Results 11 to 20 of about 71,054 (269)
Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells [PDF]
, 2017 Glioblastoma (GBM) stem cells (GSCs) reside in both hypoxic and vascular microenvironments within tumors. The molecular mechanisms that allow GSCs to occupy such contrasting niches are not understood.
et al,, Si, Sheng
core +6 more sources
, 2010 African trypanosomes have emerged as promising unicellular model organisms for the next generation of systems biology. They offer unique advantages, due to their relative simplicity, the availability of all standard genomics techniques and a long history
BARBARA M. BAKKER +10 more
core +13 more sources
Metabolic Switch and Cytotoxic Effect of Metformin on Burkitt Lymphoma
Frontiers in Oncology, 2021 Altered cellular energetic metabolism has recently emerged as important feature of neoplastic cells. Indeed, interfering with cancer cell metabolism might represent a suitable therapeutic strategy.
Irene Bagaloni +23 more
doaj +1 more source
Explicit consideration of topological and parameter uncertainty gives new insights into a well-established model of glycolysis [PDF]
, 2013 Previous models of glycolysis in the sleeping sickness parasite Trypanosoma brucei assumed that the core part of glycolysis in this unicellular parasite is tightly compartimentalized within an organelle, the glycosome, which had previously been shown to ...
Achcar +30 more
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Early pH Changes in Musculoskeletal Tissues upon Injury-Aerobic Catabolic Pathway Activity Linked to Inter-Individual Differences in Local pH [PDF]
, 2020 Local pH is stated to acidify after bone fracture. However, the time course and degree of acidification remain unknown. Whether the acidification pattern within a fracture hematoma is applicable to adjacent muscle hematoma or is exclusive to this ...
Berkmann, Julia C. +8 more
core +2 more sources
iScience, 2022 Summary: In this study, we explore the role of nuclear survivin in maintaining the effector phenotype of IFNγ-producing T cells acting through the transcriptional control of glucose utilization.
Malin C. Erlandsson +11 more
doaj +1 more source
Synaptic modifications transform neural networks to function without oxygen
BMC Biology, 2023 Background Neural circuit function is highly sensitive to energetic limitations. Much like mammals, brain activity in American bullfrogs quickly fails in hypoxia.
Lara Amaral-Silva, Joseph M. Santin
doaj +1 more source
Cardiosphere-derived cells demonstrate metabolic flexibility that Is influenced by adhesion status [PDF]
, 2017 Adult stem cells demonstrate metabolic flexibility that is regulated by cell adhesion status. The authors demonstrate that adherent cells primarily utilize glycolysis, whereas suspended cells rely on oxidative phosphorylation for their ATP needs.
Abraham, M. Roselle +13 more
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ANAEROBIC GLYCOLYSIS OF THE BRAIN IN EXPERIMENTAL POLIOMYELITIS [PDF]
Journal of Experimental Medicine, 1945 The rate of anaerobic glycolysis of brain tissue was compared for normal animals and animals with experimentally induced poliomyelitis, using two different strains of mice and two different procedures. The report of interference of poliomyelitis with anaerobic glycolysis of brain was not confirmed.
H G, Wood, I I, Rusoff, J M, Reiner
openaire +2 more sources
Frontiers in Plant Science, 2023 Viruses often establish their own infection by altering host metabolism. How viruses co-opt plant metabolism to support their successful infection remains an open question.
Tong Jiang +12 more
doaj +1 more source