States. [PDF]

Muscle Nerve
Bischoff KE, Kojimoto G, O'Riordan DL, Leavell YL, Maiser S, Grouls A, Smith AK, Pantilat SZ, Kluger BM, Mehta AK.   +9 more
europepmc   +1 more source

Optimizing Research Operations and Resource Utilization in ALS Care: Insights From the Tofersen Antisense Oligonucleotide Expanded Access Protocol

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Tofersen is a gene‐targeted therapy for individuals with superoxide dismutase 1 (SOD1) (+) amyotrophic lateral sclerosis (ALS). Prior to U.S. Food and Drug Administration (FDA) approval, tofersen was made available through expanded access protocol.
Alison Wheeler, Kush Mehta, Danica Sanders, Cathy Chin, Hannah Zivalic, Judith Carey, Alexandra McCaffrey, Pravin Pant, Carl Lewenhaupt, Sarah Luppino, Gabriel Jacobs, Shea Golden, Ryan Gifford, Erica Scirocco, Mackenzie Keegan, Munaf Hatem, Taravat Yazdanian, Sanem P. Uysal, Natalie Susco, Shauna Schwartzman, Karen Branch, Kathryn E. Hall, Joanna Barnas, Jenny Lam, Jennifer Hagar, Carol Ann Hannan, Sabrina Paganoni, James D. Berry, Mark Garret, Jennifer Scalia, Suma Babu   +30 more
wiley   +1 more source

Safety and biodistribution of intrathecal administration of mesenchymal stem cells (MSCs) and neurotrophin-releasing nanoparticles in a porcine CSF-guided delivery model for amyotrophic lateral sclerosis (ALS) drug discovery. [PDF]

Sci Rep
Sinderewicz E, Dąbkowska M, Sarnowska A, Staszkiewicz-Chodor J, Mystkowska D, Holak P, Drozd I, Chodkowska-Michalowska M, Rytel M, Paczkowska E, Mycko MP, Machalinski B, Jezierska-Wozniak K.   +12 more
europepmc   +1 more source

At‐Home Versus in‐Clinic Vital Capacity Measurement: Insights From the HEALEY ALS Platform Trial

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Respiratory weakness, typically monitored as vital capacity (VC), is a central feature of amyotrophic lateral sclerosis (ALS). VC is increasingly measured remotely in participants' homes, although in‐clinic assessment remains the standard.
Eric A. Macklin, James D. Berry, Brittney A. Harkey, Lindsay Heyd, Marianne Chase, Hong Yu, Alexander V. Sherman, Derek Dagostino, Gale Kittle, Meghan Hall, Mariah R. Connolly, Kristin Drake, Elisa Giacomelli, Erica Scirocco, Saloni Sharma, Suma Babu, Michael Benatar, Zachary Simmons, Eufrosina Young, Merit E. Cudkowicz, Jeremy Shefner, Sabrina Paganoni, on behalf of the HEALEY ALS Platform Trial Study Group, Eric A. Macklin, Lori B. Chibnik, Douglas Hayden, Po‐Ying Lai, Rachel A. Donahue, Hao‐Wun Chen, Jianing Wang, Melanie Quintana, Benjamin R. Saville, Michelle A. Detry, Joe Marion, Matteo Vestrucci, Anna McGlothlin, Gustavo Alameda, Nithya Mathai, Eduardo Locatelli, Gabriela Lopes, Sabrina Paganoni, Merit Cudkowicz, Doreen Ho, Alexandra McCaffrey, James D. Berry, Suma Babu, Jennifer Scalia, Sarah Luppino, Clotilde Lagier‐Tourenne, Ghazaleh Sadri‐Vakili, Adam Quick, Stephen Kolb, Sarah Heintzman, Senda Ajroud‐Driss, Robert Sufit, April Szymanski, Jonathan Katz, Liberty Jenkins, Daragh Heitzman, Alan Martin, Stanley H. Appel, Simpson) Greene, Jason R. Thonhoff, Sheetal Shroff, Bing Liao, Kevin Felice, Charles Whitaker, Nicholas J. Maragakis, Lora L. Clawson, Alpa Uchil, Kristen M. Riley, JinAe Arneklev, Zachary Simmons, James Grogan, Xiaowei Su, Mansoureh Mamarabadi, Timothy M. Miller, Amber Malcolm, Nicholas Olney, Tracy Bazan, Michael D Weiss, Nassim Rad, Leo H. Wang, Stephen A. Goutman, Eva L. Feldman, Joseph Americo Fernandes, Ezequiel Piccione, Pariwat Thaisetthawatkul, Omar Jawdat, Constantine Farmakidis, Duaa Jabari, Jeffrey Statland, Mamatha Pasnoor, Mazen Dimachkie, Margaret Ayo Owegi, Robert H. Brown, Mehdi Ghasemi, Hajar Houmani, Catherine Douthwright, Kate Daniello, Laura A. Foster, Tuan Vu, Niraja Suresh, Jerrica Farias, I‐Hweii A. Chen, Hristelina Ilieva, Piera Pasinelli, Daniel S. Newman, Ximena Arcila‐Londono, Kara Steijlen, Carlayne E. Jackson, Ratna Bhavaraju‐Sanka, Shafeeq Ladha, Bill Jacobsen, Jourdan Milliard, Robert Bowser, Jeremy M. Shefner, Terry Heiman‐Patterson, Anahita Deboo, James B. Caress, Michael S. Cartwright, Andrea Swenson, Christopher Nance, Ludwig Gutmann, Jinsy Andrews, Julia Yasek, Matthew Harms, Amanda Peltier, Richard Lewis, Matthew Burford, Frank Diaz, Dominic Fee, David Shrilla, Matthew Elliott, Goran Rakocevic, Sarah Jones, Guillermo Solorzano, Richard Bedlack, Xiaoyan Li, Edward J. Kasarskis, Zabeen Mahuwala, Vishakhadatta (Vish) Mathur Kumaraswamy, Lauren Elman, Colin Quinn, Michael Baer, Jeffrey Rosenfeld, David Borg, Karthikeyan Bhuvaneswaran, Jasdeep Kaur, David Walk, Sam Maiser, Seward B. Rutkove, Courtney E. McIlduff, Paul Twydell, Andrew Mundwiler, Eufrosina Young, Jenny A. Meyer, Kristin Johnson, Pooja Rao, Kourosh Rezania, Betty Soliven, Raymond Roos, Namita A. Goyal, Ali A. Habib, Tahseen Mozaffar, Manisha Kak Korb, Jeffrey Mullen, Jeffrey A. Cohen, Elijah Stommel, Nathaniel M Robbins, Michael Benatar, Nathan Carberry, Volkan Granit, Raghav Govindarajan, Vovanti Jones, Jonathan Glass, Christina N. Fournier, Jaimin S. Shah, Bjorn Oskarsson, Said R. Beydoun, Leila Darki, Rodrigo Rodriguez, James P. Wymer, Miguel Chuquilin, Whitney McNeely, Lindsay Zilliox, Montserrat Diaz‐Abad, Peter H. Jin, Chandana Chauhan, Shakti Nayar, Gary L. Pattee, James Bobenhouse, Jennifer Martinez‐Thompson, Nathan P. Staff, Ghazala Hayat, Luisa Arroyave, Abbey Bailey, Jesse Bailey, Victoria Barlow, Allison Bulat, Genevive Changkuon, Marianne Chase, Melissa Cirino, Derek Dagostino, Cristina Deignan, Emma Deirmendjian, Annette De Mattos, Sofia DiStefano, Kristin Drake, Michaela Estes, Kenneth Faulconer, Precious Figueroa‐Szostek, Tessa Garozzo, Brittney A. Harkey, Meredith Gibbons Hasenoehrl, Jennifer Henrique, Natalie Henrique, Samuel Hurwitz, Courtney Igne, Liam Irwin, Katie Jentoft, Boglarka Jordan, Igor Katsovskiy, Olga Kharakozova, Taylor Kolvek, Alexander Korin, Thuong La, Haining Li, Joey Nguyen, Ilya Novak, Ricardo Ortiz, Joe Ostrow, Jaclyn Pagliaro, Jack Palillo, Payal Patel, Janae Patterson, Minh Phan, Najla Popel, Lindsay Pothier, Serena Proueng, Jesse Rosenthal, Alexander V. Sherman, Catherine Small, Natalia Tarasenko, Mirna Thomas, Eric Tustison, Prasha Vigneswaran, Yusra Wahab, Isaac Whitworth, Spencer Wright, Hong Yu, Mariah Connolly, Diana De Santiago, Adrian Felix, Karly Garrett, Meghan Hall, Jenny Hamilton, Kamran Khan, Gale Kittle, Marlee Lovett, Linda Nelson, Marissa Pabon, Diana Rede, Patrick Bolger, Ahmed Fetouh, Joan Woodcook, Cornelia Kamp, Julie Kennedy, Andrew McGarry, Margherita Torti   +269 more
wiley   +1 more source

Amyotrophic Lateral Sclerosis (ALS) Type 8: A Narrative Review. [PDF]

Cureus
McBenedict B, Hauwanga WN, Nezam U, Ko Oo A, Eapi S, Pradhan S, Dang NB, Cher PW, Orsini MA, Lima Pessôa B.   +9 more
europepmc   +1 more source

Comparison of Consumer Smartwatch and Research‐Grade Accelerometer‐Derived Step Counts in Amyotrophic Lateral Sclerosis

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Objective, scalable measures of function are needed in amyotrophic lateral sclerosis (ALS). Research‐grade accelerometers are promising but may be difficult to deploy for prolonged remote monitoring, whereas consumer smartwatches offer a practical alternative. We evaluated the feasibility of long‐term smartwatch monitoring in
Gordon Jewett, Reed Ferber, Colin B. Josephson, Lawrence Korngut, Joon Lee   +4 more
wiley   +1 more source

Amyotrophic Lateral Sclerosis (ALS)-Related Mortality Among World Trade Center-Exposed and Non-World Trade Center-Exposed Rescue and Recovery Workers. [PDF]

Int J Environ Res Public Health
Singh A, Zeig-Owens R, Cannon MF, Moline T, Schwartz T, Prezant DJ.   +5 more
europepmc   +1 more source

A Systematic Review of Attributes Influencing Preferences for Treatments and Interventions in People With Amyotrophic Lateral Sclerosis (ALS). [PDF]

Muscle Nerve
Clift A, Rowen D, Knox L, Griffiths AW, McDermott CJ.   +4 more
europepmc   +1 more source

Usefulness of Information and Communication Technology‐Based Patient Information Sharing System in Supporting Patients With Intractable Neurological Diseases

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT Background Multidisciplinary collaboration is crucial for patients with incurable neurological diseases. However, sharing information among medical staff across institutions is challenging. Our cloud‐based patient information sharing system uses information and communication technology to facilitate the sharing of patient information among ...
Yui Kamijo, Akiyo Hineno, Gaku Okumura, Yoshiki Sekijima, Akinori Nakamura   +4 more
wiley   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source