Results 111 to 120 of about 48,024 (241)

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Evolution of pain management in lung cancer surgery: from opioid-based to personalized analgesia. [PDF]

Anesth Pain Med (Seoul)
Hwang W.
europepmc   +1 more source

Population Pharmacokinetics and Transfer of Gabapentin When Used as a Pain Adjunct for Cesarean Deliveries

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 551-560, March 2025.
ABSTRACT Enhanced Recovery After Surgery (ERAS) protocols for cesarean deliveries (CDs) utilize multimodal pain management strategies that often include gabapentin. While gabapentin is excreted in breast milk, its pharmacokinetics in immediately postpartum lactating women are not known. This observational pharmacokinetic study (NCT05099484) enrolled 21
Rebecca Silvola, Aislinn O'Kane, Michael Heathman, Hannah Marotta, Hayley Trussel, Bobbie Ray, Shelley Dowden, Andrea R. Masters, David M. Haas, Sara K. Quinney   +9 more
wiley   +1 more source

Efficacy of continuous preperitoneal ropivacaine infusion in women with cesarean section: A prospective, randomized controlled, single blinded study

Heliyon
Background: Adequate postoperative pain management after cesarean section is important for the prognosis of both mother and infant. However, excessive prescription of opioid analgesics has become a concern.
Woo Jeng Kim, Eui-Jin Cho, Gyul Jung, In Seon Hwang, Jong Bun Kim, Yoonho Kim, Hee Joung Lee, Yeon-Hee Kim   +7 more
doaj  

Trends in Opioid and Non-opioid Prescriptions in Austria (2016-2021): A Nationwide Study on Utilization and Concomitant Benzodiazepine Use. [PDF]

Pain Ther
Bilir A, Kapral L, Michalek-Sauberer A, Bologheanu R, Gruber F, Kimberger O.   +5 more
europepmc   +1 more source

Drug co‐administration in anesthesia using event‐based MPC

International Journal of Robust and Nonlinear Control, Volume 35, Issue 10, Page 4020-4042, 10 July 2025.
Abstract In this article, a predictive event‐based control architecture for multivariable drug infusion in the anesthesia process is presented. The control scheme considers a multiple‐input single‐output process, where the depth of hypnosis is the controlled variable and the infusion rates of propofol and remifentanil, which are co‐administered by ...
Andrzej Pawłowski, Michele Schiavo, Nicola Latronico, Massimiliano Paltenghi, Antonio Visioli   +4 more
wiley   +1 more source

Postoperative Pain Management With Ketorolac, Acetaminophen, and Gabapentin in Femoral Shaft Fractures: A Prospective Cohort Study. [PDF]

J Am Acad Orthop Surg Glob Res Rev
Hess Arcelay H, Acosta Julbe JI, Claudio-Marcano AM, Cedeño Rodriguez FX, Martinez E, Tresgallo R, Ramirez Lluch N, Lojo-Sojo L.   +7 more
europepmc   +1 more source

Formation of a β‐Endorphin Corona Mitigates Alzheimer's Amyloidogenesis

Small, EarlyView.
This study revealed the molecular mechanism of exercise‐induced β‐endorphin in suppressing the toxicity of Alzheimer's Aβ in vitro, in vivo and in silico. Abstract Senile plaques, comprised of nanosized aggregates of amyloid‐β (Aβ) peptides in the brain, are a pathological hallmark of Alzheimer's disease (AD).
Yunxiang Sun, Nicholas Andrikopoulos, Guofang Zhang, Yuying Liu, Xiufang Liang, Dongjie Li, Xiaoman Suo, Yue Wang, Yuhuan Li, Chuang Wang, Yang Li, Pu Chun Ke, Feng Ding   +12 more
wiley   +1 more source

The impact of opioid analgesics with concomitant antipsychotic use on pain modulation and management in internal medicine: a cross-sequential study protocol. [PDF]

Front Pain Res (Lausanne)
Grignoli N, Livoti S, Greco A, Pironi M, Noseda R, Ceschi A, Garo ML, Gabutti L.   +7 more
europepmc   +1 more source

Abuse of Opioid Analgesics Is Missing [PDF]

Deutsches Ärzteblatt international, 2016
openaire   +4 more sources