Results 1 to 10 of about 241,016 (306)

Therapeutic Effect of Targeting Branched‐Chain Amino Acid Catabolic Flux in Pressure‐Overload Induced Heart Failure [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Branched‐chain amino acid (BCAA) catabolic defect is an emerging metabolic hallmark in failing hearts in human and animal models. The therapeutic impact of targeting BCAA catabolic flux under pathological conditions remains understudied ...
Mengping Chen, Chen Gao, Jiayu Yu, Shuxun Ren, Menglong Wang, R. Max Wynn, David T. Chuang, Yibin Wang, Haipeng Sun   +8 more
doaj   +4 more sources

Melatonin Maintains Anabolic-Catabolic Equilibrium and Regulates Circadian Rhythm During Osteoarthritis Development in Animal Models: A Systematic Review and Meta-analysis

Frontiers in Pharmacology, 2021
Background: The driving force behind osteoarthritis (OA) pathogenesis is an anabolic-catabolic (a/c) imbalance. Melatonin (MT) is a key player in maintaining a/c stability and mitigates OA pathogenesis, but mechanisms underlying its effects remain poorly
Dewan Md. Sumsuzzman, Dewan Md. Sumsuzzman, Dewan Md. Sumsuzzman, Dewan Md. Sumsuzzman, Jeonghyun Choi, Jeonghyun Choi, Jeonghyun Choi, Zeeshan Ahmad Khan, Zeeshan Ahmad Khan, Zeeshan Ahmad Khan, George Kamenos, George Kamenos, George Kamenos, Yonggeun Hong, Yonggeun Hong, Yonggeun Hong, Yonggeun Hong, Yonggeun Hong   +17 more
doaj   +1 more source

Perioperative catabolism [PDF]

Canadian Journal of Anesthesia/Journal canadien d'anesthésie, 2015
This article reviews the pathophysiology, clinical relevance, and therapy of the catabolic response to surgical stress.The key clinical features of perioperative catabolism are hyperglycemia and loss of body protein, both metabolic consequences of impaired insulin function.
Thomas, Schricker, Ralph, Lattermann
openaire   +2 more sources

Senkyunolide A inhibits the progression of osteoarthritis by inhibiting the NLRP3 signalling pathway

Pharmaceutical Biology, 2022
Context Osteoarthritis (OA) is a degenerative disease. Senkyunolide A (SenA) is an important phthalide from Ligusticum chuanxiong Hort (Umbelliferae) with anti-spasmodic and neuroprotective effects.Objective We explored the effect of SenA on IL-1β ...
Minglei Shao, Dongwei Lv, Kai Zhou, Haijun Sun, Zhitao Wang   +4 more
doaj   +1 more source

Pregnancy in an adolescent with maple syrup urine disease: Case report

Molecular Genetics and Metabolism Reports, 2021
Maple syrup urine disease (MSUD, MIM #248600) is an autosomal recessive metabolic disorder that results in elevation of the branched-chain amino acids (BCAA) leucine, isoleucine, and valine.
Michelle E. Abadingo, Mary Ann R. Abacan, Jeanne Ruth U. Basas, Carmencita D. Padilla   +3 more
doaj   +1 more source

Biomarkers Correlate With Body Composition and Performance Changes Throughout the Season in Women's Division I Collegiate Soccer Players

Frontiers in Sports and Active Living, 2020
The purpose of this study was to evaluate the effects of a competitive soccer season on biomarkers and performance metrics in order to determine the correlation between changes in biomarkers, body composition, and performance outcomes.
Bridget A. McFadden, Bridget A. McFadden, Alan J. Walker, Alan J. Walker, Michelle A. Arent, Michelle A. Arent, Brittany N. Bozzini, Brittany N. Bozzini, David J. Sanders, Harry P. Cintineo, Harry P. Cintineo, Marissa L. Bello, Shawn M. Arent, Shawn M. Arent   +13 more
doaj   +1 more source

Modulation of Perlecan Protein towards Chondrocyte Secretion Factors at the Articular Cartilage in Hyperglycemic Animal Model [PDF]

Journal of Pure and Applied Chemistry Research, 2019
High carbohydrate influences the cartilage microcellular environment and chondrocytes. Perlecan (HSPG2) conducts an essential role as chondrocytes mechano-transducer and chondrocytes secretion factors. This research aims to fulfill the research gap about
Ibrahim Njoto, Fatchiyah Fatchiyah, Kusworini Handono, Abdurrachman Abdurrachman, Djoko W. Soeatmadji, Handono Kalim   +5 more
doaj   +1 more source

Growth Hormone(s), Testosterone, Insulin-Like Growth Factors, and Cortisol: Roles and Integration for Cellular Development and Growth With Exercise

Frontiers in Endocrinology, 2020
Hormones are largely responsible for the integrated communication of several physiological systems responsible for modulating cellular growth and development.
William J. Kraemer, Nicholas A. Ratamess, Wesley C. Hymer, Bradley C. Nindl, Maren S. Fragala   +4 more
doaj   +1 more source

Re-routing of Sugar Catabolism Provides a Better Insight Into Fungal Flexibility in Using Plant Biomass-Derived Monomers as Substrates

Frontiers in Bioengineering and Biotechnology, 2021
The filamentous ascomycete Aspergillus niger has received increasing interest as a cell factory, being able to efficiently degrade plant cell wall polysaccharides as well as having an extensive metabolism to convert the released monosaccharides into ...
Tania Chroumpi, Mao Peng, Lye Meng Markillie, Hugh D. Mitchell, Carrie D. Nicora, Chelsea M. Hutchinson, Vanessa Paurus, Nikola Tolic, Chaevien S. Clendinen, Galya Orr, Scott E. Baker, Miia R. Mäkelä, Miia R. Mäkelä, Ronald P. de Vries   +13 more
doaj   +1 more source

Thermodynamic modelling of synthetic communities predicts minimum free energy requirements for sulfate reduction and methanogenesis [PDF]

, 2020
Microbial communities are complex dynamical systems harbouring many species interacting together to implement higher-level functions. Among these higher-level functions, conversion of organic matter into simpler building blocks by microbial communities ...
Chen, Jing, Delattre, Hadrien, Soyer, Orkun S., Wade, Matthew J.   +3 more
core   +1 more source