Results 151 to 160 of about 414,941 (338)

Chromosomal Gains and Losses in Uveal Melanomas Detected by Comparative Genomic Hybridization [PDF]

, 1994
Eleven uveal melanomas were analyzed using comparative genomic hybridization (CGH). The most abundant genetic changes were loss of chromosome 3, overrepresentation of 6p, loss of 6q, and multiplication of 8q.
Becher, Reinhard, Bornfeld, N., Cremer, Thomas, Horsthemke, B., Jauch, Anna, Manoir, Stanislas du, Prescher, G., Speicher, Michael R.   +7 more
core  

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin‐Dependent Kinase 4 Inhibitors

ChemistryOpen, EarlyView.
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda, Sami A. Al‐Hussain, Basant Farag, Mohamed El‐Naggar, Magdi E. A. Zaki, Emad S. A. Alhazmi, Adel S. M. Almohammadi, Sobhi M. Gomha   +7 more
wiley   +1 more source

Clinicopathological Study on Anal Cancer.

, 1992
S Nakae, Tomoaki Urakawa, Kiyoshi Uematsu   +2 more
openalex   +2 more sources

Synthesis of Pyrido[2,3‐d]Azolopyrimidinones: Design and Epidermal Growth Factor Receptor‐Targeted Molecular Docking Toward Novel Anticancer Leads

ChemistryOpen, EarlyView.
New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha, Sami A. Al‐Hussain, Basant Farag, AbdElAziz A. Nayl, Wesam Hussein, Abdelwahed R. Sayed, Magdi E. A. Zaki   +6 more
wiley   +1 more source

Barriers and facilitators to anal cancer screening among men who have sex with men: a systematic review with narrative synthesis

BMC Cancer
Background Increasing trends of anal cancer among men who have sex with men (MSM) highlight the importance of anal cancer screening. However, the screening rate of anal cancer among MSM remains relatively low.
IatTou Sam, Wen Dang, NgaTeng Iu, ZiYue Luo, Yu-Tao Xiang, Robert David Smith   +5 more
doaj   +1 more source

French multicentre clinical evaluation of helical TomoTherapy® for anal cancer in a cohort of 64 consecutive patients [PDF]

, 2015
V. Vendrely, B. Henriques de Figueiredo, E. Rio, J. Benech, S. Belhomme, A. Lisbona, Éric Frison, A. Doussau, N. Nomikossoff, Marc-André Mahé, G. Kantor, J.-P. Maire   +11 more
openalex   +1 more source

Molecular and genomic characterisation of a panel of human anal cancer cell lines [PDF]

, 2021
Glen Guerra, Joseph C. Kong, Rosemary Millen, Matthew Read, David S. Liu, Sara Roth, Shienny Sampurno, Joseph Sia, Maria-Pia Bernardi, Timothy J. Chittleborough, Corina Behrenbruch, Jiasian Teh, Huiling Xu, Nicole M. Haynes, Jiaan Yu, Richard Lupat, David Hawkes, Natasha Di Costanzo, Richard W. Tothill, Catherine Mitchell, Samuel Y. Ngan, Alexander G. Heriot, Robert G. Ramsay, Wayne A. Phillips   +23 more
openalex   +1 more source

Prevalence and associations of larger burden of intra-anal high-grade squamous intraepithelial lesions at baseline in an Australian cohort of gay and bisexual men: The Study of the Prevention of Anal Cancer

, 2020
David J. Templeton, Catherine Williamson, Fengyi Jin, Richard J. Hillman, Jennifer M. Roberts, Carmella Law, Christopher K. Fairley, Suzanne M. Garland, Andrew E. Grulich, I. Mary Poynten   +9 more
openalex   +2 more sources

Emerging Triboelectric Nanogenerators for In‐Body Implantation

Small Methods, EarlyView.
This review explores functional implantable triboelectric nanogenerators in biomedical applications, discussing their mechanisms, electricity generation, and design approaches. To solve postimplantation challenges, four types of triboelectric nanogenerators (TENGs) are introduced: stretchable, bioadhesive, on‐demand biodegradable, and multiresponsive ...
Xiao Xiao, Xiangchun Meng, Yong Hyun Kwon, Yoojin Park, Sang‐Woo Kim   +4 more
wiley   +1 more source

Development and validation of a multimodal model based on histopathological and computed tomography imaging for predicting survival outcomes in stage III colorectal cancer

VIEW, EarlyView.
Patients with stage III colorectal cancer exhibit substantial heterogeneity in clinical outcomes despite receiving standardized treatments, which complicates accurate risk stratification. In this study, we integrated features derived from routine histopathological slides and preoperative computed tomography scans using machine learning to develop a ...
Danyi Li, Zhangxin Zhao, Genxia Wei, Weihao Qiu, Zhihao Lin, Jiankun He, Bingbing Li, Jing Wang, Lisheng Zheng, Feiyan Feng, Xiangkun Wu, Zhengyu Zhang, Jinbang Li, Mingxing Qiu, Shujing Guo, Chenglong Zhao, Ying Tan, Yueping Liu, Qingling Zhang, Yu Zhang, Li Liang   +20 more
wiley   +1 more source