Results 151 to 160 of about 49,177 (260)

Muscle‐Specific Kinase Signaling and Its Therapeutic Potential

Muscle &Nerve, EarlyView.
ABSTRACT The function of the neuromuscular junction (NMJ) is compromised in many neuromuscular diseases (NMDs) such as autoimmune or congenital myasthenia gravis (MG), amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), and muscular dystrophies.
Stine Marie Jensen, Dana L. E. Vergoossen, Maartje G. Huijbers   +2 more
wiley   +1 more source

Reachable Workspace as a Clinical Outcome for Upper Extremity Function: A Narrative Review

Muscle &Nerve, EarlyView.
ABSTRACT Motion sensing technology can be utilized to capture detailed upper extremity (UE) motion to reconstruct an individual's three‐dimensional (3D) reachable workspace (RWS). The RWS can be quantified as relative surface area (RSA), providing an innovative surrogate measure to assess UE mobility and function.
Jay J. Han, Lawrence J. Hayward, Christina Adams, Juan Perez‐Ibarra   +3 more
wiley   +1 more source

Neuroprotective Effects of RNS60 in TDP‐43 Pathology‐Associated Amyotrophic Lateral Sclerosis

Muscle &Nerve, EarlyView.
ABSTRACT Introduction TDP‐43 pathology is broadly observed in the cerebral cortex of patients with amyotrophic lateral sclerosis (ALS). RNS60, an experimental treatment for acute ischemic stroke and ALS, enhanced mitochondrial biogenesis and function in other preclinical models.
Danny R. Vesevick, Supurna Ghosh, Andreas Kalmes, P. Hande Ozdinler, Mukesh Gautam   +4 more
wiley   +1 more source

Embedding Palliative Care Clinicians in ALS Teams Improves ALS Clinicians' Confidence in Their Patient Management and Satisfaction With Palliative Care

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Specialty palliative care (SPC) can improve symptoms and well‐being for people living with ALS. Few studies capture how ALS clinicians utilize or are impacted by SPC. We sought to understand how the presence of SPC clinicians on ALS teams impacts ALS clinicians' referrals to and satisfaction with SPC.
Astrid Grouls, Yaowaree L. Leavell, Ambereen K. Mehta, Gayle Kojimoto, David L. O'Riordan, Samuel Maiser, Benzi M. Kluger, Steven Z. Pantilat, Kara E. Bischoff   +8 more
wiley   +1 more source

Mutant TDP-43 drives impairments in axonal transport and glycolysis in a mouse stem-cell-derived motor neuron model of amyotrophic lateral sclerosis (ALS). [PDF]

Cell Death Dis
Carroll E, Scaber J, Pasniceanu IS, Dafinca R, Gordon D, Candalija A, Talbot K.   +6 more
europepmc   +1 more source

The Flail Limb Syndrome

Muscle &Nerve, EarlyView.
ABSTRACT The flail limb syndrome is primarily a lower motor neuron disorder that initially affects proximal arm muscles (flail arm syndrome—FAS) or distal leg muscles (flail leg syndrome—FLS). Both were recognized early on (1886 for FAS and 1918 for FLS) as somewhat distinct from classic amyotrophic lateral sclerosis (ALS).
Mark B. Bromberg
wiley   +1 more source

Palliative care pathways in Amyotrophic Lateral Sclerosis (ALS): a sequence analysis of health claims data. [PDF]

BMC Palliat Care
Schmidt R, Slotina E, Meissner F, Metelmann M, Ilse B, Vogt V, Freytag A.   +6 more
europepmc   +1 more source

White adipose tissue undergoes pathological dysfunction in the TDP-43^A315T mouse model of amyotrophic lateral sclerosis (ALS). [PDF]

Acta Neuropathol Commun
Benito-Casado C, Durán-Mateos E, Ferrer-Donato Á, García GB, Domínguez-Rubio R, Povedano M, Fernandez-Martos CM.   +6 more
europepmc   +1 more source

No Evidence for an Association Between DIP2B Repeat Expansion and Neurological Disease

Movement Disorders, EarlyView.
Chia‐Ying Ko, Leon Schütz, Thomas Braun, Elena Buena‐Atienza, Nicolas Casadei, Danique Beijer, Ludger Schöls, Tobias B. Haack, Stephan Ossowski, Holger Hengel   +9 more
wiley   +1 more source

The Emotional Experiences of Healthcare Professionals Working in Amyotrophic Lateral Sclerosis: A Systematic Review

Muscle &Nerve, EarlyView.
ABSTRACT Healthcare professionals (HCPs) working with people living with amyotrophic lateral sclerosis (ALS) are often exposed to emotive circumstances including end of life care, trauma, loss, and death. Existing reviews have explored the emotional experiences of people living with ALS and their carers but have largely ignored healthcare staff and the
Young Chan, Sarah Creer, Jess Mere, Alys Wyn Griffiths, Charlotte Wright, Esther V. Hobson, Christopher J. McDermott, Emily J. Mayberry   +7 more
wiley   +1 more source