Results 111 to 120 of about 84,046 (305)

National consumption of opioid and nonopioid analgesics in Croatia: 2007–2013

open access: yesTherapeutics and Clinical Risk Management, 2015
Darko Krnic,1 Andrea Anic-Matic,2 Svjetlana Dosenovic,2 Pero Draganic,1 Sasa Zezelic,1 Livia Puljak2 1Agency for Medicinal Products and Medical Devices, Zagreb, 2Laboratory for Pain Research, School of Medicine, University of Split, Split, Croatia ...
Krnic D   +5 more
doaj  

A look inside the association codeine-paracetamol: clinical pharmacology supports analgesic efficacy [PDF]

open access: yes, 2015
Acute and chronic pain often requires a multimodal approach. Combination therapy reduces the number of individual daily administrations and improves patient's compliance with the prescribed analgesic treatment. Despite the association codeine/paracetamol
COLUZZI, FLAMINIA, MATTIA, Consalvo
core  

Research progress on the depth of anesthesia monitoring based on the electroencephalogram

open access: yesIbrain, Volume 11, Issue 1, Page 32-43, Spring 2025.
Electroencephalogram (EEG) can noninvasive, continuous, and real‐time monitor the state of brain electrical activity, and the monitoring of EEG can reflect changes in the depth of anesthesia (DOA). The development of artificial intelligence can enable anesthesiologists to extract, analyze, and quantify DOA from complex EEG data.
Xiaolan He, Tingting Li, Xiao Wang
wiley   +1 more source

A Study on the Addictive Feature of Nonsuicidal Self‐Injury in Adolescents With Depression Disorders and Its Correlation With Serum Beta‐Endorphin Concentration and Neural Reward Responsiveness

open access: yesiRADIOLOGY, EarlyView.
NSSI is addictive in adolescents with depression disorders. It may be related to the decrease of serum beta‐endorphin concentration and the activation of brain reward system. ABSTRACT Background Nonsuicidal self‐injury (NSSI) in adolescents with depression disorders often exhibits addictive patterns, potentially linked to serum beta‐endorphin levels ...
Jie Li   +6 more
wiley   +1 more source

A Novel Maturation Equation for Hepatic Clearance Across Preterm, Term Neonates, Children, and Adults: Application to Paracetamol and Its Metabolite

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract A preterm and term neonate to adult (PTNA) maturation equation was introduced recently to describe the glomerular filtration rate maturation from birth to adulthood for neonates of varying gestational age. This study aims to evaluate the newly developed PTNA equation against common maturation approaches like allometric scaling (AS0.75), the ...
Yunjiao Wu   +11 more
wiley   +1 more source

Reversal of Fentanyl‐Induced Respiratory Depression in Healthy Subjects by Intramuscular Nalmefene Administered by Auto‐Injector Versus Intranasal Naloxone

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract As illegally made fentanyl and congeners continue to drive overdose deaths in the US, experts have called for stronger and longer‐lasting antagonists. A randomized, 4‐period, 2‐treatment crossover replicate‐design study in healthy moderately‐experienced opioid users (n = 24) evaluated the reversal of opioid‐induced respiratory depression (OIRD)
Alessandra Cipriano   +4 more
wiley   +1 more source

A pharmacogenetics approach to pain management

open access: yesNeuropsychopharmacology Reports, 2018
Introduction Opioid analgesics are widely used as effective analgesics for the treatment of moderate‐to‐severe pain. However, the analgesic efficacy of opioids is well known to vary widely among individuals, and effective pain treatment is hampered by ...
Kaori Yoshida   +5 more
doaj   +1 more source

Reimagining Outcomes: A Perspective Review of Advances in Remote Monitoring Technologies in Post‐Arthroplasty Patient Care

open access: yesJournal of Orthopaedic Research, EarlyView.
ABSTRACT Arthroplasty surgery is a common and successful end‐stage intervention for advanced osteoarthritis. Yet, postoperative outcomes vary significantly among patients, leading to a plethora of measures and associated measurement approaches to monitor patient outcomes. Traditional approaches rely heavily on patient‐reported outcome measures (PROMs),
Janie L. Astephen Wilson   +1 more
wiley   +1 more source

Opiate, Opioid analgesics and antagonists

open access: yesSemina: Ciências Exatas e Tecnológicas, 2005
Opiate and opioid analgesics are important drugs in the treatment of pain. They are associated with addiction and respiratory depression, side effects which limit their clinical usefulness.
Milton Faccione, Dalva Trevisan Ferreira
doaj  

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