Results 1 to 10 of about 334,223 (370)

Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics. [PDF]

Cell Rep, 2019
Summary: The cellular responses induced by mitochondrial dysfunction remain elusive. Intrigued by the lack of almost any glomerular phenotype in patients with profound renal ischemia, we comprehensively investigated the primary sources of energy of ...
Brinkkoetter PT, Bork T, Salou S, Liang W, Mizi A, Özel C, Koehler S, Hagmann HH, Ising C, Kuczkowski A, Schnyder S, Abed A, Schermer B, Benzing T, Kretz O, Puelles VG, Lagies S, Schlimpert M, Kammerer B, Handschin C, Schell C, Huber TB.   +21 more
europepmc   +4 more sources

Enhancement of anaerobic glycolysis - a role of PGC-1α4 in resistance exercise. [PDF]

Nat Commun, 2022
Resistance exercise training (RET) is an effective countermeasure to sarcopenia, related frailty and metabolic disorders. Here, we show that an RET-induced increase in PGC-1α4 (an isoform of the transcriptional co-activator PGC-1α) expression not only ...
Koh JH, Pataky MW, Dasari S, Klaus KA, Vuckovic I, Ruegsegger GN, Kumar AP, Robinson MM, Nair KS.   +8 more
europepmc   +4 more sources

LncRNA-DANCR Interferes With miR-125b-5p/HK2 Axis to Desensitize Colon Cancer Cells to Cisplatin vis Activating Anaerobic Glycolysis. [PDF]

Front Oncol, 2020
Colon cancer is one of the most prevalent malignancies that lead to high occurrence of cancer-related deaths. Currently, chemotherapies and radiotherapies remain the primary treatments for advanced colon cancer.
Shi H, Li K, Feng J, Liu G, Feng Y, Zhang X.   +5 more
europepmc   +4 more sources

Low-dose YC-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis. [PDF]

Sci Rep, 2017
This study aimed to establish a therapeutic strategy targeting hypoxic cancer cells in gastric carcinoma (GC). YC-1 is a HIF-1α inhibitor, and we revealed that low-dose YC-1 (10 µM) suppressed HIF-1α expression, and induced hypoxia-dependent apoptosis in
Wakiyama K, Kitajima Y, Tanaka T, Kaneki M, Yanagihara K, Aishima S, Nakamura J, Noshiro H.   +7 more
europepmc   +4 more sources

Thermogenic protein UCP1 and UCP3 expression in non-small cell lung cancer: relation with glycolysis and anaerobic metabolism

Cancer Biology & Medicine, 2017
Uncoupling protein 1 (UCP1) is a proton transporter/channel residing on the inner mitochondrial membrane and is involved in cellular heat production. Using immunohistochemistry, we investigated the expression of UCP1 and UCP3 in a series of 98 patients ...
Alexandra Giatromanolaki, Konstantina Balaska, Dimitra Kalamida, Christos Kakouratos, Efthimios Sivridis, Michael I. Koukourakis   +5 more
doaj   +4 more sources

Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and cell proliferation in endometriosis. [PDF]

Cell Death Dis, 2022
Endometriosis (EM) is one of the vanquished wonted causes of chronic pelvic sting in women and is closely associated with infertility. The long-term, complex, systemic, and post-treatment recurrence of EM wreaks havoc on women’s quality of life ...
Lu C, Qiao P, Fu R, Wang Y, Lu J, Ling X, Liu L, Sun Y, Ren C, Yu Z.   +9 more
europepmc   +2 more sources

Dexmedetomidine alleviated neuropathic pain in dorsal root ganglion neurons by inhibition of anaerobic glycolysis activity and enhancement of ROS tolerance. [PDF]

Biosci Rep, 2020
Neuropathic pain is a kind of chronic pain that is triggered or caused primarily by damage to the nervous system and neurological dysfunction. It’s known that dexmedetomidine is a new type of highly selective alpha2-adrenoceptor agonist with sedation ...
Liu P, Chen T, Tan F, Tian J, Zheng L, Deng Y, Chen J, Chi X.   +7 more
europepmc   +2 more sources

Upregulation of Krebs cycle and anaerobic glycolysis activity early after onset of liver ischemia. [PDF]

PLoS One, 2018
The liver is a highly vascularized organ receiving a dual input of oxygenated blood from the hepatic artery and portal vein. The impact of decreased blood flow on glucose metabolism and how hepatocytes could adapt to this restrictive environment are ...
Chan TS, Cassim S, Raymond VA, Gottschalk S, Merlen G, Zwingmann C, Lapierre P, Darby P, Mazer CD, Bilodeau M.   +9 more
europepmc   +2 more sources

Hyper- and hypo- nutrition studies of the hepatic transcriptome and epigenome suggest that PPARα regulates anaerobic glycolysis. [PDF]

Sci Rep, 2017
Diet plays a crucial role in shaping human health and disease. Diets promoting obesity and insulin resistance can lead to severe metabolic diseases, while calorie-restricted (CR) diets can improve health and extend lifespan.
Soltis AR, Motola S, Vernia S, Ng CW, Kennedy NJ, Dalin S, Matthews BJ, Davis RJ, Fraenkel E.   +8 more
europepmc   +2 more sources

ANAEROBIC GLYCOLYSIS IN AMPHIBIAN DEVELOPMENT. HOMOGENATES

The Biological Bulletin, 1964
1. Freshly prepared homogenates of R. pipiens embryos contain considerable amounts of lactic acid, aerobically produced from an unknown source. The amount present is an increasing function of the age of the embryos from which the homogenates are made.2. In the presence of suitable exogenous substrates, anaerobic homogenates of R.
Mary Ann Parker, John R. Gregg, Jane J. Macisaac   +2 more
openaire   +5 more sources