Results 121 to 130 of about 395,234 (289)

Synthesis of Pyrido[2,3‐d]Azolopyrimidinones: Design and Epidermal Growth Factor Receptor‐Targeted Molecular Docking Toward Novel Anticancer Leads

ChemistryOpen, EarlyView.
New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha, Sami A. Al‐Hussain, Basant Farag, AbdElAziz A. Nayl, Wesam Hussein, Abdelwahed R. Sayed, Magdi E. A. Zaki   +6 more
wiley   +1 more source

Factors influencing pathological complete response following neoadjuvant chemoimmunotherapy in locally advanced microsatellite stable colorectal cancer: a retrospective analysis

Frontiers in Medicine
ObjectiveThe purpose of this study is to identify and analyze the factors associated with achieving pathological complete response (pCR) in patients with locally advanced microsatellite stable (MSS) or proficient mismatch repair (pMMR) colorectal cancer ...
Mingxiang Liu, Mingxiang Liu, Qi Zhou, Qi Zhou, Bin Lan, Bin Lan, Jialiang Gan, Jialiang Gan, Sen Zhang, Sen Zhang   +9 more
doaj   +1 more source

The distribution of information for sEMG signals in the rectal cancer treatment process

, 2018
The electrical activity of external anal sphincter can be registered with surface electromyography. This signals are known to be highly complex and nonlinear.
Machura, Lukasz, Nowakowski, Michal, Salowka, Jerzy, Trybek, Paulina   +3 more
core   +1 more source

Hospitalization burden associated with anus and penis neoplasm in Spain (2016-2020)

Human Vaccines & Immunotherapeutics
In 2020, there were approximately 50,865 anal cancer cases and 36,068 penile cancer cases worldwide. HPV is considered the main causal agent for the development of anal cancer and one of the causal agents responsible for the development of penile cancer.
Victor Fernandez-Alonso, Ruth Gil-Prieto, Maria Amado-Anton-Pacheco, Valentín Hernández-Barrera, Ángel Gil-De-Miguel   +4 more
doaj   +1 more source

MRI‐based qualitative, quantitative, and radiomics/deep learning methods for assessing treatment response after neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer

Precision Radiation Oncology, EarlyView.
MRI, owing to its superior soft tissue contrast and spatial resolution, has become the preferred noninvasive modality for assessing nCRT efficacy. This review synthesizes current evidence on MRI‐based assessment of nCRT efficacy in LARC and discusses future directions.
Shuang Chen, Lin Liu, Guangwei Tian, Ruimei Chai   +3 more
wiley   +1 more source

In Vivo Microendoscopy in the Near‐Infrared II Window

Small, EarlyView.
NIR‐II microendoscopy with imaging wavelength extended to 1700 nm, enabling deep intestinal imaging beyond the mucosa and transrectal imaging at cellular resolution without any invasive surgery. It facilitates visualization of the relative motion of vascular networks, lymphatic drainage, and lesions in colitis models, opening new possibilities for ...
Zhisheng Wu, Danyang Xu, Zideng Dai, Xinyuan Wang, Wayne Jason Li, Sixin Xu, Xun Zhang, Yuanhua Liu, Puxian Xiong, Hanze Yu, Wentao Ye, Liangqiong Qu, Yongye Liang, Hongjie Dai, Feifei Wang   +14 more
wiley   +1 more source

Development and validation of a multimodal model based on histopathological and computed tomography imaging for predicting survival outcomes in stage III colorectal cancer

VIEW, EarlyView.
Patients with stage III colorectal cancer exhibit substantial heterogeneity in clinical outcomes despite receiving standardized treatments, which complicates accurate risk stratification. In this study, we integrated features derived from routine histopathological slides and preoperative computed tomography scans using machine learning to develop a ...
Danyi Li, Zhangxin Zhao, Genxia Wei, Weihao Qiu, Zhihao Lin, Jiankun He, Bingbing Li, Jing Wang, Lisheng Zheng, Feiyan Feng, Xiangkun Wu, Zhengyu Zhang, Jinbang Li, Mingxing Qiu, Shujing Guo, Chenglong Zhao, Ying Tan, Yueping Liu, Qingling Zhang, Yu Zhang, Li Liang   +20 more
wiley   +1 more source

Câncer anal e doenças sexualmente transmissíveis: qual a correlação?

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: O Câncer Anal é um tumor raro, cuja incidência é influenciada pelo comportamento sexual. O objetivo do trabalho é verificar a correlação entre o Câncer Anal e as Doenças Sexualmente Transmissíveis, como HPV, HIV, Infecção Gonocócica, Infecção ...
Leonardo de Castro Durães, João Batista de Sousa   +1 more
doaj   +1 more source

Impact of an ERAS‐Based Surgical Care Bundle Implementation for Preventing Anastomotic Leakage in Minimally Invasive Low Anterior Resection for Rectal Cancer: A Retrospective Cohort Study

World Journal of Surgery, EarlyView.
Anastomotic leakage (AL) remains a severe complication after low anterior resection (LAR) for rectal cancer, despite advances in minimally invasive (MI) techniques. This study aimed to evaluate the impact of a surgery‐focused care bundle, implemented on an enhanced recovery after surgery (ERAS)‐based perioperative protocol, on preventing AL and ...
Koji Tamura, Takaaki Fujimoto, Jinghui Zhang, Kinuko Nagayoshi, Yusuke Mizuuchi, Kohei Horioka, Naoki Ikenaga, Kohei Nakata, Kenoki Ohuchida, Masafumi Nakamura   +9 more
wiley   +1 more source

Elevated serum aminotransferases in an infant with failure to thrive: A clinicopathological case report

JPGN Reports, EarlyView.
Jamie M. Klapp, Lauren Nichols, Nicholas J. Gloude, Amber Hildreth, Kathleen B. Schwarz   +4 more
wiley   +1 more source