Results 191 to 200 of about 116,695 (256)

Testosterone Therapy and Tendon Injury: Clinical Evidence, Biological Mechanisms, and Sports Medicine Implications. [PDF]

Cureus
Farzam K.
europepmc   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Grip strength as a systems biomarker of aging: neuromuscular junction constraints and biomarker decoupling in gene therapy. [PDF]

Front Aging
Sewell PE, Jensen C.
europepmc   +1 more source

A proposal for individualized administration of energy and protein in the critically ill with obesity

Nutrition in Clinical Practice, EarlyView.
Abstract The increasing prevalence of obesity has transformed intensive care and nutritional therapy of patients with obesity from a specialized problem to standard care. The dilemma in providing nutrition to critically ill patients with obesity is that current and historical nutritional guideline recommendations are based on expert opinion, are ...
K. Georg Kreymann, Geraldine de Heer, Arved Weimann   +2 more
wiley   +1 more source

Endocrine therapy‐induced cancer‐related fatigue in hormone‐dependent malignancies: Mechanisms, impact, and management strategies

Precision Medical Sciences, EarlyView.
Multipathway schematic of endocrine therapy–induced cancer‐related fatigue. Endocrine interventions trigger four interacting mechanisms—neuroendocrine dysregulation, systemic inflammation, energy‐metabolic failure, and psycho‐behavioral amplification—that culminate in the multidimensional CRF phenotype.
Jiajing Jiang, Jun Lu, Sen Qin, Ruzhou Chen, Qiuchen Zhang, Lvqi He, Yubei Li, Jingyao Yan   +7 more
wiley   +1 more source

Sarcopenia and Skeletal Muscle Dysfunction in Liver Cirrhosis: Clinical Perspectives of Myostatin Inhibition. [PDF]

Biomedicines
Sukocheva O, Harding D, Ow TW, Tse E.
europepmc   +1 more source

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

Phytotherapy Research, EarlyView.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi, Sina Vossoughinia, Zahra Yazdanpanah, Hossein Sobhani, Jalileh Jalali, Mahboobeh Ghasemzadeh Rahbardar   +5 more
wiley   +1 more source

Sequential administration of sclerostin antibody and parathyroid hormone differentially modulates fracture healing in a murine tibial osteotomy model. [PDF]

PLoS One
Mihara A, Yukata K, Nishida N, Seto T, Iwanaga R, Fujii K, Uehara K, Saeki Y, Ohgi J, Tsuji S, Asagiri M, Sakai T.   +11 more
europepmc   +1 more source

Oxidative stress‐driven metabolic reprogramming defines two subtypes of cutaneous melanoma

VIEW, EarlyView.
Cutaneous melanoma exhibits substantial molecular heterogeneity, and metabolic reprogramming may contribute to differences in tumor behavior and treatment response. In this study, we integrated multi‐omics data from SKCM cohorts to identify two metabolism‐associated subtypes with distinct oxidative stress profiles, immune microenvironments, prognostic ...
Qikun Gao, Ziyi Liu, Ying Xu
wiley   +1 more source

HIF-PH Inhibitor Promotes Stabilization of HIF-1α via Inhibition of Its Degradation and Exerts Chondroprotective Effects in a Rat Osteoarthritis Model. [PDF]

Int J Mol Sci
Nakamura K, Fujii Y, Arai Y, Nakagawa S, Inoue A, Cha R, Sugie K, Hayashi K, Saito T, Kishida T, Mazda O, Takahashi K.   +11 more
europepmc   +1 more source