Results 171 to 180 of about 19,751 (211)

Abuse of Non-Narcotic Analgesics

1977
After reports had first been published from Switzerland referring to the abuse of antipyretic analgesics containing phenacetin (Kielholz, 1954; Horrisberger et al., 1958; Battegay, 1958) and to the possibility of a causal connection between such abuse and chronic renal diseases (Spuhler and Zollinger, 1963), numerous authors subsequently drew attention
P. Kielholz, D. Ladewig
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Hepatotoxicity of non-narcotic analgesics

The American Journal of Medicine, 1998
The central role of the liver in drug metabolism sets the stage for drug-related hepatotoxicity. The incidence of hepatotoxicity associated with non-narcotic analgesics is low, but their widespread use both prescription and over-the-counter-makes analgesic-associated hepatotoxicity a clinically and economically important problem.
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Metabolism of the non-narcotic analgesic, Wy-535

Biochemical Pharmacology, 1965
Abstract Hexahydro-1,3-dimethyl-4-phenylazepine-4-14C-carboxylic acid, ethyl ester (Wy-535), was administered to dogs and rats both orally and intramuscularly. Tissue levels were determined in the rat, and plasma levels as well as urinary and fecal excretion rates were determined in both species.
S S, WALKENSTEIN, R A, CORRADINO, R, WISER, C H, GUDMUNDSEN   +3 more
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Non-Narcotic Analgesics — Their use and Abuse

Journal of The Royal Naval Medical Service, 1972
Abstract There is now available a considerable range of non-narcotic analgesics; many are still supplied in the form of compound tablets although true synergy is rare in clinical pharmacology. The value of these analgesics is discussed and their many other uses outlined.
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Non-Narcotics and Co-Analgesics

1984
Aspirin and other non-steroidal antiinflammatory drugs (NSAIDs) and paracetamol are the most important of the non-narcotic analgesics. As simple analgesics they have equal potency but paracetamol is generally better tolerated, particularly with regard to gastrointestinal side-effects1.
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Effects of Non-Narcotic Analgesics on the Liver

Drugs, 1986
Serious hepatotoxicity is uncommon with the proper therapeutic use of non-narcotic analgesics but experience with new non-steroidal anti-inflammatory drugs (NSAIDs) is limited. Drugs such as ibufenac, fenclofenac and benoxaprofen were withdrawn from the market because of hepatotoxicity, and liver damage has been reported on occasion with virtually all ...
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Floctafenine, a new non-narcotic analgesic.

Archives internationales de pharmacodynamie et de therapie, 1975
Floctafenine has been studied in comparison with acetyl-salicylic acid, indomethacin and d-propoxyphene in a series of tests for analgesic and anti-inflammatory activity. It is very active in the acetic acid-induced writhing test and on the inflamed paw in the Randall and Selitto test. Furthermore, like acetylsalicylic acid and indomethacin, but unlike
M, Peterfalvi, R, Deraedt, J, Benzoni, L, Chifflot, R, Fournex   +4 more
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Blockade by l-lysine of non-narcotic analgesics.

The Journal of Pharmacology and Experimental Therapeutics, 1980
The antinociceptive effects of the non-narcotic analgesics clonixin, flunixin, acetylsalicylic acid, aminopyrine and phenylbutazone in the yeast paw test were blocked by l-lysine. Blockade occurred at doses of l-lysine which did not affect pain threshold. The site(s) or mechanism of action of blockade could not be determined with certainty.
L C, Iorio, M, Latranyi, E, Heath, A, Barnett   +3 more
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Effects of Non-Narcotic Analgesics on the Kidney

Drugs, 1986
Non-narcotic analgesics have acute and chronic effects on the kidney. Until quite recently chronic effects have received much more attention than acute effects. Renal papillary necrosis attributed to prolonged intake of analgesic compounds was first described from Switzerland in the 1950s, and subsequently in many countries including Scandinavia ...
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Gastrointestinal Intolerance and Bleeding with Non-Narcotic Analgesics

Drugs, 1986
Aspirin and paracetamol (acetaminophen) are the most commonly used minor analgesics, but their effects on the gastrointestinal tract differ widely. The effects of other nonsteroidal anti-inflammatory drugs (NSAIDs), including phenylbutazone, are intermediate.
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