Results 171 to 180 of about 116,695 (256)

Case Report: Reopening the anabolic window - romosozumab added to ongoing denosumab for severe osteoporosis in two kidney transplant recipients. [PDF]

open access: yesFront Endocrinol (Lausanne)
Barbuto S   +9 more
europepmc   +1 more source

Pretreatment Cachexia Index Is Associated With Severe Treatment Toxicity and Overall Survival in HPV‐Negative Head and Neck Squamous Cell Carcinoma

open access: yesHead &Neck, EarlyView.
ABSTRACT Introduction Cancer cachexia is characterized by skeletal muscle loss, poor nutrition, and systemic inflammation and is common in head and neck cancer. We evaluated whether the Cachexia Index (CXI) predicts treatment toxicity and survival in HPV‐negative HNSCC.
Gianluca Savoia   +11 more
wiley   +1 more source

Measuring Temporal Variations of Nucleotide Pools in Microbial Granular Biofilm

open access: yesHelvetica Chimica Acta, EarlyView.
The developed metabolomics workflow enables quantification of energy nucleotides in complex microbial biofilms. The method provides a foundation for investigating rapid metabolic responses to dynamic environmental conditions. ABSTRACT Microbial communities often face environmental fluctuations that occur on timescales much shorter than their growth ...
Jitske M. van Ede   +3 more
wiley   +1 more source

Gut virome orchestrates nitrogen partitioning between the host and microbiome

open access: yesiMeta, EarlyView.
Under normal protein intake, lytic phages promote bacterial turnover, releasing microbial nitrogen that can be assimilated by the host and thereby revealing phage‐mediated lysis as a potential pathway for host nutrient acquisition. Under protein restriction, however, phages shift toward a lysogenic strategy, reducing bacterial death and microbial ...
Shujie Xu   +7 more
wiley   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

open access: yesiNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang   +5 more
wiley   +1 more source

Perspectives of High‐Resolution Mass Spectrometry in Soil Science

open access: yesJournal of Plant Nutrition and Soil Science, EarlyView.
ABSTRACT Soil biogeochemical research requires specific, sensitive, and accurate methods to identify and quantify organic molecules in order to trace biochemical processes and assess element cycling in complex, heterogenous systems. High‐resolution mass spectrometry (HRMS) has evolved into a transformative tool for unraveling the complex chemical ...
Bruno Glaser   +11 more
wiley   +1 more source

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