Results 71 to 80 of about 3,709,556 (294)
BMEMat, EarlyView.The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...
Wen Zhang +7 more
wiley +1 more source
EMBO Molecular Medicine, 2016 Bone anabolic agents promoting bone formation and rebuilding damaged bones would ideally overcome the limitations of anti‐resorptive therapy, the current standard prescription for osteoporosis.
Hyun‐Yi Kim +10 more
doaj +1 more source
Acta Scientiarum. Health Sciences, 2015 Anabolic androgenic-steroids (AAS) include a broad class of synthetic derivatives of testosterone, being nandrolone decanoate the most widely used in sports environment.
Marcela de Paiva Foletto +5 more
doaj +1 more source
Biomaterial design strategies for enhancing mitochondrial transplantation therapy
BMEMat, EarlyView.Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang +12 more
wiley +1 more source
Self‐Calibrating Ratiometric DNA Aptamer Probe for Quantitative ATP Imaging in Living Cells
Chemistry – A European Journal, EarlyView.We developed the RFA–ECHO probe, an internally calibrated ATP sensor that remains responsive across millimolar ATP levels. Its self‐correcting Cy5/ECHO ratio ensures accurate quantification independent of probe uptake. Compared with FRET‐based sensors, it yields a robust ratiometric shift, distinguishing high‐ATP cancer cells from normal ones, enabling
Yunsong Xu +5 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Thiopurine methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15) are key enzymes that catabolize thiopurines. Decreased or no‐function alleles in TPMT and NUDT15 are associated with reduced or no enzyme activity and predictive of pronounced adverse effects, including severe myelosuppression, that may occur among individuals treated with standard ...
Maud Maillard +18 more
wiley +1 more source
Comprehensive Evaluation of Treatment Patterns in Postmenopausal Patients with Osteoporosis without Fractures: Insights from Tertiary Care Institutions and Nationwide OMOP-CDM Data [PDF]
Endocrinology and MetabolismBackground Osteoporosis is a global health concern. Despite emerging treatment options for this condition, limited data are available on hospital practices in South Korea.
Kyoung Jin Kim +9 more
doaj +1 more source
Online information and availability of three doping substances (anabolic agents) in sports: role of pharmacies. [PDF]
Front Pharmacol, 2023 Garcia JF +10 more
europepmc +1 more source
Investigations Into the Human Metabolism of Trestolone (7α‐Methyl‐19‐Nortestosterone)
Drug Testing and Analysis, EarlyView.As the known metabolites of 7α‐methyl‐19‐nortestosterone (MENT), M1 and M2, suffer from chromatographic issues under routine doping control conditions, the human metabolism of MENT was reinvestigated. From the numerous new metabolites detected, especially, M5 and M10 were identified as the most promising candidates to be implemented into routine ...
Thomas Piper +2 more
wiley +1 more source
Acta Scientiarum. Health Sciences, 2010 Spermatogenesis is a complex, highly organized and coordinated process that results in the production of male gametes. This process is influenced by a number of drugs that enhance physical performance, which have been used mainly by young people ...
Marcela de Paiva Foletto +4 more
doaj