Results 51 to 60 of about 41,207 (297)

Exercise tolerance in type - 2 male diabetics

South African Journal of Physiotherapy, 2002
The objective of this study was to compare the exercisetolerance of a set of male diabetic Nigerians with non-diabetic male subjects. Ten male Type-2 diabetics between the ages of 35 and 50 years in good glycaemic control and ten male non-diabetic ...
D. O. Odedbiyi, A. E. Ohwovoriole
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Exercise Training in Children and Adolescents with Cystic Fibrosis: Theory into Practice

International Journal of Pediatrics, 2010
Physical activity and exercise training play an important role in the clinical management of patients with cystic fibrosis (CF). Exercise training is more common and recognized as an essential part of rehabilitation programmes and overall CF care ...
Craig A. Williams, Christian Benden, Daniel Stevens, Thomas Radtke   +3 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Effects of caffeine on anaerobic exercise [PDF]

, 2004
The effects of caffeine on endurance exercise have been well researched with the majority of studies reporting positive effects. However, few studies exist examining the potential ergogenic effects of caffeine on short-burst, anaerobic exercise. Caffeine
Crowe, Melissa, Spinks, Warwick, Leicht, Anthony   +2 more
core  

Risk stratification by pre-operative cardiopulmonary exercise testing improves outcomes following elective abdominal aortic aneurysm surgery : a cohort study [PDF]

, 2013
Background: In 2009, the NHS evidence adoption center and National Institute for Health and Care Excellence (NICE) published a review of the use of endovascular aneurysm repair (EVAR) of abdominal aortic aneurysms (AAAs).
Imray, C. (Chris), Saedon, Mahmud H., Hill, Christopher E., Higman, Daniel, Yow, Heng, Asif Mahmood, Daniel Higman, Watson, Duncan, Dr., Heng Yow, Joanna Shakespeare, Christopher HE Imray, Colette Marshall, Stephen J Goodyear, Shakespeare, Joanna, Goodyear, Stephen J., Mahmood, Asif, Mahmud Saedon, Duncan Watson, Marshall, Colette, Dr., Christopher E Hill   +19 more
core   +1 more source

Effects of all‐out sprint interval training under hyperoxia on exercise performance

Physiological Reports, 2019
All‐out sprint interval training (SIT) is speculated to be an effective and time‐efficient training regimen to improve the performance of aerobic and anaerobic exercises.
Michihiro Kon, Kohei Nakagaki, Yoshiko Ebi   +2 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

A model of heart rate kinetics in response to exercise [PDF]

, 2008
We present a mathematical model, in the form of two coupled ordinary differential equations, for the heart rate kinetics in response to exercise. Our heart rate model is an adaptation of the model of oxygen uptake kinetics of Stirling: a physiological ...
Stirling, James, Zakynthinaki, María S., Refoyo Román, Ignacio, Sampedro Molinuevo, Javier   +3 more
core   +1 more source