Amniotic-Fluid Ingestion Enhances\ud Morphine Analgesia During Morphine\ud Tolerance and Withdrawal in Rats [PDF]
Ingestion of placenta and amniotic fluid has been shown to enhance opioid-mediated analgesia in rats produced by morphine injection. footshock, vaginal/cervical stimulation, and during late pregnancy.
Doerr, Jean C., Kristal, Dr. Mark B.
core
NSAIDs attenuate hyperalgesia induced by TRP channel activation
Transient receptor potential (TRP) cation channels have been extensively investigated as targets for analgesic drug discovery. Because some non-steroidal anti-inflammatory drugs (NSAIDs) are structural analogs of prostaglandins (mediators of inflammation)
Ivliane Nozadze+3 more
doaj
Measuring Blood-brain-barrier Permeability Using Evans Blue in Mice
The blood–brain barrier (BBB) is a highly selective permeability barrier that separates the circulating blood from the brain extracellular fluid in the central nervous system.
Jun-Xia Yang, Yan-Yu Jiang, Yu-Bai Guo
doaj +1 more source
Flexible 3D Kirigami Probes for In Vitro and In Vivo Neural Applications
A customizable and scalable approach to fabricate flexible 3D kirigami microelectrode arrays (MEAs) featuring up to 128 shanks, including surface and penetrating electrodes designed to interact with the 3D space of neural tissue, is presented. The 3D kirigami MEAs are successfully deployed in several neural applications, both in vitro and in vivo, and ...
Marie Jung+10 more
wiley +1 more source
A Reinforcement Learning Approach to Weaning of Mechanical Ventilation in Intensive Care Units [PDF]
The management of invasive mechanical ventilation, and the regulation of sedation and analgesia during ventilation, constitutes a major part of the care of patients admitted to intensive care units. Both prolonged dependence on mechanical ventilation and premature extubation are associated with increased risk of complications and higher hospital costs,
arxiv
Local cooling for relieving pain from perineal trauma sustained during childbirth [PDF]
Background: Perineal trauma is common during childbirth and may be painful. Contemporary maternity practice includes offering women numerous forms of pain relief, including the local application of cooling treatments.
Begg, L+4 more
core +1 more source
This study presents an innovative oral microalgae‐based biosystem to inhibit tumor growth, reduce PD‐1 expression, and activate immune responses of hepatocellular carcinoma. When combined with enhanced irreversible electroporation treatment, it demonstrates a synergistic effect that effectively reduces the tumor burden and enhances the tumor immune ...
Cheng Zeng+8 more
wiley +1 more source
Inhalation anesthesia with isoflurane in a black jaguar (Panthera onca) for surgical repair of a fractured mandible [PDF]
A black jaguar (Panthera onca) was anesthetized with a combination of medetomidine, ketamine and isoflurane in oxygen for radiological examination and surgical repair of a fractured mandible.
Bosmans, Tim+4 more
core
Microneedles at the Forefront of Next Generation Theranostics
The TOC figure illustrates the revolutionary role of microneedles in modern medicine, showcasing their dual diagnostic and therapeutic functions. On the left, microneedles access interstitial fluid for real‐time monitoring of biomarkers like glucose and hormones.
Chan Wang+8 more
wiley +1 more source
Visual distortion of body size modulates pain perception [PDF]
Pain is a complex subjective experience, that can be shaped by several cognitive, psychological and even contextual variables. For example, simply viewing the body reduces the reported intensity of acute physical pain.
,+4 more
core +1 more source