Results 121 to 130 of about 235,143 (310)

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

CKD / Anaemia [PDF]

Clinical Kidney Journal, 2011
S. D. Roger, A. Bock, F. Carrera, K.-U. Eckardt, C. Gaillard, D. Van Wyck, B. Roubert, J. Nolen, I. C. Macdougall, I. D. Macdougall, A. Bock, F. Carrera, K.-U. Eckardt, C. Gaillard, D. Van Wyck, B. Roubert, J. Nolen, S. D. Roger, G. Mircescu, C. Capusa, D. Margarit, L. Barsan, V. Blaga, S. Stancu, C. S. Hartman, I. R. Shalwitz, R. A. Shalwitz, L. London, Y. Segev, D. Landau, A. Vlachopanou, P. Nikolopoulos, T. Bampali, V. Foulidis, K. Katopodis, C. Gouva   +35 more
openaire   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Trimester-specific trends in gestational anaemia and associations with neonatal outcomes: a retrospective facility-based study in Ghana

Discover Public Health
Objective The timing of anaemia onset during pregnancy plays a critical role in determining its impact on neonatal outcomes. However, research on trimester-specific anaemia trends and their implications for adverse newborn outcomes has been inconclusive.
Jevaise Aballo, Martin Nyaaba Adokiya, Michael Boah   +2 more
doaj   +1 more source

Preoperative anaemia [PDF]

British Journal of General Practice, 2008
openaire   +2 more sources

Remote Activation of Spinal TRPV1 by Magnetic Nanocubes Confers Cardioprotection Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Fe‐based magnetic nanocubes conjugated with TRPV1 antibodies (FeNCs‐TRPV1) are developed for the specific targeting of TRPV1 channels. Intraspinally injected FeNCs‐TRPV1 induces TRPV1 desensitization in rats exposed to repetitive and transient ACMF.
Xueying Cheng, Shuangyu Liu, Yu Zhang, Kang Peng, Muge Qile, Chao Wu, Mengyun Dou, Liu Liu, Na Yang, Rui Liu, Guiyang Zhang, Liangping Ni, Gaolin Liang, Fang Yang, Ye Zhang, Shufang He   +15 more
wiley   +1 more source

Machine Learning‐Guided Engineering of Protein Phase Separation Properties in Immune Regulation

Advanced Science, EarlyView.
PScalpel, a machine learning model integrating protein structure extraction, graph contrastive learning, and a genetic algorithm, guides the engineering of protein phase separation ability. It adopts transfer learning methods to provide predictive recommendations for protein phase separation ability changes through single amino acid mutations in a ...
Chenqiu Zhang, Jia Wang, Zhe Wang, Liyan Zhu, Sihui Cai, Luzhi Zhan, Haorui Liang, Yaoxing Wu, Jianqiang Li, Jun Cui   +9 more
wiley   +1 more source

Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993–2005

Public Health Nutrition, 2009
E. McLean, M. Cogswell, I. Egli, D. Wojdyla, B. de Benoist   +4 more
semanticscholar   +1 more source

Exploring the Vasculitis‐Tumors Link: Epidemiological Patterns, Mechanistic Insights, and Clinical Implications

Advanced Science, EarlyView.
This review outlines association between vasculitis and malignancies and provides practical value for clinicians in distinguishing primary vasculitis from malignancy‐associated forms and optimizing patient surveillance, improving recognition of tumor‐associated vasculitis to reduce the risk of misdiagnosis, supporting more accurate clinical decision ...
Xiaofei Shi, Zhijiao Li, Xin Ma, Bei Zhang, Xinfeng Wu, Hua Fan, Rongzeng Liu, Hongwei Jiang, Cong‐Qiu Chu   +8 more
wiley   +1 more source

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source