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Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes
Wong S +8 more
europepmc +1 more source
Centriole Duplication: When PLK4 Meets Ana2/STIL [PDF]
Current Biology, 2014 SummaryPolo-like kinase 4 is known to drive centriole duplication, but the relevant substrate remains elusive. A new study shows that PLK4 phosphorylates a key centriolar component, Ana2/STIL, to initiate centriole ...
Meng-Fu Bryan Tsou, Chii Shyang Fong
exaly +5 more sources
Drosophila Ana2 is a conserved centriole duplication factor [PDF]
Journal of Cell Biology, 2010 In Caenorhabditis elegans, five proteins are required for centriole duplication: SPD-2, ZYG-1, SAS-5, SAS-6, and SAS-4. Functional orthologues of all but SAS-5 have been found in other species. In Drosophila melanogaster and humans, Sak/Plk4, DSas-6/hSas-
Anna Franz +2 more
exaly +5 more sources
The Mechanism of Dynein Light Chain LC8-mediated Oligomerization of the Ana2 Centriole Duplication Factor* [PDF]
Journal of Biological Chemistry, 2014 Centrioles play a key role in nucleating polarized microtubule networks. In actively dividing cells, centrioles establish the bipolar mitotic spindle and are essential for genomic stability.
Kevin C. Slep
exaly +5 more sources
DSas-6 and Ana2 Coassemble into Tubules to Promote Centriole Duplication and Engagement [PDF]
Developmental Cell, 2010 Centrioles form cilia and centrosomes, organelles whose dysfunction is increasingly linked to human disease. Centriole duplication relies on a few conserved proteins (ZYG-1/Sak/Plk4, SAS-6, SAS-5/Ana2, and SAS-4), and is often initiated by the formation ...
Jordan Raff, Helio Roque
exaly +5 more sources
Plk4 Phosphorylates Ana2 to Trigger Sas6 Recruitment and Procentriole Formation [PDF]
Current Biology, 2014 SummaryCentrioles are 9-fold symmetrical structures at the core of centrosomes and base of cilia whose dysfunction has been linked to a wide range of inherited diseases and cancer [1].
Michał Dadlez +2 more
exaly +6 more sources
An ordered pattern of Ana2 phosphorylation by Plk4 is required for centriole assembly
Journal of Cell Biology, 2018 Polo-like kinase 4 (Plk4) initiates an early step in centriole assembly by phosphorylating Ana2/STIL, a structural component of the procentriole. Here, we show that Plk4 binding to the central coiled-coil (CC) of Ana2 is a conserved event involving Polo ...
Brian J Galletta +2 more
exaly +2 more sources
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2023
Centrioles play a central role in cell division by recruiting pericentriolar material (PCM) to form the centrosome. Alterations in centriole number or function lead to various diseases including cancer or microcephaly. Centriole duplication is a highly conserved mechanism in eukaryotes.
Marine Brunet +8 more
openaire +1 more source
Centrioles play a central role in cell division by recruiting pericentriolar material (PCM) to form the centrosome. Alterations in centriole number or function lead to various diseases including cancer or microcephaly. Centriole duplication is a highly conserved mechanism in eukaryotes.
Marine Brunet +8 more
openaire +1 more source