Results 1 to 10 of about 261,537 (268)

Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics [PDF]

open access: yesCell Reports, 2019
Summary: The cellular responses induced by mitochondrial dysfunction remain elusive. Intrigued by the lack of almost any glomerular phenotype in patients with profound renal ischemia, we comprehensively investigated the primary sources of energy of ...
Wei Liang   +2 more
exaly   +5 more sources

MEASUREMENT OF ANAEROBIC GLYCOLYSIS IN BRAIN AS RELATED TO POLIOMYELITIS [PDF]

open access: yesJournal of Experimental Medicine, 1945
Experiments with mouse brain, homogenates show that the anaerobic glycolysis of such preparations can be increased tenfold by addition of appropriate coenzymes and phosphate esters. The previously reported alterations in anaerobic glycolysis during poliomyelitis, as measured with low activity preparations, are believed to be of doubtful value in so far
M F, Utter, J M, Reiner, H G, Wood
exaly   +3 more sources

Growth of Oxygen Environment of the Newborn Vocal Fold Maculae Flavae as a Stem Cell Niche [PDF]

open access: yesLaryngoscope Investigative Otolaryngology
Objectives Accumulating evidence indicates that the anterior and posterior maculae flavae of the human vocal fold mucosa function as niches for tissue stem cells.
Kiminori Sato   +5 more
doaj   +2 more sources

Milk-derived exosome-based strategy targeting ferroptosis–glycolysis network promotes bone regeneration in diabetic aging comorbidity [PDF]

open access: yesJournal of Nanobiotechnology
Diabetes and aging synergistically impair bone regeneration, primarily driven by functional deterioration of bone marrow mesenchymal stem cells (BMSCs). Here, we uncover an m6A-centered regulatory network integrating ferroptosis and glycolytic metabolism
Zengguang Wang   +5 more
doaj   +2 more sources

Lactate Metabolism: Separating Correlation From Causation. [PDF]

open access: yesBioessays
Elevated lactate is often interpreted as the cause of pathology, when it more commonly reflects underlying metabolic state. This review separates correlation from causation and highlights how advances in technology have transformed our understanding of lactate biology. ABSTRACT Lactate is among the most frequently measured metabolites in physiology and
Blaze B, Cluntun AA.
europepmc   +2 more sources

NOVEL CORONAVIRUS VULNERABILITY: METABOLIC DERANGEMENTS AND ALTERED DEHYDROGENASE ENZYME ACTIVITIES ARE CENTRAL TO THE VIRUS PATHOGENESIS IN HUMAN, BAT AND OTHER ANIMALS [PDF]

open access: yesExploratory Animal and Medical Research, 2021
The ongoing pandemic of novel coronavirus disease (COVID-19) has killed millions across the globe. This paper hypothesizes anaerobic glycolysis and dehydrogenase enzymes as the focal points of SARS-CoV-2 pathogenesis that ensure virus survival and ...
Sanjib Kumar Manna
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression. [PDF]

open access: yesAnn Clin Transl Neurol
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Yan K   +9 more
europepmc   +2 more sources

Changes in the mRNA expression of glycolysis-related enzymes of Candida albicans during inhibition of intramitochondrial catabolism under anaerobic condition

open access: yesPLoS ONE, 2023
Candida albicans can cause two major types of infections: superficial infection and systemic candidiasis. C. albicans infects diverse host niches, owing to a wide range of virulence factors and attributes, such as morphological transitions and phenotypic
Ken Okabayashi   +7 more
doaj   +2 more sources

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