Results 231 to 240 of about 345,476 (333)
Journal of Inherited Metabolic Disease, Volume 48, Issue 5, September 2025.ABSTRACT Long‐chain fatty acid oxidation disorders are characterized by rhabdomyolysis, often provoked by physical exercise. For the newborn screening (NBS) cohort, it remains uncertain to what extent they will develop the myopathic phenotype. This study assesses physiological responses to exercise, muscle symptoms, and activity levels in 14 adolescent
Marit Schwantje +6 more
wiley +1 more source
MedComm – Biomaterials and Applications, Volume 4, Issue 3, September 2025.This review highlights pathological features of diabetic wounds, and explores the design principles and therapeutic strategies of smart responsive hydrogels. Importantly, the review evaluates the challenges associated with these technologies and outlines future engineering directions to optimize their clinical adoption.
Jiyuan Du +5 more
wiley +1 more source
THE INHIBITION OF THE ANAEROBIC GLYCOLYSIS OF RAT BRAIN BY ADRENOCHROME
Journal of Biological Chemistry, 1946 openaire +3 more sources
MedComm, Volume 6, Issue 9, September 2025.This study illustrates how high glucose triggers glycolysis, ROS production, and lactic acid accumulation, leading to TXNIP upregulation and PANOptosome formation. These complexes activate apoptosis (cleaved caspase‐3), pyroptosis (GSDME), and necroptosis (MLKL), contributing to diabetic retinopathy.
Xiaoting Xi +8 more
wiley +1 more source
Metabolic Reprogramming: A Crucial Contributor to Anticancer Drug Resistance
MedComm, Volume 6, Issue 9, September 2025.Role of metabolic reprogramming in drug resistance in cancer: Metabolic reprogramming in cancer cells profoundly impacts the responsiveness of these cells to drugs. Cancer cells rewire the flux of the metabolism of the three major nutrients, glucose, lipid, and amino acids, leading to abnormalities in drug orientation, defects in cell death mechanisms,
Yunhan Zhu +7 more
wiley +1 more source
Cellular Senescence in Cancer: Mechanisms, Roles in Tumor Progression, and Therapeutic Implications
MedComm – Oncology, Volume 4, Issue 3, September 2025.Senescent tumor cells in TME exhibit dual roles. “Angels” secrete SASPs/DAMPs to boost immunological clearance and antitumor immunity via MHC‐I upregulation; “Demons” produce tumor‐promoting SASPs recruiting MDSCs to drive malignancy. ABSTRACT Cellular senescence, a state of irreversible cell cycle arrest accompanied by a senescence‐associated ...
Jingrui Yan +5 more
wiley +1 more source