Results 141 to 150 of about 392,664 (239)

Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2.

Journal of Medicinal Chemistry, 2016
Andras Varadi, Gina F. Marrone, Travis C Palmer, Ankita Narayan, M. R. Szabó, Valerie P. Le Rouzic, Steven G. Grinnell, Joan Subrath, Evelyn Warner, Sanjay Kalra, Amanda Hunkele, Jeremy Pagirsky, S. Eans, Jessica M. Medina, Jin Xu, Ying-Xian Pan, A. Borics, G. Pasternak, J. McLaughlin, S. Majumdar   +19 more
semanticscholar   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

A Randomized, Sham‐Controlled Trial of Repetitive Transcranial Magnetic Stimulation Targeting M1 and S2 in Central Poststroke Pain: A Pilot Trial

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Central poststroke pain (CPSP), a neuropathic pain condition, is difficult to treat. Repetitive transcranial magnetic stimulation (rTMS) targeted to the primary motor cortex (M1) can alleviate the condition, but not all patients respond. We aimed to assess a promising alternative rTMS target, the secondary somatosensory cortex (S2),
Juhani Ojala, Jukka Vanhanen, Hanna Harno, Pantelis Lioumis, Selja Vaalto, Mari A. Kaunisto, Jukka Putaala, Marko Kangasniemi, Erika Kirveskari, Jyrki P. Mäkelä, Eija Kalso   +10 more
wiley   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Effect of the rs7858836 Single-Nucleotide Polymorphisms of the ASTN2 Gene on Pain-Related Phenotypes in Japanese Women Who Underwent Laparoscopic Gynecologic Surgery. [PDF]

Neuropsychopharmacol Rep
Inoue R, Nishizawa D, Okahara S, Hara A, Okada H, Hasegawa J, Ebata Y, Nakayama K, Hayashida M, Ikeda K.   +9 more
europepmc   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

Acute Postoperative Pain in Orthopaedic Trauma and Non-Trauma Patients: An Analysis of the China Acute Postoperative Pain Study (CAPOPS). [PDF]

Eur J Pain
Li L, Han S, Zhao F, Yang H, Lv X, Wu J, Hou A, Li F, Hou D, Zhang C, Li H, Li M, Li J, Zhang Z, Wang C, Mi W, Liu Y.   +16 more
europepmc   +1 more source

Polypharmacy and potentially inappropriate prescribing in people with type 2 diabetes: An analysis of the Scottish Diabetes Research Network national diabetes cohort

Diabetic Medicine, EarlyView.
Abstract Aims This study assesses national trends and, socio‐demographic and clinical factors associated with polypharmacy and potentially in appropriate prescribing among people with type 2 diabetes in Scotland from 2012 to 2022. Methods Retrospective cohort study using nationwide data from the Scottish Care Information – Diabetes database ...
William Berthon, Stuart J. McGurnaghan, Luke A. K. Blackbourn, Amanda de Assuncao Santiago Fernandes, Lauren E. Walker, Rory J. McCrimmon, Helen M. Colhoun, David A. McAllister, Peter Hanlon   +8 more
wiley   +1 more source

Profile of analgesic prescription by medical specialties: A comparative study of symptomatic management in emergency care between orthopedics and other specialties-A retrospective observational brief report. [PDF]

PLoS One
Penna LF, Wu AA, Madureira R, Fonseca RLA, Zelada RK, Ganem F, Morinaga CV.   +6 more
europepmc   +1 more source

Compulsive-Like Responding for Opioid Analgesics in Rats with Extended Access

Neuropsychopharmacology, 2015
C. Wade, L. Vendruscolo, J. Schlosburg, D. O. Hernández, G. Koob   +4 more
semanticscholar   +1 more source