Results 51 to 60 of about 35,970 (259)

Reimann's "Habitual Hyperthermia" Responding to Hormone Therapy. [PDF]

, 2016
A 25-year-old woman presented with fever of unknown origin, exhibiting malaise and low-grade fevers in evenings. These fevers exhibited a pattern of starting mid-menstrual cycle with resolution around the onset of menses, matching a pattern of "habitual ...
Currier, Judith S, Yang, Otto O
core   +2 more sources

IL-1 Receptor Antagonist Anakinra Inhibits the Effect of IL-1β- Mediated Osteoclast Formation by Periodontal Ligament Fibroblasts

Biology
Rheumatoid arthritis and periodontitis are comorbidities that share mutual pathways. IL-1β is a pro-inflammatory cytokine that plays a crucial role in both diseases.
Elizabeth Steemers, Wael M. I. Talbi, Jolanda M. A. Hogervorst, Ton Schoenmaker, Teun J. de Vries   +4 more
doaj   +1 more source

Expedited Desensitization to Canakinumab

Allergy & Rhinology, 2020
Introduction Interleukin-1 (IL-1) antagonists have been successful in the management of monogenic auto-inflammatory diseases, notably classic hereditary fever syndromes, such as Familial Mediterranean Fever (FMF). Anakinra (Kineret®), a human recombinant
Neha Sanan DO, Jason Schend DO, Marija Rowane OMS-III, Robert Hostoffer DO, FAAFP, FACOP   +3 more
doaj   +1 more source

New insights into the impact of neuro-inflammation in rheumatoid arthritis. [PDF]

, 2014
Rheumatoid arthritis (RA) is considered to be, in many respects, an archetypal autoimmune disease that causes activation of pro-inflammatory pathways resulting in joint and systemic inflammation.
Akasbi, Alten, Askling, Axford, Barrick, Bean, Bekkelund, Bongartz, Burmester, Burmester, Capellino, Cheng, Chiu, Chou, Combs, De Almeida, De Rycke, Detrait, Diamond, Doran, Doran, Emmer, Fayed, Feldmann, Firestein, Franklyn A. Howe, Germano, Gregersen, Gussew, Hamed, Harris, Ho, Hull, Hunter, Inan, Jacobs, Kaltsonoudis, Keane, Keystone, King, Klareskog, Lauvsnes, Lee, Leombruno, Lipsky, Listing, MacGregor, Mahdi, Malaviya, Markenson, McInnes, Medeiros, Mellor, Meseguer, Mikuls, Morris, Nadeau, Ni Mhuircheartaigh, Nicholas R. Fuggle, Nidhi Sofat, Nishioku, Norheim, O'Callaghan, Ogawa, Panayi, Parks, Rachel L. Allen, Ramiro, Rech, Rosenblum, Salliot, Salmon-Ceron, Scher, Schoels, Schweinhardt, Scott, Senaldi, Serrats, Skelly, Smolen, Sokka, Steens, Strangfeld, Symmons, Taylor, Teeling, Thomson, Tracey, Tubach, Upadhyay, van der Woude, van Heemst, van Vollenhoven, Vincent, Wallis, Wartolowska, Wegner, Wellcome Trust Case Control Consortium., Wendler, Weyand, Wolfe, Woolf, Zivadinov   +102 more
core   +2 more sources

Anakinra in Patients With Systemic Juvenile Idiopathic Arthritis: Long-term Safety From the Pharmachild Registry

Journal of Rheumatology, 2022
Objective To evaluate the long-term safety profile of anakinra in patients with systemic juvenile idiopathic arthritis (sJIA). Methods Data from patients with sJIA enrolled in the Pharmachild registry (ClinicalTrials.gov: NCT03932344) prior to September ...
G. Giancane, R. Papa, S. Vastert, F. Bagnasco, J. Swart, P. Quartier, J. Antón, S. Kamphuis, H. Sanner, M. Glerup, F. De Benedetti, E. Tsitsami, A. Remesal, E. Moreno, J. de Inocencio, C. Myrup, C. Pallotti, I. Koné-Paut, K. Franck-Larsson, H. Malmström, Susanna Cederholm, A. Pistorio, N. Wulffraat, N. Ruperto   +23 more
semanticscholar   +1 more source

Anakinra for the treatment of adult secondary HLH: a retrospective experience

International journal of hematology, 2022
Anti-cytokine therapies have been gaining attention as a means of improving outcomes in adult secondary HLH (asHLH), which currently has poor outcomes when treated with standard etoposide-based therapies.
L. Naymagon
semanticscholar   +1 more source

Development and Role in Therapy of Canakinumab in Adult-Onset Still's Disease [PDF]

, 2018
Adult-onset Still's disease (AOSD) is a rare inflammatory disease of unknown etiology typically characterized by episodes of spiking fever, evanescent rash, arthralgia, leukocytosis, and hyperferritinemia. The pivotal role of interleukin (IL)-1 and other
Baggio, Chiara, Bindoli, S, Galozzi, P, Oliviero, F, Sfriso, P   +4 more
core   +1 more source

Anakinra for the Treatment of Hemophagocytic Lymphohistiocytosis: 21 Cases

Journal of Clinical Medicine, 2022
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening cytokine storm syndrome. There are no definitive guidelines for the management of secondary HLH (sHLH).
C. Baverez, M. Grall, Mathieu Gerfaud-Valentin, Sarah De Gail, A. Belot, T. Perpoint, E. Weber, Q. Reynaud, P. Sève, Y. Jamilloux   +9 more
semanticscholar   +1 more source

M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy With Comorbid Traits. [PDF]

Adv Sci (Weinh)
Genes associated with endometriosis risk are highly expressed in M2 macrophages, particularly ligands IL1A and IL1B. Endometrial‐type epithelium and stroma are likely recipients of these ligands. While IL1B treatment disturbs epithelial organization, blockage of the signaling results in a dose‐dependent decrease in spontanesous and evoked pain, reduces
Ochoa S, Rasquel-Oliveira FS, McKinnon B, Haro M, Subramaniam S, Yu P, Coetzee S, Anglesio MS, Wright KN, Meyer R, Porter AE, Gargett CE, Mortlock S, Montgomery GW, Rogers MS, Lawrenson K.   +15 more
europepmc   +2 more sources

Patients Prescribed Anakinra for Acute Gout Have Baseline Increased Burden of Hyperuricemia, Tophi, and Comorbidities, and Ultimate All-Cause Mortality. [PDF]

, 2019
Objective:The interleukin-1 (IL-1) receptor antagonist anakinra is an effective, off-label option in acute gout flares, when conventional therapy options are narrowed.
Pedersen, Brian, Sharma, Ena, Terkeltaub, Robert   +2 more
core