Results 111 to 120 of about 86,963 (292)

Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonist [PDF]

, 2013
Since the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles.
Birkás, Erika, Bozó, Beáta, Cinar, Resat, Dochnal, Roberta Beatrix, Fábián, Gabriella, Kicsi, Emese Gabriella, Kékesi, Orsolya, Murányi, Marianna, Mácsai, Mónika, Szabó, Gyula, Szűcs, Mária, Tóth, Géza, Zentai, András   +12 more
core   +3 more sources

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

The Influence of Gene Polymorphism OPRM1 118A/G on the Perception of Pain and Pharmacodynamics of Narcotic Analgesics

Общая реаниматология, 2014
The polymorphism of μ-opioid receptor is one of the most studied polymorphisms that affect the activity of narcotic analgesics. Despite that there are a large number of publications dealing with the problem, the obtained results are not being currently ...
V. M. Zhenilo, O. A. Makharin
doaj   +1 more source

Efficacy of energy‐based devices on episiotomy pain and healing: A systematic review and meta‐analysis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Episiotomy is a common obstetric procedure often associated with significant postpartum pain and delayed wound healing. Conventional treatments provide limited relief and might not be suitable for all women. Energy‐based therapies, including infrared irradiation and low‐level laser therapy (LLLT), a non‐thermal photo biomodulation ...
Shira Regev‐Sadeh, Chen Nahshon, Nadav Cohen, Ofer Lavie, Ariel Zilberlicht   +4 more
wiley   +1 more source

Opioid analgesics: Managing the predictable

Clinical Medicine
It is imperative for clinicians to understand the common adverse effects of opioid therapy and ensure patients are properly counselled on them prior to opioid initiation. Predictable adverse effects are wide ranging, and include bowel dysfunction, nausea,
A Barnes, G Heppenstall-Harris, A Dickman   +2 more
doaj   +1 more source

Differential Prescribing of Opioid Analgesics According to Physician Specialty for Medicaid Patients with Chronic Noncancer Pain Diagnoses

Pain Research and Management, 2014
BACKGROUND: Despite >20 years of studies investigating the characteristics of patients seeking or receiving opioid analgesics, research characterizing factors associated with physicians’ opioid prescribing practices has been inconclusive, and the role of
Chris Ringwalt, Hallam Gugelmann, Mariana Garrettson, Nabarun Dasgupta, Arlene E Chung, Scott K Proescholdbell, Asheley Cockrell Skinner   +6 more
doaj   +1 more source

BIOME cohort: Multi‐system microbiome dynamics and clinical outcomes in massive burn injury patients

iMeta, EarlyView.
Massive burn injuries (MBIs) are associated with high mortality and disability rates, primarily due to microbial‐driven sepsis from extensive skin barrier loss and subsequent scar formation. This makes MBI a compelling model for studying multi‐system microbial dysbiosis following skin barrier destruction.
Runzhi Huang, Yixu Li, Xiaoliang Li, Xulin Chen, Gang Xu, Shurun Huang, Weixi Yang, Xiaodong Li, Haiming Xin, Jianqiang Jiao, Hui Chen, Yuguo Xie, Peng Duan, Wenjun Liu, Xiangdong Deng, Zongyu Li, Yiping Xiu, Jiansheng Zheng, Rujun Chen, Zhaohong Chen, Xingang Wang, Xiaojian Li, Gaoxing Luo, Yi Zhang, Hongyan Zhang, Shichu Xiao, Liang Xiao, Ruijin Guo, Jie Zhang, Xiaofei Ye, Hongtai Tang, Qiao Zuo, Bin Qu, Bingwei Sun, Changhong Lu, Chengliang Deng, Deyi Zheng, Geng Ji, Haisheng Li, Haizhou Yu, Hua Zhou, Jian Wu, Lanjun Nie, Lei Wang, Pihong Zhang, Qingfu Zhang, Shengwu Chao, Sisi Yang, Xianglin Ding, Xiangsheng Ding, Ying Yan, Jiangyong Shen, Yongjian Zhao, Yunchuan Pan, Yunbiao Shen, Yu Zhang, Zhihui Yao, Zhe Cheng, Jiangfan Xie, Zhigang Chu, Shijie Li, Long Xu, Xiuming Yang, Sujie Xie, Hanlin Sun, Shuyuan Xian, Dezhi Han, Maolong Dong, Chengde Xia, Peng Luo, Yongming Yao, Zhaofan Xia, Shizhao Ji   +72 more
wiley   +1 more source

National consumption of opioid and nonopioid analgesics in Croatia: 2007–2013

Therapeutics and Clinical Risk Management, 2015
Darko Krnic,1 Andrea Anic-Matic,2 Svjetlana Dosenovic,2 Pero Draganic,1 Sasa Zezelic,1 Livia Puljak2 1Agency for Medicinal Products and Medical Devices, Zagreb, 2Laboratory for Pain Research, School of Medicine, University of Split, Split, Croatia ...
Krnic D, Anic-Matic A, Dosenovic S, Draganic P, Zezelic S, Puljak L   +5 more
doaj  

Modulation of Opioid Transport at the Blood-Brain Barrier by Altered ATP-Binding Cassette (ABC) Transporter Expression and Activity

Pharmaceutics, 2018
Opioids are highly effective analgesics that have a serious potential for adverse drug reactions and for development of addiction and tolerance. Since the use of opioids has escalated in recent years, it is increasingly important to understand biological
Junzhi Yang, Bianca G. Reilly, Thomas P. Davis, Patrick T. Ronaldson   +3 more
doaj   +1 more source

Brazilian Society of Surgical Oncology: Guidelines and Consensus Statement for Palliative Surgery in Oncology

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objective Palliative surgery in oncology aims to relieve symptoms, improve quality of life, and respect patient autonomy in advanced cancer. This study aimed to develop evidence‐based recommendations for safely indicating and performing palliative surgeries in Brazil, considering clinical, ethical, and multidisciplinary aspects.
Audrey Cabral Ferreira de Oliveira, Jordana Henz Hammes, Isabela Maria Alves de Almeida Oliva, Lara Andrade Mendes Mangieri, Ronald Enrique Delgado Bocanegra, Marcos Gonçalves Adriano Junior, Ana Caroline Fonseca Alves, Eliel Oliveira de Araujo, Jairo Cerqueira de Almeida Teixeira, Patricia Isabel Bahia Mendes Freire, Larissa de Jesus Almeida, Raquel Lacerda Dantas de Farias, Heládio Feitosa e Castro Neto, Alexandre Ferreira Oliveira, Reitan Ribeiro, Rodrigo Nascimento Pinheiro   +15 more
wiley   +1 more source