Results 21 to 30 of about 235,740 (266)

From Poison to Promise: The Evolution of Tetrodotoxin and Its Potential as a Therapeutic

Toxins, 2021
Tetrodotoxin (TTX) is a potent neurotoxin that was first identified in pufferfish but has since been isolated from an array of taxa that host TTX-producing bacteria.
Gary M. Bucciarelli, Maren Lechner, Audrey Fontes, Lee B. Kats, Heather L. Eisthen, H. Bradley Shaffer   +5 more
doaj   +1 more source

In Vivo, In Vitro and In Silico Study of Cucurbita moschata Flower Extract: A Promising Source of Natural Analgesic, Anti-Inflammatory, and Antibacterial Agents

Molecules, 2023
For thousands of years, medicinal plants have played a pivotal role in maintaining human health and improving the quality of human life. This study was designed to analyze the analgesic, anti-inflammatory, and antibacterial potentials of a hydro ...
Md. Rabiul Hossain, Rashedul Alam, Hea-Jong Chung, Taslima Akter Eva, Mohammed Fazlul Kabir, Husnum Mamurat, Seong-Tshool Hong, Md. Al Hafiz, S. M. Moazzem Hossen   +8 more
doaj   +1 more source

A Steroidal Analgesic

Journal of the American Chemical Society, 1966
SummaryMP-2001, a lower poly alkoxy derivative of estradiol, exhibits analgesic activity in a variety of animal species, including man. MP-2001 does not possess estro-genic activity. It is rapidly excreted from the body without radical change of the basic ste-roidal nucleus.
L R, Axelrod, P N, Rao, D H, Baeder
openaire   +4 more sources

Development and optimisation of novel oral formulation of an opioid analgesic using central composite design

Cogent Medicine, 2017
Introduction of matrix type sustained release systems were a breakthrough for novel oral drug delivery systems. Present research focuses on the development and evaluation of Fentanyl citrate sustained release formulations.
Meenal M. Rane, Amrita Bajaj
doaj   +1 more source

Analgesic and Sedative Effects of Different Doses of Dexmedetomidine Combined with Butorphanol in Continuous Analgesia after a Cesarean Section

Frontiers in Surgery, 2022
ObjectiveThe present study is designed to study the analgesic and sedative effect of different doses of dexmedetomidine combined with butorphanol in continuous analgesia after a cesarean section.MethodsA total of 60 puerperae undergoing a cesarean ...
Hui Liu, Yalin Wang, Fulong Li, Wei Ren, Li Yuan   +4 more
doaj   +1 more source

Endoscopic Foraminotomy for the Treatment of Lumbar Neuro-Foramen Stenosis: Role of CT in Treatment Planning and Post-Operative Assessment

Life
Purpose: to outline the role of CT in pre- and post-treatment evaluation in the case of lumbar endoscopic foraminotomy. Methods: This prospective study, conducted between September 2020 and January 2024, included consecutive patients with clinical ...
Giovanni Foti, Gianluca Tripodi, Giuseppe Ocello, Guglielmo Manenti, Giorgio Merci, Thomas Mignolli, Lorenza Sanfilippo, Massimo Guerriero, Gerardo Serra   +8 more
doaj   +1 more source

The anti-inflammatory and analgesic activities of 2Br-Crebanine and Stephanine from Stephania yunnanenses H. S.Lo

Frontiers in Pharmacology, 2023
Ethnopharmacological relevance: Crebanine (Cre) and Stephanine (Step) are isoquinoline aporphine-type alkaloids that are extracted from Stephania yunnanenses H. S. Lo.
Lili Cui, Chaorui Peng, Jun Li, Xin Cheng, Xiao Fan, Jingyu Li, Zixian Yang, Yuancui Zhao, Yunshu Ma   +8 more
doaj   +1 more source

Multimodal Therapies for the Treatment of Neuropathic Pain: The Role of Lidocaine Patches in Combination Therapy: A Narrative Review

Pain and Therapy
Neuropathic pain (NP) has a population presence of up to 10%. Both systemic agents and topical agents are recommended as first-line therapy for the treatment of NP but monotherapy provides adequate pain relief only in 
Srinivas Nalamachu, Theresa Mallick-Searle, Jeremy Adler, Elaine K. Chan, Wendy Borgersen, Dmitri Lissin   +5 more
doaj   +1 more source

Comparison of antioxidant and analgesic effects of gallic acid and metformin in streptozotocin-induced hyperglycemic rats

مجله دانشگاه علوم پزشکی بیرجند, 2023
Background and Aims: Hyperglycemia is associated with decreased activity of antioxidant enzymes and damage to peripheral nerves. The present study aimed to compare the antioxidant and analgesic effects of gallic acid (a natural compound) with metformin ...
Fatemeh Nohtani, Morteza Behnam Rasouli, Masumeh Kheirabadi   +2 more
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source