Results 21 to 30 of about 314,893 (262)

Milk-derived exosome-based strategy targeting ferroptosis–glycolysis network promotes bone regeneration in diabetic aging comorbidity [PDF]

Journal of Nanobiotechnology
Diabetes and aging synergistically impair bone regeneration, primarily driven by functional deterioration of bone marrow mesenchymal stem cells (BMSCs). Here, we uncover an m6A-centered regulatory network integrating ferroptosis and glycolytic metabolism
Zengguang Wang, Haiyang Lin, Yuntao Li, Yiming Li, Chen Xu, Yaokai Gan   +5 more
doaj   +2 more sources

Correction: Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and cell proliferation in endometriosis [PDF]

Cell Death and Disease
Chao Lu, Pengyun Qiao, Ruihai Fu, Yadi Wang, Jiayi Lu, Xi Ling, Lu Liu, Yujun Sun, Chune Ren, Zhenhai Yu   +9 more
doaj   +2 more sources

Metabolomic Signatures of Longevity in Bivalves Reveal Reorganization of TCA Cycle and Amino Acid Metabolism. [PDF]

Aging Cell
Targeted metabolomics of gill and mantle tissues from five marine bivalve species spanning lifespans from approximately 30 to over 500 years revealed longevity‐associated metabolic signatures. Longer‐lived species exhibited reduced free amino acid pools, lactate, pyruvate‐related ratios, fumarate and malate, alongside increased succinate‐to‐fumarate ...
Bertrand P, Chevret CJL, Rodríguez E, Lemieux H, Blier PU.   +4 more
europepmc   +2 more sources

Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP production [PDF]

, 2011
Recent experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP.
Alexei Vazquez, Zoltan Oltvai, Zoltan N. Oltvai   +2 more
core   +3 more sources

Integration between Glycolysis and Glutamate-Glutamine Cycle Flux May Explain Preferential Glycolytic Increase during Brain Activation, Requiring Glutamate

Frontiers in Integrative Neuroscience, 2017
The 1988 observation by Fox et al. (1988) that brief intense brain activation increases glycolysis (pyruvate formation from glucose) much more than oxidative metabolism has been abundantly confirmed.
Leif Hertz, Ye Chen
doaj   +1 more source

Anaerobic membrane bioreactors for municipal wastewater treatment [PDF]

, 2006
Anaerobic treatment has historically been considered unsuitable for the treatment of domestic wastewaters. The work presented in this thesis focuses on the incorporation of membranes into the anaerobic bioreactor to uncouple solid retention time and ...
Fawehinmi, Folasade
core   +3 more sources

Survivin promotes a glycolytic switch in CD4+ T cells by suppressing the transcription of PFKFB3 in rheumatoid arthritis

iScience, 2022
Summary: In this study, we explore the role of nuclear survivin in maintaining the effector phenotype of IFNγ-producing T cells acting through the transcriptional control of glucose utilization.
Malin C. Erlandsson, Karin M.E. Andersson, Nina Y. Oparina, Venkataragavan Chandrasekaran, Tibor Saghy, Anastasios Damdimopoulos, Maria-Jose Garcia-Bonete, Zakaria Einbeigi, Sofia T. Silfverswärd, Marcela Pekna, Gergely Katona, Maria I. Bokarewa   +11 more
doaj   +1 more source

Thermogenic protein UCP1 and UCP3 expression in non-small cell lung cancer: relation with glycolysis and anaerobic metabolism

Cancer Biology & Medicine, 2017
Uncoupling protein 1 (UCP1) is a proton transporter/channel residing on the inner mitochondrial membrane and is involved in cellular heat production. Using immunohistochemistry, we investigated the expression of UCP1 and UCP3 in a series of 98 patients ...
Alexandra Giatromanolaki, Konstantina Balaska, Dimitra Kalamida, Christos Kakouratos, Efthimios Sivridis, Michael I. Koukourakis   +5 more
doaj   +1 more source

Molecular crowding defines a common origin for the Warburg effect in proliferating cells and the lactate threshold in muscle physiology [PDF]

, 2011
Aerobic glycolysis is a seemingly wasteful mode of ATP production that is seen both in rapidly proliferating mammalian cells and highly active contracting muscles, but whether there is a common origin for its presence in these widely different systems is
Vazquez, Alexei, Oltvai Zoltán N., Vazquez, A, Zoltán N Oltvai, Alexei Vazquez, Vazquez Alexei, Oltvai, ZN, Oltvai, Zoltán N., Zoltán N. Oltvai   +8 more
core   +2 more sources

Sugarcane mosaic virus orchestrates the lactate fermentation pathway to support its successful infection

Frontiers in Plant Science, 2023
Viruses often establish their own infection by altering host metabolism. How viruses co-opt plant metabolism to support their successful infection remains an open question.
Tong Jiang, Tong Jiang, Kaitong Du, Pei Wang, Xinhai Wang, Lianyi Zang, Dezhi Peng, Xi Chen, Geng Sun, Hao Zhang, Zaifeng Fan, Zhiyan Cao, Tao Zhou   +12 more
doaj   +1 more source