Results 121 to 130 of about 29,623 (261)

Higher Serum Testosterone Protects Against the Development of Type 2 Diabetes in Middle‐Aged but Not Older Men

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Low serum testosterone concentration has been reported to be causally linked to the risk of Type 2 diabetes (T2D). The benefit of T2D protection has been demonstrated to continue up to serum testosterone concentrations of 461 ng/dL (16 nmol/L).
Mahesh M. Umapathysivam, Andrew D. Vincent, Jason Tan, Alebachew Ashagre, David Jesudason, Gary Wittert   +5 more
wiley   +1 more source

Design, synthesis and biological evaluation of novel pyrimidine derivatives as bone anabolic agents promoting osteogenesis via the BMP2/SMAD1 signaling pathway. [PDF]

RSC Med Chem
Rastogi SK, Khanka S, Kumar S, Lakra A, Rathur R, Sharma K, Bisen AC, Bhatta RS, Kumar R, Singh D, Sinha AK.   +10 more
europepmc   +1 more source

Minimal Residual Disease as a Biological Trait: Rethinking Disease Persistence in Hematologic Malignancies

European Journal of Haematology, EarlyView.
ABSTRACT Minimal residual disease (MRD) has emerged as a central biomarker in hematologic malignancies, enabling highly sensitive detection of tumor persistence beyond conventional morphologic assessment and serving as an increasingly important surrogate endpoint in clinical trials.
Santino Caserta, Enrica Antonia Martino, Ernesto Vigna, Mamdouh Skafi, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Graziella D'Arrigo, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Maria Eugenia Alvaro, Giovanni Tripepi, Fortunato Morabito, Massimo Gentile   +14 more
wiley   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Mitochondrial transfer in acute myeloid leukaemia and multiple myeloma: Mechanisms, consequences and potential therapeutic opportunities

The FEBS Journal, EarlyView.
Mitochondria can be transferred from bone marrow cells to cancer cells in acute myeloid leukaemia and multiple myeloma, boosting tumour energy production, growth, and drug resistance. This review highlights key transfer mechanisms and shows how targeting mitochondrial movement and dynamics may offer new therapeutic strategies to limit cancer ...
Ebubechukwu Nwarunma, Mark T. S. Williams   +1 more
wiley   +1 more source

Circadian disruption elicits sex‐specific gut microbiota, endocannabinoidome, and lipid mediator responses

The FEBS Journal, EarlyView.
Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki, Timothy D. Niepokny, Tina Khalilzadehsabet, Elizabeth Dumais, Nicolas Flamand, Vincenzo Di Marzo, Eric M. Mintz, Cristoforo Silvestri   +7 more
wiley   +1 more source

Bone Bridge Effect for the Treatment of Acute Osteoporotic Vertebral Compression Fractures: A Multistrategic Approach Using an Anabolic Agent. [PDF]

Yonsei Med J
Yoon JY, Kim SM, Moon SH, Kim HS, Suk KS, Park SY, Kwon JW, Lee BH.   +7 more
europepmc   +1 more source

Bone health in adults with non‐ambulatory neuromuscular disorders: scoping review of risk factors, diagnosis and management

Internal Medicine Journal, EarlyView.
Abstract Background Non‐ambulatory adults have an increased risk of osteoporosis and fractures due to reduced weight‐bearing and diminished neuromuscular stimulation, resulting in substantial morbidity and mortality. Aims This scoping review aimed to systematically evaluate risk factors, diagnostic indicators and management strategies for optimising ...
Thomas Bailey, Carolyn Droste, John A. Eisman, Steven G. Faux, Arnagretta Hunter   +4 more
wiley   +1 more source

Sequential Versus Step-Therapy Approaches for Osteoporosis Management in Orthopedic Subspecialties. [PDF]

Curr Osteoporos Rep
Salman SG, Phadke R, Burnett J, Walsh J.
europepmc   +1 more source

Muscle Mass Is a Better Predictor of Survival in Dogs With Chronic Kidney Disease Compared to Body Condition Score

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Monitoring prognostic factors, such as body weight, is important to assess the effectiveness of therapies in patients with chronic kidney disease (CKD) and estimate the survival rate (SR). As established in the literature, both body condition score (BCS) and muscle mass score (MMS), when analysed individually, show a positive correlation with ...
Thiago Henrique Annibale Vendramini, Pedro Henrique Marchi, Vivian Pedrinelli, Andressa Rodrigues Amaral, Laís Oyama Cotrim Lima, Bianca Petermann Moretti, Natália Manuela Cardoso de Oliveira, Cristiana F. F. Pontieri, Juliana T. Jeremias, Júlio Cesar de Carvalho Balieiro, Marcio Antonio Brunetto   +10 more
wiley   +1 more source