Results 71 to 80 of about 101,638 (296)

Effect of Acute L-Carnitine Supplementation on Blood Lactate, Glucose, Aerobic and Anaerobic Performance in Elite Male Artistic Gymnasts

Baltic Journal of Sport and Health Sciences, 2018
Background. Probably L-Carnitine can induce the increase of Pyruvate dehydrogenase activity, decrease of lactic acid production and performance improvements due to the reinforcement of long chain fatty acid oxidation and stabilize of coASH to free COA.
Hamid Arazi, Mohammad Mehrtash
doaj   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Cardiovascular Fitness and Energy Expenditure Response during a Combined Aerobic and Circuit Weight Training Protocol. [PDF]

PLoS ONE, 2016
The present study describes the oxygen uptake and total energy expenditure (including both aerobic and anaerobic contribution) response during three different circuit weight training (CWT) protocols of equivalent duration composed of free weight ...
Pedro J Benito, María Alvarez-Sánchez, Víctor Díaz, Esther Morencos, Ana B Peinado, Rocio Cupeiro, Nicola Maffulli, PRONAF Study Group   +7 more
doaj   +1 more source

Pengaruh Latihan Anaeorobik Terhadap Kelincahan Anak Pada Usia 10-14 Tahun [PDF]

, 2015
Background: The optimized physical condition could be achieved by doing regular physical exercise and doing suitable exercise to develop athelete’s physical condition. One of the components of physical condition is agility.
Adrianto, A.Ari, Basyar , Edwin, Dumi, Afifah Preyanka   +2 more
core  

Efficacy of a four-week uphill sprint training intervention in field hockey players [PDF]

, 2016
Current evidence increasingly suggests that very short, supra-maximal bouts of exercise can have significant health and performance benefits. The majority of research conducted in the area however, uses laboratory-based protocols, which can lack ...
Babraj, John A., Jakeman, John R., McMullan, Judith   +2 more
core   +3 more sources

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

A computational predictor of the anaerobic mechanical power outputs from a clinical exercise stress test.

PLoS ONE, 2023
We previously were able to predict the anaerobic mechanical power outputs using features taken from a maximal incremental cardiopulmonary exercise stress test (CPET).
Efrat Leopold, Tamir Tuller, Mickey Scheinowitz   +2 more
doaj   +1 more source

Pengaruh Latihan Anaerobik Terhadap Kelincahan Pada Anak Usia 10-14 Tahun Studi Pada Anak Usia Dini Di Sekolah Sepak Bola Tugu Muda Semarang [PDF]

, 2015
Background: The optimized physical condition could be achieved by doing regular physical exercise and doing suitable exercise to develop athelete\u27s physical condition. One of the components of physical condition is agility. Agility could be trained by
Adrianto, A. A. (A), Basyar, E. (Edwin), Dumi, A. P. (Afifah)   +2 more
core  

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source