Results 251 to 260 of about 225,759 (311)

Analgesic activity of Enhydra fluctuans

Fitoterapia, 2002
The methanol extract of Enhydra fluctuans, given orally at the dose of 250 and 500 mg/kg, was evaluated for its analgesic activity using the acetic acid induced writhing and the tail-flick methods. The extract showed promising activity in both tests.
M T, Rahman, N, Begum, M, Alimuzzaman, M O F, Khan   +3 more
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Analgesic activity of tricyclic antidepressants

Annals of Neurology, 1983
AbstractAmitriptyline (median effective dose {ED50} 1.2 mg per kilogram of body weight), imipramine (ED50 2.3 mg/kg), and their demethylated derivatives nortriptyline (ED50 1.9 mg/kg) and desimipramine (ED50 3.2 mg/kg) are active analgesics as indicated by the mouse writhing assay.
K, Spiegel, R, Kalb, G W, Pasternak
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Plants with central analgesic activity

Phytomedicine, 2001
The present communication constitutes a global review on plant analgesic activity with special emphasis on those found in different parts of the world, including Brazil, which act on the central nervous system. One hundred and sixty six plants belonging to 79 families are reported.
R N, Almeida, D S, Navarro, J M, Barbosa-Filho   +2 more
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Analgesic Activity of Hexaazaisowurtzitane Derivatives

Bulletin of Experimental Biology and Medicine, 2019
Pronounced analgesic activity of the innovative compound 4-(3,4-dibromthiophencarbonyl)-2,6,8,12-tetraacethyl-2,4,6,8,10,12hexaazatetracyclo[5,5,0,03, 11,05, 9] dodecane (thiowurtzine) was observed in the thermal nociceptive hot plate test and in the acute visceral and somatic deep pain model (acetic acid writhing test).
S G, Krylova, T N, Povet'eva, E P, Zueva, N I, Suslov, E N, Amosova, T G, Razina, K A, Lopatina, O Yu, Rybalkina, Yu V, Nesterova, O G, Afanas'eva, E A, Kiseleva, S V, Sysolyatin, D A, Kulagina, V V, Zhdanov   +13 more
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Analgesic activity ofNepeta italica l.

Phytotherapy Research, 1999
A screening study was performed on/by essential oils of Nepeta viscida Boiss and Nepeta italica L. using tail-flick and tail immersion (52.5 degrees C) methods. N. italica samples were collected from three different localities of Turkey. Surprisingly, only one of the essential oils showed significant activity, which was blocked by naloxone, indicating ...
Aydın, Süleyman, Demir, T, Öztürk, Yusuf, Başer, K. Hüsnü Can   +3 more
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Putrescine has analgesic activity, in rats

Life Sciences, 1984
Putrescine, intraperitoneally injected into rats at doses of 200, 300 and 400 mg/Kg, had a dose-dependent analgesic effect (hot plate, 55.5 degrees C), which was not antagonized by naloxone. Analgesia was also obtained by intracerebroventricular injection (1,000 nmoles/rat). Chronic administration (300 mg/Kg/day i.p. for 8 consecutive days) resulted in
GENEDANI, Susanna, PICCININI, Giorgio, BERTOLINI, Alfio   +2 more
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Analgesic activity of Amorphophallus campanulatus tuber

Fitoterapia, 2005
The methanol extract of Amorphophallus campanulatus tuber, given orally at the doses of 250 and 500 mg/kg, showed significant analgesic activity in mice.
J A, Shilpi, P K, Ray, M M, Sarder, S J, Uddin   +3 more
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Conformation-activity relationships of opiate analgesics

Journal of Computer-Aided Molecular Design, 1987
Extensive conformational calculations were performed on the potent opiate analgesics etorphine, PET, R30490 and etonitazene to determine all of their many low-energy conformations. The results were used to characterize four possible models for binding of a simple pharmacophore, comprising two phenyl rings plus a protonated nitrogen, to opiate analgesic
Martin, J, Andrews, P
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Analgesic activity of Calotropis gigantea flower

Fitoterapia, 2007
The alcoholic extract of the flowers of Calotropis gigantea was administered orally and explored for its analgesic activity in chemical and thermal models in mice. In acetic acid induced writhing test, an inhibition of 20.97% and 43.0% in the number of writhes was observed at the doses of 250 and 500 mg/kg, respectively. In the hot plate method the paw
A K, Pathak, A, Argal
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Analgesic activity of anticancer agent suramin

Anti-Cancer Drugs, 1992
Suramin exhibited morphine-like analgesic activity in mice. It antagonized both thermal (hot-plate) and acetic acid-evoked writhing responses with ED50 values 1/100 and 1/68, respectively, that of morphine. The suramin- and morphine-induced hot-plate analgesia was suppressed by administration of 0.5 mg/kg naloxone. However, lower doses (5-30 micrograms/
B T, Ho, Y Y, Huo, J G, Lu, R A, Newman, V A, Levin   +4 more
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