Results 141 to 150 of about 49,177 (260)

Beyond Antioxidants: The Emerging Role of Nrf2 Activation in Amyotrophic Lateral Sclerosis (ALS). [PDF]

Int J Mol Sci
Sharbafshaaer M, Pepe R, Notariale R, Canale F, Tedeschi G, Tessitore A, Bergamo P, Trojsi F.   +7 more
europepmc   +1 more source

Systematic Review of the Huntington's Disease Drug Development Pipeline, 2014 to 2025

Movement Disorders, EarlyView.
Abstract Background In the past decade, significant advances have improved our understanding of the mechanisms underlying HD pathobiology leading to several putative therapeutic targets for HD. Objective The aim was to describe the Huntington's disease (HD) drug development clinical pipeline.
Pavlina Konstantinova, Jenny Townhill, Juliana Bronzova, Viktoria Andreeva, Swati Sathe, Cristina Sampaio   +5 more
wiley   +1 more source

Symptom-Level Precision Neurology in Amyotrophic Lateral Sclerosis (ALS): Linking Microglial Pruning, Mitochondrial Nicotinamide Adenine Dinucleotide (NAD+) Compensation, and Autophagy Failure Across the Aging Spectrum. [PDF]

Cureus
Cheung N.
europepmc   +1 more source

Amyotrophic lateral sclerosis (ALS)

Journal of Physiotherapy, 2013
openaire   +3 more sources

Simultaneous Acquisition of Magnetic Resonance Elastography (MRE) and Diffusion Tensor Imaging (DTI) Optimized for Human Brain

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Increase clinical acceptance of MRE and DTI by shortening the scan time by half and providing diffusive and mechanical property maps that are inherently co‐registered. This proof‐of‐concept study evaluates the simultaneous DTI‐MRE acquisition in the human brain and compares its results to conventional DTI and MRE measurements.
Shujun Lin, Bradley P. Sutton, Richard L. Magin, Aaron T. Anderson, Dieter Klatt   +4 more
wiley   +1 more source

Stage-Based Communication Rehabilitation in Amyotrophic Lateral Sclerosis (ALS): A Review of Strategies for Enhancing Quality of Life. [PDF]

Arch Intern Med Res
Jackson MC, Azarraga RB, Fraix MP, Agrawal DK.   +3 more
europepmc   +1 more source

SNR‐Efficient Inhomogeneous Magnetization Transfer (ihMT) for Clinical Applications at 7 T

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Inhomogeneous MT (ihMT) is an MRI modality sensitive to Myelin, the lipid‐rich membrane surrounding the axons. A novel ihMT saturation strategy and its associated B1+$$ {\mathrm{B}}_1^{+} $$ correction at UHF are proposed. The aim is to generate a strong ihMT effect within a clinically compatible scan time while complying with SAR ...
Timothy Anderson, Niklas Wallstein, Lucas Soustelle, Thomas Troalen, Gopal Varma, David C. Alsop, Maxime Guye, Guillaume Duhamel, Olivier M. Girard   +8 more
wiley   +1 more source

Greek Registry for Amyotrophic Lateral Sclerosis (ALS-GR): An Observational Cohort of Individuals With ALS Across 11 Specialized Centers in Greece. [PDF]

Eur J Neurol
Liampas I, Kimiskidis VK, Zouvelou V, Veltsista D, Moscholouri A, Triantafyllou E, Daponte A, Xirou S, Sterpi AE, Salakou S, Poulidou V, Arnaoutoglou M, Tsouris Z, Ralli S, Dardiotis E, Papagiannopoulos S, Zampetakis A, Zaganas Ι, Mitsias P, Giannakis A, Konitsiotis S, Kefalas F, Alexiou E, Stoiloudis P, Parissis D, Kiamelidis S, Terzoudi A, Tsivgoulis G, Rentzos M, Chroni E.   +29 more
europepmc   +1 more source

AGRN‐, LRP4‐, MUSK‐Related CMS: Clinical, Neurophysiological, Morphological, Genetic and Pathological Mechanisms

Muscle &Nerve, EarlyView.
ABSTRACT Congenital myasthenic syndromes (CMS) are inherited disorders caused by mutations in genes encoding proteins essential for neuromuscular junction (NMJ) function. Pathogenic variants have been identified in more than 35 genes, underscoring the complexity of synaptic biology and the wide range of mechanisms that can compromise neuromuscular ...
Rocio‐Nur Villar‐Quiles, Damien Sternberg, Marie‐Christine Nougues, Arnaud Isapof, Bruno Eymard, Stéphanie Bauché   +5 more
wiley   +1 more source

To Treat or Not to Treat: A Scoping Review of Speech Treatment for Dysarthria in Amyotrophic Lateral Sclerosis (ALS). [PDF]

Healthcare (Basel)
Whelan BM, Aldridge D, Ruhle J, Whitelock P, Taubert S, Collins A, Kearney E, Charania S, Henderson RD, Wallace SJ, Mitchell C, Stipancic KL, Kuruvilla-Dugdale M, Vogel AP.   +13 more
europepmc   +1 more source