Selective advantage of aerobic glycolysis over oxidative phosphorylation [PDF]
The utilization of glycolysis in aerobic conditions have been a subject of debate for more than a century. A hypothesis supported by previous data is that glycolysis has a higher rate of ATP production per protein mass and per occupied volume than oxidative phosphorylation (OxPhos).
arxiv
A major goal of modern computational biology is to simulate the collective behaviour of large cell populations starting from the intricate web of molecular interactions occurring at the microscopic level.
Airley R+26 more
core +1 more source
Modelling energy metabolism dysregulations in neuromuscular diseases: A case study of calpainopathy
Biological modelling helps understanding complex processes, like energy metabolism, by predicting pathway compensations and equilibrium under given conditions.
Camille Siharath+2 more
doaj
Eccentric Cycling Training Improves Erythrocyte Antioxidant and Oxygen Releasing Capacity Associated with Enhanced Anaerobic Glycolysis and Intracellular Acidosis. [PDF]
Huang YC+5 more
europepmc +1 more source
The Effect of Environmental Factors on the Nitrate and Nitrite Metabolism of Oral Actinomyces and Schaalia Species. [PDF]
ABSTRACT Actinomyces naeslundii and Schaalia odontolytica belong to the most predominant nitrite‐producing bacteria in the oral microbiome. Nitrite has antibacterial and vasodilatory effects that may contribute to maintaining oral and systemic health. We have previously elucidated the metabolic characteristics of the nitrite‐producing activity of oral ...
Otake T+6 more
europepmc +2 more sources
Alternative NAD(P)H dehydrogenase and alternative oxidase: proposed physiological roles in animals [PDF]
The electron transport systems in mitochondria of many organisms contain alternative respiratory enzymes distinct from those of the canonical respiratory system depicted in textbooks.
Gospodaryov, Dmytro V.+1 more
core +1 more source
The gut microbiota regulates lipid metabolism of Gansu zokor (Eospalax cansus) through the bile acid pathway in hypoxic environments, reflecting the unique survival strategy of subterranean rodents to maintain lipid metabolism homeostasis and flexible energy metabolism in hypoxic environments.
Maohong Yang+5 more
wiley +1 more source
Self-organization and fractality created by gluconeogenesis in the metabolic process [PDF]
Within a mathematical model, the process of interaction of the metabolic processes such as glycolysis and gluconeogenesis is studied. As a result of the running of two opposite processes in a cell, the conditions for their interaction and the self-organization in a single dissipative system are created.
arxiv
Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs+12 more
wiley +1 more source
Numerical simulation of growth of Escherichia coli in unsaturated porous media [PDF]
A model for the aerobic and anaerobic growth of Escherichia coli (HB101 K12 pGLO) depending on the concentration of oxygen and DOC as substrate has been developed based on laboratory batch experiments. Using inverse modelling to obtain optimal sets of parameters, it could be shown that a model based on a modified double Contois kinetic can predict cell
arxiv