Results 31 to 40 of about 151,157 (179)

An observational study comparing and non-surgical treatment with surgical treatment for chronic anal fissures

open access: yesAsian Journal of Medical Sciences, 2023
Background: Chronic anal fissure is a common benign anorectal condition that causes significant morbidity. Symptoms consist primarily of pain and bleeding during defecation.
Anupam Banerjee   +3 more
doaj   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

open access: yesAdvanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang   +21 more
wiley   +1 more source

Programmable Guest‐Induced 5‐Phase‐Transition Topological Reconstructions of Cobalt Formate Metal–Organic Frameworks

open access: yesAdvanced Science, EarlyView.
A reversible five‐phase topological cycle is achieved in a minimalist cobalt formate metal–organic framework. The amorphous phase functions as a programmable reactive hub, selectively reconstructing into four distinct crystalline architectures through cationic templates, humidity, or CO2.
Zhiyu Tao   +6 more
wiley   +1 more source

Management of Anal Fissure [PDF]

open access: yes, 2009
Anal fissure is a surgical disease commonly found at outpatients department. The symptoms patients complaint bleeding per rectum, anal pain, skin tag at anal verge, pruritus ani. The history of patients and by physical examination.
Muyphuag, Bunlang
core  

Therapeutic properties of botulinum toxin on chronic anal fissure treatment and the patient factors role

open access: yesJournal of Family Medicine and Primary Care, 2020
Background: One of the most frequent distressing diseases which causes anal pain and bleeding after defecation is anal fissure. Despite a poorly understood pathogenesis, the internal anal sphincter spasm has been identified to play a central role in ...
Setareh Soltany   +4 more
doaj   +1 more source

Asymmetric Structure‐Driven Functional Synergy: A Multistimuli‐Activated Janus Nanomotor for Self‐Amplifying NO Cascade Therapy

open access: yesAdvanced Science, EarlyView.
The Janus nanomotors leverage an “asymmetric structure‐driven functional synergy” strategy to orchestrate spatiotemporally coordinated catalytic functions, in situ self‐amplifying NO generation, and deep tumor penetration, thereby enabling controllable, sustained, and uniform NO generation within the tumor microenvironment.
Chengcheng Li   +6 more
wiley   +1 more source

Assessment of intraspecific skull variation in the Campanian baenid turtle Plesiobaena antiqua

open access: yesThe Anatomical Record, EarlyView.
Abstract Baenids are freshwater paracryptodiran turtles with a fossil record ranging from the Early Cretaceous to the Eocene. The baenid Plesiobaena antiqua is the most common turtle in the Campanian (Late Cretaceous) Dinosaur Park Formation in Canada, but the apparent intraspecific variation remains poorly understood.
Scott Bellotti   +4 more
wiley   +1 more source

Embryonic development of the Mediterranean starfish Hacelia attenuata

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Starfish play essential ecological roles as predators and ecosystem regulators; however, detailed developmental descriptions exist for only a handful of species, none of which are from the Mediterranean Sea. Results In this study, we provide the first full account of the development of the Mediterranean starfish Hacelia attenuata ...
Silvia Caballero‐Mancebo   +3 more
wiley   +1 more source

Front Matter

open access: yesGeophysical Monograph Series, Page i-xiv., 2021

Exploring the links between Large Igneous Provinces and dramatic environmental impact

An emerging consensus suggests that Large Igneous Provinces (LIPs) and Silicic LIPs (SLIPs) are a significant driver of dramatic global environmental and biological changes, including mass extinctions.
wiley  

+1 more source

Congenital Intraoral Synechiae: A Scoping Review of Airway, Feeding, and Surgical Management

open access: yesOtolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To map the existing literature on congenital intraoral synechiae and summarize reported anatomic patterns, clinical presentation, associated anomalies/syndromes, and outcomes to inform standardized diagnostic and therapeutic approaches. Data Sources PubMed, CINAHL, Embase, Web of Science, and Google Scholar were searched from January
Jason Bernier, Mathieu Bergeron
wiley   +1 more source

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