Results 171 to 180 of about 377,158 (236)

Methyl 4‐O‐Demethylbarbatate Destabilises HIF‐1α and Enhances Temozolomide Sensitivity in Glioma Cells

Cell Proliferation, EarlyView.
The lichen‐derived metabolite methyl 4‐O‐demethylbarbatate (Me‐4‐O‐DBA) suppresses glioma stemness, motility, and metabolic plasticity through inhibition of HIF‐1α signaling and synergistically enhances temozolomide activity, highlighting a potential strategy to target stemness‐driven therapeutic resistance in glioma.
Rui Zhou, Mücahit Varlı, Rundong Liu, Jieun Yu, Hyung‐Ho Ha, Jae‐Seoun Hur, Sang Kyum Kim, Hahyun Park, Hangun Kim   +8 more
wiley   +1 more source

Magnesium Enhances Immune Clearance of P. gingivalis in Macrophages by Suppressing MCU‐Mediated Mitochondrial Calcium Overload

Cell Proliferation, EarlyView.
Magnesium restores macrophage clearance of P. gingivalis by inhibiting MCU‐mediated calcium overload. P. gingivalis is mainly phagocytosed by macrophages but escapes intracellular clearance via MCU‐mediated mitochondrial and cytosolic Ca2+ overload in periodontitis. The persistent P.
Dao‐Kun Deng, Meng‐Jie Su, Min‐Yi Zhang, Yu‐Jie Tan, Wenyao Kongling, Hong‐Yu Wang, Mei Xu, Shi‐Yu Liu, Xiao‐Tao He, Fa‐Ming Chen, Bei‐Min Tian, Xuan Li   +11 more
wiley   +1 more source

Common pathways and outliers in glucose catabolism across Trypanosomatidae

The FEBS Journal, EarlyView.
Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes, Mayke B. Alencar, Ariel M. Silber, Ingrid Škodová‐Sveráková, Kristína Záhonová, Vyacheslav Yurchenko   +5 more
wiley   +1 more source

Novel Thermophilic Species of <i>Limisphaera</i> Demonstrate Facultatively Anaerobic Mode of Life and Utilize a Wide Range of Carbohydrates. [PDF]

Life (Basel)
Podosokorskaya OA, Sokolova TG, Zayulina KS, Klyukina AA, Klepikova PR, Novikov AA, Merkel AY, Elcheninov AG.   +7 more
europepmc   +1 more source

Reactive oxygen species, antioxidants and the regulation of plant development

The FEBS Journal, EarlyView.
The regulation of axillary bud outgrowth by the interplay between phytohormone and redox signals. Axillary bud outgrowth is regulated by cellular energy status and the balance between phytohormones, notably abscisic acid (ABA) and gibberellic acid (GA).
Juwita R. Dewi, Christine H. Foyer, Michael J. Considine   +2 more
wiley   +1 more source

Menaquinone biosynthesis in <i>Lactococcus lactis</i>: Recent advances and future prospects. [PDF]

Eng Microbiol
Lou Y, Shuang J, Kong J, Guo T.
europepmc   +1 more source

UbiB proteins mediate an ATP‐dependent decarboxylation step in bacterial ubiquinone biosynthesis

The FEBS Journal, EarlyView.
UbiB proteins are atypical protein kinase‐like enzymes essential for ubiquinone biosynthesis. Here, we demonstrate that bacterial UbiB proteins catalyze the O2‐dependent decarboxylation of ubiquinone precursors, a process linked to their ATPase activity.
Katayoun Kazemzadeh, Bruno Faivre, Sophie‐Carole Chobert, Martial Rey, Sophie S. Abby, Julie Michaud, Tuan‐Anh Dinh, Alexandre Chilin, Olivier Lerouxel, Marc Fontecave, Fabien Pierrel, Murielle Lombard, Ludovic Pelosi   +12 more
wiley   +1 more source

Topographic decoupling of tree-mortality disturbances drives contrasting soil carbon fates via divergent microbial strategies. [PDF]

Nat Commun
Zhang D, Wang Z, Zheng Y, Yin J, Feng Y, Bin Y, Ye Q, Cao H, Lei Y, Zhang B, Zhou J, Ye W, Lian J.   +12 more
europepmc   +1 more source

Anaerobic Attenuation of Diisopropyl Ether (DIPE) in Groundwater: Kinetics and Implications for Monitored Natural Attenuation

Groundwater Monitoring &Remediation, EarlyView.
Abstract Diisopropyl ether (DIPE) is a branched ether used as a solvent, extractant, and gasoline additive. While aerobic biodegradation of DIPE has been documented, attenuation under anaerobic conditions (typical of groundwater impacted by petroleum hydrocarbons and fuel oxygenates) remains poorly constrained.
Sandra Dworatzek, Kawalpreet Kaur, Trevor Carlson, Jennifer Webb, Ioanna Malton, Melody A. Vachon‐Gregory, Lonnie Mercer, Emmanuel Olisa, Eryn Torres, Shailendra Ganna, George Devaull, Joseph Lentini   +11 more
wiley   +1 more source

The physiological response of juvenile diploid and triploid Arctic charr Salvelinus alpinus to exhaustive exercise

Journal of Fish Biology, EarlyView.
Abstract Triploidy is an effective tool for producing sterile fishes but often results in impaired performance in commercial aquaculture. In light of this, our study compared the physiological response to exhaustive exercise in juvenile diploid and triploid Arctic charr Salvelinus alpinus, a polar species with great potential for aquaculture.
John D. Clark, Tillmann J. Benfey
wiley   +1 more source