Results 21 to 30 of about 5,821 (197)

Effectiveness of 0.2% Glyceryl trinitrate and 0.5% Nifedipine in the Treatment of Chronic Anal Fissure

Journal of Nepal Medical Association, 2017
Introduction: Anal fissure is an ischemic ulcer caused by combination of spasm of internal anal sphincter and poor blood supply to the posterior midline of anal canal.
Suman Kumar Shrestha, Prabin Bikram Thapa, Dhiresh Kumar Maharjan, Tseten Yonjan Tamang   +3 more
doaj   +1 more source

MEBO versus topical Diltiazem versus a combination of both ointments in the treatment of acute anal fissure: a randomized clinical trial protocol

BMC Complementary Medicine and Therapies, 2021
Background Anal fissure is a common complication of the anorectal region and one of the most reported causes of anal pain. Acute anal fissure can be cured by surgery or medical treatment.
Mohamad Hadi El Charif, Samer Doughan, Rawya Kredly, Sara Kassas, Rayan Azab, Eman Sbaity   +5 more
doaj   +1 more source

Comparison between Lateral Internal Sphincterotomy And Lord’s Operation for Chronic Anal Fissure

Proceedings, 2022
Introduction: Anal fissure is an elongated ulcer in lower anal canal which presents with severe perianal pain during and after defecation with red streaks of blood. Chronic anal fissure is a fissure for more than six weeks with a skin tag (sentinel tag).
Rabeeha Bashir, Mir Jalal-ud-din, Shawana Asad, Sher Ali Khan, Bilawal Gul, Shabeena Naz   +5 more
doaj   +1 more source

An observational study comparing and non-surgical treatment with surgical treatment for chronic anal fissures

Asian Journal of Medical Sciences, 2023
Background: Chronic anal fissure is a common benign anorectal condition that causes significant morbidity. Symptoms consist primarily of pain and bleeding during defecation.
Anupam Banerjee , Pinaki Roy, Rajat Suvra Moral , Swarup Chakraborty   +3 more
doaj   +1 more source

Chronic anal fissure

British Journal of Surgery, 2004
Abstract Background The treatment of chronic anal fissure has shifted in recent years from surgical to medical. Methods A Medline search of studies relevant to modern management of chronic anal fissure was undertaken.
I, Lindsey, O M, Jones, C, Cunningham, N J McC, Mortensen   +3 more
openaire   +2 more sources

Anal Fissure: Is it becoming a medical disorder?

مجله كليه طب الكندي, 2014
An anal fissure which does not heal with conservative measures as sits baths and laxatives is a chronic anal fissure. Physiologically, it is the high resting tone of the internal anal sphincter that chiefly interferes with the healing process of these ...
Ali , Al-shaham, Ali , Al-shaham, Kadhim Jawad,, Serene A.A, MS***   +3 more
doaj   +2 more sources

Therapeutic properties of botulinum toxin on chronic anal fissure treatment and the patient factors role

Journal of Family Medicine and Primary Care, 2020
Background: One of the most frequent distressing diseases which causes anal pain and bleeding after defecation is anal fissure. Despite a poorly understood pathogenesis, the internal anal sphincter spasm has been identified to play a central role in ...
Setareh Soltany, Hamid Reza Hemmati, Jafar Alavy Toussy, Dina Salehi, Parisa Alavi Toosi   +4 more
doaj   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

The Homozygous p.(Arg215Ter) Variant in XRCC2 Is Associated With Atypical Fanconi Anemia Without Major Hematological Abnormalities in Childhood

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Fanconi Anemia (FA) is the most frequent inherited bone marrow failure syndrome. A role for the XRCC2 gene in FA was suspected in 2012 and confirmed in 2016, but only two affected individuals have been described thus far, and no long‐term follow‐up is available.
Sabina Cenciarelli, Giulia Bruna Marchetti, Maria Iascone, Maria Grazia Patricelli, Sara Giangiobbe, Gabriella Cinzia Pozzobon, Miriam Nella Savini, Fabio Giglio, Alessandro Aiuti, Paola Carrera, Francesca Ferrua, Angela Peron   +11 more
wiley   +1 more source

Identification of major congenital malformations based on healthcare databases in France: A proof‐of‐concept study using the epi‐meres nationwide mother–child register

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Besides registries, healthcare databases can provide useful information for assessing the frequency of major congenital malformations (MCMs) and investigating their risk factors, particularly medication exposures. This study aimed to assess the validity of MCMs identification based on French national, comprehensive healthcare databases ...
Tom Duchemin, Lise Marty, Jérôme Drouin, Sara Miranda, Jérémie Botton, Valérie Olié, Alain Weill, Rosemary Dray‐Spira   +7 more
wiley   +1 more source