Results 71 to 80 of about 102,240 (346)

A Pilot Study: The Beneficial Effects of Combined Statin-exercise Therapy on Cognitive Function in Patients with Coronary Artery Disease and Mild Cognitive Decline. [PDF]

, 2017
Objective Hypercholesterolemia, a risk factor in cognitive impairment, can be treated with statins. However, cognitive decline associated with "statins" (HMG-CoA reductase inhibitors) is a clinical concern.
Hamada, Mari, Horio, Eiji, Iwasaki, Yuri, Nakamura, Shinichi, Ogawa, Hisao, Oka, Hideki, Rokutanda, Taku, Spin, Joshua M, Sugiyama, Seigo, Toyama, Kensuke, Tsao, Philip S   +10 more
core   +1 more source

Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis

Advanced Science, EarlyView.
This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen, Hao Shi, Junxian He, Ziyu Liu, Yuanyuan Zhu, Xiaoyan Liang, Guihua Liu, Xing Yang   +7 more
wiley   +1 more source

Effect of Acute L-Carnitine Supplementation on Blood Lactate, Glucose, Aerobic and Anaerobic Performance in Elite Male Artistic Gymnasts

Baltic Journal of Sport and Health Sciences, 2018
Background. Probably L-Carnitine can induce the increase of Pyruvate dehydrogenase activity, decrease of lactic acid production and performance improvements due to the reinforcement of long chain fatty acid oxidation and stabilize of coASH to free COA.
Hamid Arazi, Mohammad Mehrtash
doaj   +1 more source

Profiling the sport of stand-up paddle boarding [PDF]

, 2015
Stand-up paddle boarding (SUP) is a rapidly growing activity where only anecdotal evidence exists for its proposed health and fitness benefits.
Climstein, Mike, Hing, Wayne, Schram, Ben   +2 more
core   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Cardiovascular Fitness and Energy Expenditure Response during a Combined Aerobic and Circuit Weight Training Protocol. [PDF]

PLoS ONE, 2016
The present study describes the oxygen uptake and total energy expenditure (including both aerobic and anaerobic contribution) response during three different circuit weight training (CWT) protocols of equivalent duration composed of free weight ...
Pedro J Benito, María Alvarez-Sánchez, Víctor Díaz, Esther Morencos, Ana B Peinado, Rocio Cupeiro, Nicola Maffulli, PRONAF Study Group   +7 more
doaj   +1 more source

Risk stratification by pre-operative cardiopulmonary exercise testing improves outcomes following elective abdominal aortic aneurysm surgery : a cohort study [PDF]

, 2013
Background: In 2009, the NHS evidence adoption center and National Institute for Health and Care Excellence (NICE) published a review of the use of endovascular aneurysm repair (EVAR) of abdominal aortic aneurysms (AAAs).
AR Thompson, BR Baxendale, CP Snowden, DF Reilly, DP Lipkin, DZH Levett, E Kothmann, EL Young, EVAR trial participants, EVAR Trial Participants, H Bengtsson, H Shiels, J Carlisle, JA Franciosa, JD Blankensteijn, JM Prentis, K Henry, K Salatash, K Waxman, KA Eagle, LA Fleisher, N Buck, National Research Ethics Service, P Older, P Older, P Older, PP Goodney, PR Silverstein, R Struthers, RA Hartley, RAP Scott, RR Attia, S Pearson, SM Bauer, SR Finlayson, TB Smith, The UK Small Aneurysm Trial Participants, WC Shoemaker, WL Beaver, WS Aronow   +39 more
core   +2 more sources

Anaerobic Metabolism in Hypertensive Patients During Exercise Stress Test [PDF]

American Journal of Hypertension, 1994
An impaired maximal vasodilating capacity has been reported in hypertensives. This study aimed to assess whether mild hypertensives depend on anaerobic metabolism more than do normal subjects during the exercise stress test. The oxygen uptake (VO2) and carbon dioxide output (VCO2) were measured at the anaerobic threshold (AT) and at peak exercise (VO2p
MODESTI, PIETRO AMEDEO, G. Olivo, F. Pestelli, V. Guarnaccia, GENSINI, GIAN FRANCO, P.L. Malfanti, NERI SERNERI, GIAN GASTONE   +6 more
openaire   +3 more sources

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source

A computational predictor of the anaerobic mechanical power outputs from a clinical exercise stress test.

PLoS ONE, 2023
We previously were able to predict the anaerobic mechanical power outputs using features taken from a maximal incremental cardiopulmonary exercise stress test (CPET).
Efrat Leopold, Tamir Tuller, Mickey Scheinowitz   +2 more
doaj   +1 more source