Results 161 to 170 of about 57,256 (260)

Comparison of the Clinical Efficacy of Anabolic Agents and Bisphosphonates in the Patients With Osteoporotic Vertebral Fracture: Systematic Review and Meta-analysis of Randomized Controlled Trials. [PDF]

Neurospine
Jeon I, Park SB, Moon BJ, Choi M, Kuh SU, Kim J.   +5 more
europepmc   +1 more source

Effects of Glucagon‐Like Peptide‐1 Receptor Agonists (Mono and Combination Therapy) on Energy Expenditure: A Scoping Review

Obesity Reviews, EarlyView.
ABSTRACT Introduction Weight loss results in reduced energy expenditure (EE) due to body composition alterations (e.g., fat‐free mass and fat mass losses) and mass‐independent adaptations in EE (e.g., hormones). Glucagon‐like peptide‐1 receptor agonists (GLP‐1RA) are indicated for obesity management; however, their effects on EE remain unclear ...
Flavio T. Vieira, ZhiDi Deng, Manfred J. Muller, Giovanna G. L. Bergamasco, Sarah Cawsey, Melania Manco, Steven B. Heymsfield, Carla M. Prado, Andrea M. Haqq   +8 more
wiley   +1 more source

Design, synthesis and biological evaluation of novel pyrimidine derivatives as bone anabolic agents promoting osteogenesis via the BMP2/SMAD1 signaling pathway. [PDF]

RSC Med Chem
Rastogi SK, Khanka S, Kumar S, Lakra A, Rathur R, Sharma K, Bisen AC, Bhatta RS, Kumar R, Singh D, Sinha AK.   +10 more
europepmc   +1 more source

Combined Effects of Romosozumab and Zoledronate on the Development of Osteonecrosis of the Jaw

Oral Diseases, EarlyView.
ABSTRACT Objective This study aimed to assess the occurrence of medication‐related osteonecrosis of the jaw (MRONJ) in mice following the sequential administration of romosozumab and zoledronate and to confirm their inhibitory effects on osteoclast differentiation in vitro.
Hae‐Seo Park, Shihyun Kim, Seo‐Yeong An, Reuben H. Kim, Jongho Choi, Moon‐Young Kim   +5 more
wiley   +1 more source

The Role of Piezo 1 in the Study of Intervertebral Disc Degeneration: Phenotype, Mechanism and Treatment

Orthopaedic Surgery, EarlyView.
As the key mechanotransducer in IVDD, Piezo1 orchestrates region‐specific degeneration across NP (senescence/ECM dysregulation), AF (apoptosis), and CEP (inflammation). This review integrates mechanistic pathways and assesses multimodal therapeutic targeting (pharmacologic/genetic/nutritional) to restore disc homeostasis.
Guangye Li, Chaoqun Feng, Haoyun Huang, Junwen Deng, Fei Yang, Rigao Chen   +5 more
wiley   +1 more source

Assessing P1NP/β‐CTX as Potential Risk Factors Associated With Different Subtypes of Fragile Hip Fracture in Elderly Patients

Orthopaedic Surgery, EarlyView.
By exploring the correlation between P1NP/β‐CTX and the subtypes of hip fractures, this study attempts to establish these two bone turnover markers as predictive indicators and postoperative complication monitors for such common fractures in the elderly.
Lijia Zhang, Jiabao Ju, Yichong Zhang, Chen Xiong, Baozhong Zhang, Jia Zhang, Peng Gao, Yanhua Wang, Xiaomeng Zhang, Jianguo Zhang   +9 more
wiley   +1 more source

Distinct Defence Mechanisms of Allelopathic Rice Against Quinclorac‐Susceptible and ‐Resistant Barnyardgrass: Involvement of Specific Metabolites and Rhizosheath Microbiota

Plant Biotechnology Journal, EarlyView.
ABSTRACT Allelopathic rice is increasingly recognised as a promising strategy for sustainable weed management. Resistance to the herbicide quinclorac is widespread in barnyardgrass, but it remains unclear whether allelopathic rice exerts the same defence against herbicide‐susceptible and ‐resistant barnyardgrass. We conducted integrated transcriptomic,
Shuyan Li, Qiling Yan, Jianhua Tong, Yongfeng Li, Lianyang Bai, Qiong Peng   +5 more
wiley   +1 more source

Comparative efficacy and safety of antiresorptive and anabolic therapies for male osteoporosis: an updated Bayesian network meta-analysis. [PDF]

Front Endocrinol (Lausanne)
Li Z, Zhang L, Xue C, Lu C, Wang L.
europepmc   +1 more source

Oral wound healing in the elderly: Mechanisms, challenges, and innovations

Periodontology 2000, EarlyView.
Abstract Objective This narrative synthesizes current knowledge on the biological mechanisms, clinical challenges, and regenerative innovations for optimizing intraoral wound healing in the elderly. Methods Narrative review of preclinical and clinical studies addressing age‐related changes in the four canonical wound‐healing phases (hemostasis ...
Ann M. Decker, Sandra H. Stuhr, Gustavo Avila‐Ortiz, Andrea Pilloni, Lorenzo Marini, Rogerio Castilho, Beth I. Wallace, Yvonne L. Hernandez‐Kapila   +7 more
wiley   +1 more source

Non-medical use of exogenous testosterone and anabolic-androgenic substances in young men: health, psychological, and fertility consequences. [PDF]

Front Endocrinol (Lausanne)
Kowalik K, Harasny P, Kaliczyńska L, Reweda-Kwiatkowski K, Starzyński D, Pawlak M, Waloryszak A, Ptak M, Modrzejewski A, Lisman D.   +9 more
europepmc   +1 more source