Results 21 to 30 of about 261,537 (268)

Synaptic modifications transform neural networks to function without oxygen

BMC Biology, 2023
Background Neural circuit function is highly sensitive to energetic limitations. Much like mammals, brain activity in American bullfrogs quickly fails in hypoxia.
Lara Amaral-Silva, Joseph M. Santin
doaj   +1 more source

Limits and Tradeoffs in the Control of Autocatalytic Systems [PDF]

, 2013
Despite the complexity of biological networks, we find that certain common architectures govern network structures. These architectures impose fundamental constraints on system performance and create tradeoffs that the system must balance in the face of ...
Chandra, Fiona Adriani
core   +1 more source

Integration between Glycolysis and Glutamate-Glutamine Cycle Flux May Explain Preferential Glycolytic Increase during Brain Activation, Requiring Glutamate

Frontiers in Integrative Neuroscience, 2017
The 1988 observation by Fox et al. (1988) that brief intense brain activation increases glycolysis (pyruvate formation from glucose) much more than oxidative metabolism has been abundantly confirmed.
Leif Hertz, Ye Chen
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Sugarcane mosaic virus orchestrates the lactate fermentation pathway to support its successful infection

Frontiers in Plant Science, 2023
Viruses often establish their own infection by altering host metabolism. How viruses co-opt plant metabolism to support their successful infection remains an open question.
Tong Jiang, Tong Jiang, Kaitong Du, Pei Wang, Xinhai Wang, Lianyi Zang, Dezhi Peng, Xi Chen, Geng Sun, Hao Zhang, Zaifeng Fan, Zhiyan Cao, Tao Zhou   +12 more
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Mutated FANCA Gene Role in the Modulation of Energy Metabolism and Mitochondrial Dynamics in Head and Neck Squamous Cell Carcinoma

Cells, 2022
Fanconi Anaemia (FA) is a rare recessive genetic disorder characterized by a defective DNA repair mechanism. Although aplastic anaemia is the principal clinical sign in FA, patients develop a head and neck squamous cell carcinoma (HNSCC) with a frequency
Nadia Bertola, Paolo Degan, Enrico Cappelli, Silvia Ravera   +3 more
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Dynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolism [PDF]

, 2012
Kinetic models of metabolism require detailed knowledge of kinetic parameters. However, due to measurement errors or lack of data this knowledge is often uncertain.
Achcar, Fiona,, Kerkhoven Eduard J., Barrett, M.P., Breitling, Rainer, Breitling, R., Fiona Achcar, Breitling, Rainer,, Bakker, Barbara M.; id_orcid, Achcar, Fiona, Achcar, F., Eduard J. Kerkhoven (187101), Fiona Achcar (187100), Breitling Rainer, Bakker Barbara M., SilicoTryp Consortium, Barrett, Michael P., Rainer Breitling (4371), Michael P Barrett, Bakker, B.M., Barbara M. Bakker (102159), Barrett, Michael P.,, Bakker, Barbara M., Barbara M Bakker, Kerkhoven, Eduard J, Matthews, Keith; id_orcid, Kerkhoven, Eduard J.,, Bakker, Barbara M, Rainer Breitling, Barrett, Michael P, Kerkhoven, E.J., ?, ?, Eduard J Kerkhoven, Achcar Fiona, Barrett Michael P., Bakker, Barbara M.,, Kerkhoven, Eduard J., Michael P. Barrett (167748)   +36 more
core   +6 more sources

Synthesis and application of (18F) fluorodeoxyglucose in oncology diagnosis

Journal of Education, Health and Sport, 2017
[18F] Fluorodeoxyglucose ([18F] FDG) is the most commonly used radiopharmaceutical in clinical positron emission tomography (PET) in oncology. Cancer cells create their own specific microenvironment to survive and grow.
Mateusz Wędrowski, Paweł Waśniowski, Ewelina Wędrowska, Elżbieta Piskorska, Jolanta Czuczejko, Bogdan Małkowski, Walery Żukow   +6 more
doaj   +3 more sources

NLRP3 inflammasome blocked the glycolytic pathway via targeting to PKLR in arsenic-induced hepatic insulin resistance

Ecotoxicology and Environmental Safety, 2021
Arsenic exposure is related to insulin resistance (IR). However, the underlying mechanism is still uncertain. NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasome is a key driving factor of IR.
Jingyuan Zhang, Tianming Qiu, Liping Jiang, Ningning Wang, Yuhan Zhu, Rushan Yan, Shengyu Wang, Jie Bai, Xiaoxia Shi, Guang Yang, Xiaofang Liu, Xiaofeng Yao, Xiance Sun   +12 more
doaj   +1 more source

Glycolysis process activation in preserved red blood cells by nanotechnological treatment of resuspending solutions

Regulatory Mechanisms in Biosystems, 2023
Currently, the use of nanotechnology opens up new opportunities to influence the processes of anaerobic glycolysis and the activity of hexose monophosphate reactions in preserved erythrocytes.
A. N. Belousov, E. I. Malygon, T. O. Kalynychenko, E. Y. Belousova, V. V. Yavorskiy, M. Y. Anoshyna   +5 more
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Astrocyte Elevated Gene-1 Mediates Glycolysis and Tumorigenesis in Colorectal Carcinoma Cells via AMPK Signaling

Mediators of Inflammation, 2014
To investigate the role of AEG-1 in glycolysis and tumorigenesis, we construct myc-AEG-1 expression vector and demonstrate a novel mechanism that AEG-1 may increase the activity of AMPK by Thr172 phosphorylation.
Hong-tao Song, Yu Qin, Guo-dong Yao, Zhen-nan Tian, Song-bin Fu, Jing-shu Geng   +5 more
doaj   +1 more source