Results 81 to 90 of about 41,207 (297)

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Randomized controlled study on resistive vibration exercise (EVE Study): protocol, implementation and feasibility [PDF]

, 2013
A training intervention comparing resistance exercise with or without whole-body vibration (WBV) was conducted to compare acute and chronic effects on functional and molecular parameters.
Weber, Tobias, Bloch, W., Zange, Jochen, May, F., Rittweger, Jörn, Rosenberger, André, Mester, J., Beijer, Asa, Schoenau, Eckhardt   +8 more
core  

High-intensity interval exercise training before abdominal aortic aneurysm repair (HIT-AAA): protocol for a randomised controlled feasibility trial [PDF]

, 2014
Introduction: In patients with large abdominal aortic aneurysm (AAA), open surgical or endovascular aneurysm repair procedures are often used to minimise the risk of aneurysm-related rupture and death; however, aneurysm repair itself carries a high risk.
Kerr, K., Kerr, Karen, Weston, Matthew; id_orcid, Tew, G.A., Tew, Garry A, Tew, Garry, Danjoux, Gerard, Batterham, A.M., Batterham, Alan M, Alan M Batterham, Gray, Joanne, Martin, D., Danjoux, Gerard R., Nawaz, Shah, Matthew Weston, Yates, David, Weston, M., Elke Kothmann, Tew, G. A. (Garry), Gerard Danjoux, Gray, J., Weston, Matthew, Yates, D., Garry A Tew, Kothmann, Elke, Martin, Denis, Denis Martin, Martin, Denis; id_orcid, Nawaz, S., Batterham, Alan, Shah Nawaz, Kothmann, E., Joanne Gray, Danjoux, G., David Yates, Karen Kerr   +35 more
core   +1 more source

Wearable Physiological Signals under Acute Stress and Exercise Conditions

Scientific Data
In this work, a novel dataset containing physiological signals recorded non invasevely during structured acute stress induction, as well as aerobic and anaerobic exercise sessions is presented. The physiological data were collected using the Empatica E4,
Andrea Hongn, Facundo Bosch, Lara Eleonora Prado, José Manuel Ferrández, María Paula Bonomini   +4 more
doaj   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Supervised exercise training as an adjunctive therapy for venous leg ulcers: study protocol for a randomised controlled feasibility trial [PDF]

, 2015
Background Venous leg ulcers are common, chronic wounds that are painful and reduce quality of life. Compression therapy is known to assist in the healing of venous leg ulceration.
Gumber, Anil, Michaels, Jonathan, Tew, G.A., Middleton, Geoff, Anil Gumber (3400901), Jonathan Michaels (3400904), Geoff Middleton (3400895), Klonizakis, Markos, Tew, Garry, Garry Tew (3400907), Helen Crank (3400898), Gumber, A., Tew, Garry A., Michaels, J., Crank, H., Klonizakis, M., Crank, Helen, Middleton, G., Markos Klonizakis (3400910)   +18 more
core   +1 more source

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Effects of Blood Flow Restriction and Exercise Intensity on Aerobic, Anaerobic, and Muscle Strength Adaptations in Physically Active Collegiate Women

Frontiers in Physiology, 2019
The purpose of this study was to compare the effects of different combinations of blood flow restriction (BFR) pressure and exercise intensity on aerobic, anaerobic, and muscle strength adaptations in physically active collegiate women. Thirty-two women (
Sadegh Amani-Shalamzari, Saeedeh Rajabi, Hamid Rajabi, Daniel E. Gahreman, Carl Paton, Mahdi Bayati, Thomas Rosemann, Pantelis Theodoros Nikolaidis, Beat Knechtle, Beat Knechtle   +9 more
doaj   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source