Results 181 to 190 of about 335,029 (357)

Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research

British Journal of Clinical Pharmacology, EarlyView.
Aerospace medicine required controlled terrestrial models to investigate influences of altered atmosphere conditions, such as hypoxia, on human health and performance. These models could potentially be expanded to encompass disease conditions or treatment targets regulated through hypoxia or hypercapnia.
Titiaan E. Post, Cayla Denney, Adam Cohen, Jens Jordan, Ulrich Limper   +4 more
wiley   +1 more source

Genomic Inference of the Metabolism and Evolution of the Archaeal Phylum Aigarchaeota [PDF]

, 2018
Microbes of the phylum Aigarchaeota are widely distributed in geothermal environments, but their physiological and ecological roles are poorly understood.
Castelle, Cindy J., Hedlund, Brian P., Hua, Zheng-Shuang, Knight, Rob, Li, Wen-Jun, Li, Yu-Xian, Liu, Lan, Qi, Yan-Ling, Qu, Yan-Ni, Rao, Yang-Zhi, Shu, Wen-Sheng, Tian, Ye, Yin, Yi-Rui, Zhou, En-Min, Zhu, Qiyun   +14 more
core   +2 more sources

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

Stimulation of glycolysis in anaerobic elongation of pondweed (Potamogeton distinctus) turions [PDF]

, 2002
Takuya Sato
openalex   +1 more source

TRANS-VALVULAR UNLOADING REDUCES ANAEROBIC GLYCOLYSIS BEFORE REPERFUSION AND PRESERVES ENERGY SUBSTRATE UTILIZATION AFTER REPERFUSION IN MODELS OF ACUTE MYOCARDIAL INFARCTION

, 2022
Lija Swain, Xiaoying Qiao, Kay Everett, Shreyas Bhave, Lara Reyelt, Tejasvi Aryaputra, William Surks, Siya Goel, Elric Zweck, Nikolaos Diakos, Navin K. Kapur   +10 more
openalex   +1 more source

Mitonuclear Communication in Stem Cell Function

Cell Proliferation, EarlyView.
In this review, we highlight the critical functions of mitonuclear communication and its impact on mitochondrial proteostasis. Additionally, we examine how mitonuclear signalling influences stem cell function, offering new insights into cellular homeostasis, stem cell therapies, and the potential for lifespan extension.
Baozhou Peng, Yaning Wang, Hongbo Zhang
wiley   +1 more source

Advancements in research on lactate dehydrogenase A in urinary system tumors

BMC Urology
Tumors of the urinary system, such as prostate cancer, bladder cancer, and renal cell carcinoma, are among the most prevalent types of tumors. They often remain asymptomatic in their early stages, with some patients experiencing recurrence or metastasis ...
Zhiyuan Zhuo, Yu Wang, Yifan Xu
doaj   +1 more source

ANAEROBIC GLYCOLYSIS IN NERVOUS TISSUE

Journal of Biological Chemistry, 1945
John M. Reiner, Harland G. Wood, Merton F. Utter   +2 more
openaire   +2 more sources

Exercise Delays Brain Ageing Through Muscle‐Brain Crosstalk

Cell Proliferation, EarlyView.
This graphical abstract illustrates the reciprocal crosstalk between the brain and peripheral organs, highlighting the profound impact of exercise on brain health through systemic interactions. It underscores how exercise influences the brain via signals from various organs and, conversely, how the brain modulates functions of peripheral organs.
Shirin Pourteymour, Rakesh Kumar Majhi, Frode A. Norheim, Christian A. Drevon   +3 more
wiley   +1 more source

Discovery of a novel alpha isoform of the long‐known enzyme LDHA provides new insights into cancer research

The FEBS Journal, EarlyView.
Lactate dehydrogenase A is a key enzyme in energy metabolism, with significant roles in cancer progression. Huang et al. identified LDHAα, a novel LDHA isoform derived from an alternative transcript initiated at AUG198, producing a protein 3 kDa larger than canonical LDHA. LDHAα exhibits enhanced glycolytic activity and promotes glucose uptake, lactate
Wonyoung Park, Shibo Wei, Dongryeol Ryu, Ki‐Tae Ha   +3 more
wiley   +1 more source