Results 101 to 110 of about 84,046 (305)

Computational Insights into the Structural Basis for Reduced Hepatotoxicity of Novel Nonopioid Analgesics

ChemMedChem, EarlyView.
Docking and molecular dynamics simulations within CYP2E1 clarify the structural basis for the reduced hepatotoxicity of novel non‐opioid analgesics developed as safer alternatives to acetaminophen. The results reveal that hydrophobicity and substituent size critically influence binding conformations, thereby modulating toxicity.
Claire Coderch, Hernan A. Bazán, Nicolas G. Bazan, Bhattacharjee Surjyadipta, Julio Alvarez‐Builla, Beatriz de Pascual‐Teresa   +5 more
wiley   +1 more source

An inevitable wave of prescription drug monitoring programs in the context of prescription opioids: pros, cons and tensions [PDF]

, 2014
BACKGROUND: In an effort to control non-medical use and/or medical abuse of prescription drugs, particularly prescription opioids, electronic prescription drug monitoring programs (PDMP) have been introduced in North-American countries, Australia and ...
Islam, M. Mofizul, McRae, Ian S.
core   +2 more sources

Evaluation of Therapeutic Opioids in Hair of Neonatal and Pediatric Patients

Drug Testing and Analysis, EarlyView.
This study investigated the incorporation of novel and traditional medically used opioids into the hair of 118 pediatric and neonatal patients. Concentrations (median [range]) in hair were as follows: fentanyl: 4.03 pg/mg [0.10–343], sufentanil: 0.31 pg/mg [0.10–8.64], remifentanil: 0.14 pg/mg [0.10–0.43], and morphine: 27.4 pg/mg [1.0–1870].
Max Polke, Florian Zapf, Tanja Restin, Thomas Kraemer, Tina M. Binz   +4 more
wiley   +1 more source

Intramolecular Heck Reactions of Cyclic Sulfonamides: Regiochemical Trends and Reductive Cleavage

European Journal of Organic Chemistry, EarlyView.
The synthesis of a new class of cyclic sulfonamides and their subsequent conversion into substituted N‐heterocycles is reported. Methyl‐substituted tetrahydropyridine and tetrahydro‐azepine Heck precursors are prepared and cyclized to provide a variety of regioisomeric products.
Hanno Stanley, Anna Tews, Kimberly Geoghegan, Paul Evans   +3 more
wiley   +1 more source

The changing landscape of opioid prescribing: long-acting and extended-release opioid class-wide Risk Evaluation and Mitigation Strategy

Therapeutics and Clinical Risk Management, 2012
Jeffrey A GudinEnglewood Hospital and Medical Center, Englewood, NJ, USAAbstract: Prescriptions for opioid analgesics to manage moderate-to-severe chronic noncancer pain have increased markedly over the last decade, as have postmarketing reports of ...
Gudin JA
doaj  

Opioid analgesics: Managing the predictable

Clinical Medicine
It is imperative for clinicians to understand the common adverse effects of opioid therapy and ensure patients are properly counselled on them prior to opioid initiation. Predictable adverse effects are wide ranging, and include bowel dysfunction, nausea,
A Barnes, G Heppenstall-Harris, A Dickman   +2 more
doaj   +1 more source

Differential Prescribing of Opioid Analgesics According to Physician Specialty for Medicaid Patients with Chronic Noncancer Pain Diagnoses

Pain Research and Management, 2014
BACKGROUND: Despite >20 years of studies investigating the characteristics of patients seeking or receiving opioid analgesics, research characterizing factors associated with physicians’ opioid prescribing practices has been inconclusive, and the role of
Chris Ringwalt, Hallam Gugelmann, Mariana Garrettson, Nabarun Dasgupta, Arlene E Chung, Scott K Proescholdbell, Asheley Cockrell Skinner   +6 more
doaj   +1 more source

The Influence of Gene Polymorphism OPRM1 118A/G on the Perception of Pain and Pharmacodynamics of Narcotic Analgesics

Общая реаниматология, 2014
The polymorphism of μ-opioid receptor is one of the most studied polymorphisms that affect the activity of narcotic analgesics. Despite that there are a large number of publications dealing with the problem, the obtained results are not being currently ...
V. M. Zhenilo, O. A. Makharin
doaj   +1 more source

Modulation of Opioid Transport at the Blood-Brain Barrier by Altered ATP-Binding Cassette (ABC) Transporter Expression and Activity

Pharmaceutics, 2018
Opioids are highly effective analgesics that have a serious potential for adverse drug reactions and for development of addiction and tolerance. Since the use of opioids has escalated in recent years, it is increasingly important to understand biological
Junzhi Yang, Bianca G. Reilly, Thomas P. Davis, Patrick T. Ronaldson   +3 more
doaj   +1 more source

Butorphanol for Post-Operative Analgesia - A Comparative Clinical Study with Ketorolac [PDF]

, 2010
Introduction: Butorphanol, an opioid derivative has been shown to have, in addition to its analgesic properties, several other advantageous effects like antistressor, sedative and anti-shivering action.
Adappa, Karunakara, Kadam, Dinesh, Kadri, Rajani, Koteshwar, Reshma, Mohan, Prashanth, Shenoy, Sunil P, Tantry, Thrivikrama Padur, Vastrad, Nandish S   +7 more
core   +1 more source