Results 91 to 100 of about 88,414 (237)

Câncer anal e doenças sexualmente transmissíveis: qual a correlação?

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: O Câncer Anal é um tumor raro, cuja incidência é influenciada pelo comportamento sexual. O objetivo do trabalho é verificar a correlação entre o Câncer Anal e as Doenças Sexualmente Transmissíveis, como HPV, HIV, Infecção Gonocócica, Infecção ...
Leonardo de Castro Durães, João Batista de Sousa   +1 more
doaj   +1 more source

Impact of Metformin and Diabetes on Tumor Response to Total Neoadjuvant Therapy in Advanced Rectal Cancer: A Multicenter Retrospective Cohort Study

Asia-Pacific Journal of Clinical Oncology, EarlyView.
In advanced rectal cancer patients receiving total neoadjuvant therapy (TNT), overall tumor response did not differ by diabetes status or metformin use. However, among diabetic patients, metformin use was associated with higher overall complete response rates. These findings suggest a potential benefit of metformin in enhancing TNT response in diabetic
Sergei Bedrikovetski, Mahima Raju, Tracy Fitzsimmons, Ishraq Murshed, Timothy J. Price, Michael Penniment, Sudarsha Selva‐Nayagam, Tarik Sammour   +7 more
wiley   +1 more source

Layer by Layer: The Anatomical ‘Onion Peel’ Approach to Surgery Beyond Total Mesorectal Excision

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background The global incidence of rectal cancer is rising, accompanied by the increasing use of neoadjuvant chemoradiotherapy. Although this approach improves oncological outcomes, it frequently increases operative difficulty during rectal resection.
Sean Davis, Antonio Barbaro, Zachary Bunjo, Sergei Bedrikovetski, Tarik Sammour, Ryash Vather   +5 more
wiley   +1 more source

Seven Years of Watch and Wait With Rectal Cancer—Reflections and Optimisations

ANZ Journal of Surgery, EarlyView.
ABSTRACT Purpose Sir Charles Gairdner Hospital (SCGH) commenced an observation strategy in patients with a complete clinical response, Watch and Wait (W&W), for rectal adenocarcinoma in 2017 using a rigorous surveillance protocol. Our earlier results (2017–2019) have been published.
Ben Finlay, Emma Powell, Anne Long, Rohen White, John Herron, Michael Warner   +5 more
wiley   +1 more source

The use of topical vaginal estrogens in postpartum women: A systematic review

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
A postpartum reduction in circulating estrogen levels, due to antagonism from elevated prolactin levels, further elevated during breastfeeding, can result in pelvic floor dysfunction, including bladder, bowel and sexual dysfunction, pain and implications for perineal wound healing.
Aysha Waheed, Annika Taithongchai, Dudley Robinson   +2 more
wiley   +1 more source

Homozygous Loss‐of‐Function Variant in SLC20A1 Coding for Ubiquitous Phosphate Transporter PiT1 Is Associated With Multiple Developmental Abnormalities

Clinical Genetics, EarlyView.
Biallelic SLC20A1 loss‐of‐function variant causes a previously unrecognized multisystem developmental disorder. We report the first homozygous case presenting with tetralogy of Fallot, renal agenesis, polydactyly, and growth impairment. Transcriptome analysis of patient‐derived fibroblasts suggests significant dysregulation of pathways critical for ...
Eugénie Koumakis, Céline Huber, Wendy Chung, Christine Leroy, Pauline Parisot, Regis Gaudin, Mohamad Zaidan, Valérie Cormier‐Daire, Gérard Friedlander, Yoel Hirsch   +9 more
wiley   +1 more source

HPV42 – a human papillomavirus classified as a low‐risk type with oncogenic potential

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Human papillomavirus (HPV) type 42 is a rare HPV type currently classified as “low‐risk” and belongs to the alpha genus. It has primarily been detected in benign vulvar papillomas and is predominantly associated with benign lesions such as anogenital warts.
Sven Niklas Burmann, Ulrike Wieland, Steffi Silling, Frank Oellig, David Chromy, Julia Hyun, Thilo Gambichler, Alexander Kreuter   +7 more
wiley   +1 more source

Barriers and facilitators to anal cancer screening among men who have sex with men: a systematic review with narrative synthesis

BMC Cancer
Background Increasing trends of anal cancer among men who have sex with men (MSM) highlight the importance of anal cancer screening. However, the screening rate of anal cancer among MSM remains relatively low.
IatTou Sam, Wen Dang, NgaTeng Iu, ZiYue Luo, Yu-Tao Xiang, Robert David Smith   +5 more
doaj   +1 more source

Mucous Membrane Pemphigoid After Anti‐PD‐1 Therapy: Risk‐Stratified Management and Treatment Outcomes

International Journal of Dermatology, EarlyView.
ABSTRACT Mucous membrane pemphigoid (MMP) following anti‐programmed cell death‐1 (PD‐1) therapy is rare but increasingly reported. Management of high‐ and low‐risk MMP in this setting and the potential oncologic trade‐offs remain poorly defined. We performed a narrative synthesis of all published cases of anti‐PD‐1‐associated MMP, following MEDLINE ...
Serena Dienes, Negar Esfandiari, Steven Daveluy   +2 more
wiley   +1 more source

Oral Microbiome in Systemic Autoimmune Diseases: A Systematic Review

Oral Diseases, EarlyView.
ABSTRACT Objective The oral cavity represents a key but underexplored interface between host immunity and microbial communities. The aim of this systematic review was to synthesize current literature on oral microbiota alterations in systemic autoimmune diseases.
Sophie Jung, Eirini Militsi, Olivier Huck   +2 more
wiley   +1 more source