Results 11 to 20 of about 241,016 (306)

Inhibition of NADPH Oxidases Prevents the Development of Osteoarthritis

Antioxidants, 2022
Increased oxidative stress in osteoarthritis (OA) cartilage mediates catabolic signal transduction leading to extracellular matrix degradation and chondrocyte apoptosis.
Jin Han, Donghwi Park, Ji Young Park, Seungwoo Han   +3 more
doaj   +1 more source

Basal Mild Dehydration Increase Salivary Cortisol After a Friendly Match in Young Elite Soccer Players

Frontiers in Physiology, 2018
A soccer match induce changes in physiological stress biomarkers as testosterone (T), cortisol (C), and testosterone:cortisol (T:C) ration. Hydration state may also modulate these hormones, and therefore may alter the anabolic/catabolic balance in ...
Mauricio Castro-Sepulveda, Rodrigo Ramirez-Campillo, Felipe Abad-Colil, Camila Monje, Luis Peñailillo, Jorge Cancino, Hermann Zbinden-Foncea   +6 more
doaj   +1 more source

Position-Specific Metabolic Probing and Metagenomics of Microbial Communities Reveal Conserved Central Carbon Metabolic Network Activities at High Temperatures

Frontiers in Microbiology, 2019
Temperature is a primary driver of microbial community composition and taxonomic diversity; however, it is unclear to what extent temperature affects characteristics of central carbon metabolic pathways (CCMPs) at the community level.
Scott C. Thomas, Kevin O. Tamadonfar, Cale O. Seymour, Dengxun Lai, Jeremy A. Dodsworth, Senthil K. Murugapiran, Emiley A. Eloe-Fadrosh, Paul Dijkstra, Brian P. Hedlund, Brian P. Hedlund   +9 more
doaj   +1 more source

Poster 196: Articular Chondrocytes in Hip Femoroacetabular Impingement Present a Less Catabolic Phenotype than Late Stage of Disease

Orthopaedic Journal of Sports Medicine, 2022
Objectives: Pathophysiologic mechanisms during osteoarthritis (OA) have been primarily identified using tissues harvested from end stage of disease. However, it is likely that the disease-initiating molecular changes have already occurred in early-stage ...
Tomoyuki Kamenaga MD, PhD, Jie Shen, May Wu, Robert Brophy MD, John Clohisy MD, Regis O’Keefe, Cecilia Pascual Garrido MD, PhD   +6 more
doaj   +1 more source

Microbial catabolic activities are naturally selected by metabolic energy harvest rate [PDF]

, 2015
The fundamental trade-off between yield and rate of energy harvest per unit of substrate has been largely discussed as a main characteristic for microbial established cooperation or competition.
AA van de Graaf, AJM Stams, B Schink, B Schink, BE Jackson, DJ Batstone, E Costa, G Ruiz, H König, HJ Morowitz, HV Westerhoff, IA van de Leemput, Irina D Ofiţeru, J Pérez, J Rodríguez, J-U Kreft, JJ Heijnen, JJ Heijnen, JJ Heijnen, JJ Vallino, JL Snoep, Jorge Rodríguez, Juan M Lema, K Manchester, KB Andersen, KL Roberts, L Appels, L Margulis, MF Temudo, N Lane, N Lane, P López-García, Pa Murray, R González-Cabaleiro, R Kleerebezem, R Pascal, RC MacLean, Rebeca González-Cabaleiro, S An, S Schuster, S Winogradsky, T Pfeiffer, T Pfeiffer, TG Waddell, TM Hoehler, U von Stockar, X Wang, Y Liu, Y Pan, Y Pan, Y Pan   +50 more
core   +2 more sources

Higher IL-6 and IL6:IGF Ratio in Patients with Barth Syndrome

Journal of Inflammation, 2012
Background Barth Syndrome (BTHS) is a serious X-linked genetic disorder associated with mutations in the tafazzin gene (TAZ, also called G4.5). The multi-system disorder is primarily characterized by the following pathologies: cardiac and skeletal ...
Wilson Lori D, Al-Majid Sadeeka, Rakovski Cyril S, MD Christina D   +3 more
doaj   +1 more source

Dexamethasone: chondroprotective corticosteroid or catabolic killer? [PDF]

European Cells & Materials, 2019
While glucocorticoids have been used for over 50 years to treat rheumatoid and osteoarthritis pain, the prescription of glucocorticoids remains controversial because of potentially harmful side effects at the molecular, cellular and tissue levels.
R Black, AJ Grodzinsky
doaj   +1 more source

Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model [PDF]

, 2013
© 2013 Peake et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Achan, P, Bader, DL, Chowdhury, TT, Hobbs, AJ, Moyes, AJ, Peake, N, Ramachandran, M, Salter, DM, Su, N   +8 more
core   +3 more sources

Biodegradation of the herbicide mecoprop-p with soil depth and its relationship with class III tfdA genes [PDF]

, 2010
Mecoprop-p [(R)-2-(4-chloro-2-methylphenoxy) propanoic acid) is widely used 37 in agriculture and poses an environmental concern because of its susceptibility to leach 38 from soil to water.
Alexander, Bending, Bending, Buss, Bælum, Bælum, Carsten S. Jacobsen, Environment Agency, European Environment Agency, Fomsgaard, Fredslund, Fulthorpe, Gary D. Bending, Helweg, Huong, Itoh, Itoh, Jacob Bælum, Johannesen, Johnson, Kitagawa, Kristensen, Lee, Liz J. Shaw, M Sonia Rodríguez-Cruz, McGowan, Parker, Pemberton, Reffstrup, Rodriguez-Cruz, Sakai, Sebastian R. Sørensen, Shaw, Shengjing Shi, Stanier, Suwa, Thomas Aspray, Tonso, Zakaria   +38 more
core   +1 more source

Decrease of disease‐related metabolites upon fasting in a hemizygous knock‐in mouse model (Mut‐ko/ki) of methylmalonic aciduria

JIMD Reports, 2021
Methylmalonyl‐CoA mutase (MMUT) is part of the propionyl‐CoA catabolic pathway, responsible for the breakdown of branched‐chain amino acids, odd‐chain fatty acids and the side‐chain of cholesterol.
Marie Lucienne, Déborah Mathis, Nathan Perkins, Ralph Fingerhut, Matthias R. Baumgartner, D. Sean Froese   +5 more
doaj   +1 more source