Results 1 to 10 of about 307,991 (286)

Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics [PDF]

Cell Reports, 2019
Summary: The cellular responses induced by mitochondrial dysfunction remain elusive. Intrigued by the lack of almost any glomerular phenotype in patients with profound renal ischemia, we comprehensively investigated the primary sources of energy of ...
Paul T. Brinkkoetter, Tillmann Bork, Sarah Salou, Wei Liang, Athanasia Mizi, Cem Özel, Sybille Koehler, H. Henning Hagmann, Christina Ising, Alexander Kuczkowski, Svenia Schnyder, Ahmed Abed, Bernhard Schermer, Thomas Benzing, Oliver Kretz, Victor G. Puelles, Simon Lagies, Manuel Schlimpert, Bernd Kammerer, Christoph Handschin, Christoph Schell, Tobias B. Huber   +21 more
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Thermogenic protein UCP1 and UCP3 expression in non-small cell lung cancer: relation with glycolysis and anaerobic metabolism

Cancer Biology & Medicine, 2017
Uncoupling protein 1 (UCP1) is a proton transporter/channel residing on the inner mitochondrial membrane and is involved in cellular heat production. Using immunohistochemistry, we investigated the expression of UCP1 and UCP3 in a series of 98 patients ...
Alexandra Giatromanolaki, Konstantina Balaska, Dimitra Kalamida, Christos Kakouratos, Efthimios Sivridis, Michael I. Koukourakis   +5 more
doaj   +4 more sources

Enhancement of anaerobic glycolysis – a role of PGC-1α4 in resistance exercise [PDF]

Nature Communications, 2022
Resistance exercise training (RET) is an effective countermeasure to sarcopenia, related frailty and metabolic disorders. Here, we show that an RET-induced increase in PGC-1α4 (an isoform of the transcriptional co-activator PGC-1α) expression not only ...
Jin‐Ho Koh, Mark W. Pataky, Surendra Dasari, Katherine A. Klaus, Ivan Vučković, Gregory N. Ruegsegger, Arathi Prabha Kumar, Matthew M. Robinson, K. Sreekumaran Nair   +8 more
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ANAEROBIC GLYCOLYSIS IN AMPHIBIAN DEVELOPMENT. HOMOGENATES

The Biological Bulletin, 1964
1. Freshly prepared homogenates of R. pipiens embryos contain considerable amounts of lactic acid, aerobically produced from an unknown source. The amount present is an increasing function of the age of the embryos from which the homogenates are made.2. In the presence of suitable exogenous substrates, anaerobic homogenates of R.
Mary Ann Parker, John R. Gregg, Jane J. Macisaac   +2 more
openaire   +5 more sources

Changes in the mRNA expression of glycolysis-related enzymes of Candida albicans during inhibition of intramitochondrial catabolism under anaerobic condition

PLoS ONE, 2023
Candida albicans can cause two major types of infections: superficial infection and systemic candidiasis. C. albicans infects diverse host niches, owing to a wide range of virulence factors and attributes, such as morphological transitions and phenotypic
Ken Okabayashi, Hitomi Ogawa, Yuto Hirai, Kureha Nagata, Yukiko Sato, Takanori Narita, Kazuo Satoh, Koichi Makimura   +7 more
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LncRNA-DANCR Interferes With miR-125b-5p/HK2 Axis to Desensitize Colon Cancer Cells to Cisplatin vis Activating Anaerobic Glycolysis [PDF]

Frontiers in Oncology, 2020
Colon cancer is one of the most prevalent malignancies that lead to high occurrence of cancer-related deaths. Currently, chemotherapies and radiotherapies remain the primary treatments for advanced colon cancer.
Huijuan Shi, Kejun Li, Jinxin Feng, Gaojie Liu, Yanlin Feng, Xiangliang Zhang   +5 more
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Untargeted Metabolomics Reveals Anaerobic Glycolysis as a Novel Target of the Hepatotoxic Antidepressant Nefazodone [PDF]

Journal of Pharmacology and Experimental Therapeutics, 2020
Mitochondrial damage is considered a hallmark of drug-induced liver injury (DILI). However, despite the common molecular etiology, the evolution of the injury is usually unpredictable, with some cases that are mild and reversible upon discontinuation of ...
E.I. Krajnc, Michele Visentin, Zhibo Gai, Bruno Stieger, Sophia L. Samodelov, Stéphanie Häusler, Gerd A. Kullak‐Ublick   +6 more
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Anaerobic Activation of Glycolysis in Tumour Tissue [PDF]

Nature, 1932
ROSENTHAL1 has shown that when the anaerobic conversion of fructose to lactic acid by the Jensen rat sarcoma is studied by Warburg's method, a spontaneous increase in the rate of acid production , which he ascribes to the anaerobic formation of an activator, occurs about forty minutes after the manometric vessels are put into the thermostat at 38° C ...
Frank Dickens, G. D. Greville
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Low-dose YC-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis [PDF]

Scientific Reports, 2017
This study aimed to establish a therapeutic strategy targeting hypoxic cancer cells in gastric carcinoma (GC). YC-1 is a HIF-1α inhibitor, and we revealed that low-dose YC-1 (10 µM) suppressed HIF-1α expression, and induced hypoxia-dependent apoptosis in
Kota Wakiyama, Yoshihiko Kitajima, Tomokazu Tanaka, Masao Kaneki, Kazuyoshi Yanagihara, Shinichi Aishima, Jun Nakamura, Hirokazu Noshirο   +7 more
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In vitro inhibition of anaerobic glycolysis by phenothiazine ataractic drugs [PDF]

Experientia, 1960
Im Gegensatz zu Feststellungen anderer Forscher hemmten Chlorpromazin und zwei strukturell verwandte ataraktisch wirkende Phenothiazinderivate die anaerobe Glykolyse von homogenisiertem Rattenhirn. Der Nachweis dieser Hemmung bedarf einer langeren Inkubation, was auf die Mitwirkung eines zeitbedingten Vorgangs, wie metabolische Umwandlung der ...
James A. Buzard
openaire   +3 more sources