From Executor to Orchestrator: The Pharmacology Scientist in the Age of Agentic AI
Clinical Pharmacology &Therapeutics, EarlyView.Drug development productivity has not improved despite five decades of computational advancement, with the probability that a compound entering Phase I achieving regulatory approval remaining near 10%. Each automation wave increased throughput while leaving the interpretive bottleneck intact; scientists continued to formulate questions, evaluate ...
Michael McCoy, Matthew McCoy
wiley +1 more source
Effect of Oliceridine Fumarate for Patient-Controlled Intravenous Analgesia on Gastrointestinal Function in Laparoscopic Radical Gastrectomy Surgery: A Randomized, Double-Blind, Controlled Trial. [PDF]
Drug Des Devel TherWang C +5 more
europepmc +1 more source
Drug Testing and Analysis, EarlyView.An LC–MS/MS method was developed for the detection of 33 psychoactive medications in cerumen (earwax) and applied to the samples of 60 psychiatric inpatient volunteers. The findings highlighted the utility of cerumen as an innovative biospecimen in clinical toxicological analysis.
Dimitrios Phaedon Kevrekidis +5 more
wiley +1 more source
Comparison of oxycodone hydrochloride injection versus sufentanil for postoperative analgesia in patients undergoing minimally invasive cardiac valve replacement: study protocol for a single-centre, randomised, double-blind non-inferiority trial. [PDF]
BMJ OpenChen X +8 more
europepmc +1 more source
Epilepsia, EarlyView.Abstract Objective Sigma‐1 is a chaperone protein that serves as a key homeostatic regulator, implicated in neuronal excitability and seizure control. Positive allosteric modulators offer a use‐dependent means to enhance Sigma‐1 activity, potentially with favorable tolerability compared to direct agonists.
Eva‐Lotta von Rüden +5 more
wiley +1 more source
Determination of the ED90 for Epidural Hydromorphone and Morphine for Postoperative Pain Using a Biased-Coin Up-and-Down Sequential Design After Elective Cesarean Delivery. [PDF]
Drug Des Devel TherTang X +6 more
europepmc +1 more source
Epilepsia, EarlyView.Abstract Objective Memory problems are comorbid with temporal lobe epilepsy (TLE). Animal models of TLE reveal impairments in spatial firing fields of hippocampal place cells, providing a potential neural substrate for memory problems. Each subfield of the hippocampus carries out unique aspects of spatial memory, yet little is known about how ...
Brittney L. Boublil +4 more
wiley +1 more source
Effect of epileptogenesis on hypercapnic cardioventilatory response in kainic acid rats
Epilepsia, EarlyView.Abstract Objective Cardioventilatory failure is the leading mechanism proposed to underlie sudden unexpected death in epilepsy (SUDEP), which occurs predominantly at night in patients with generalized tonic–clonic seizures. Interictal hypercapnic cardioventilatory responses are suggested to be involved, as they are ablated in chronically epileptic ...
Auriane Apaire +7 more
wiley +1 more source
Comparison of the effects of indomethacin, diclofenac and acetaminophen suppositories on pain score and pethedine usage after cesarean section [PDF]
Background : Cesarean section is one of the common surgeries of women. The rate of cesarean section over the west societies is currently about 14%-15%. In Iran the rate of cesarean section is higher than universal statistics. Acute postoperative pain is
اخوان اکبری, قدرت +2 more
core
Effects of a patient-controlled analgesia pump management model based on a wireless analgesic management system on postoperative pain management in orthopedic patients: a prospective randomized controlled trial protocol. [PDF]
Perioper Med (Lond)Zhang D +6 more
europepmc +1 more source