Results 161 to 170 of about 373,787 (306)

Structure-based discovery of opioid analgesics with reduced side effects

Nature, 2016
A. Manglik, Henry Lin, Dipendra K. Aryal, J. McCorvy, D. Dengler, G. Corder, A. Levit, Ralf C. Kling, Viachaslau Bernat, H. Hübner, Xi-Ping Huang, M. Sassano, P. Giguère, S. Löber, D. Duan, G. Scherrer, B. Kobilka, P. Gmeiner, B. Roth, B. Shoichet   +19 more
semanticscholar   +1 more source

Transurethral Fulguration of Hunner Lesion Was Effective for Primary Management of Pelvic Pain in Patients With Interstitial Cystitis: A Long‐Term Follow‐Up Study

Neurourology and Urodynamics, EarlyView.
ABSTRACT Objective This study aimed to analyze the outcomes of clinical management of patients with interstitial cystitis (IC). Patients and Methods We retrospectively analyzed the electronic medical records of patients with IC who visited outpatient clinics with pelvic pain between October 2005 and December 2019.
Hyun Ju Jeong, Yu Jin Kang, Min Soo Choo, Seong Jin Jeong, Seung‐June Oh   +4 more
wiley   +1 more source

A Comparison of Veterans with Problematic Opioid Use Identified through Natural Language Processing of Clinical Notes versus Using Diagnostic Codes [PDF]

arXiv
Background: Electronic health records (EHRs) are a data source for opioid research. Opioid use disorder is known to be under-coded as a diagnosis, yet problematic opioid use can be documented in clinical notes. Objectives: Our goals were 1) to identify problematic opioid use from a full range of clinical notes; and 2) to compare the characteristics ...
arxiv  

Low‐value interventions to deimplement: A secondary analysis of a systematic review of low back pain clinical practice guidelines

PM&R, EarlyView.
Abstract Objective To perform a secondary review of low back pain (LBP) clinical practice guidelines (CPG) identified in a recently conducted systematic review and to synthesize and summarize low‐value recommendations as practices that may be candidates for deimplementation.
Daniel Tai, Eunyeop Kim, Prateek Grover, Alejandro Rodriguez, Timothy J. Olivier, Thiru M. Annaswamy   +5 more
wiley   +1 more source

Mobility-GCN: a human mobility-based graph convolutional network for tracking and analyzing the spatial dynamics of the synthetic opioid crisis in the USA, 2013-2020 [PDF]

arXiv
Synthetic opioids are the most common drugs involved in drug-involved overdose mortalities in the U.S. The Center for Disease Control and Prevention reported that in 2018, about 70% of all drug overdose deaths involved opioids and 67% of all opioid-involved deaths were accounted for by synthetic opioids.
arxiv  

Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics

Cell, 2017
Cullen L. Schmid, N. Kennedy, N. Ross, K. Lovell, Zhizhou Yue, J. Morgenweck, Michael D. Cameron, T. Bannister, L. Bohn   +8 more
semanticscholar   +1 more source

The positive significance of staged physical mental combined pain reduction nursing based on pain scoring for cancer pain patient

Precision Medical Sciences, EarlyView.
We found that staged physical‐mental combined pain reducing care based on pain scoring for patients with cancer pain improves living standards of patients, which is better than the normal medication intervention nursing. Abstract To observe the positive of stage‐based physical mental combined pain reduction nursing based on pain scoring for cancer pain
Xiaoqian Shao, Xuan Sun, Qiuyang Chen, Lingyun Shi, Yeping Wang, Xueqin Lv   +5 more
wiley   +1 more source

The Hidden Toll of COVID-19 on Opioid Mortality in Georgia: A Bayesian Excess Opioid Mortality Analysis [PDF]

arXiv
COVID-19 has had a large scale negative impact on the health of opioid users exacerbating the health of an already vulnerable population. Critical information on the total impact of COVID-19 on opioid users is unknown due to a lack of comprehensive data on COVID-19 cases, inaccurate diagnostic coding, and lack of data coverage.
arxiv  

Diet-ODIN: A Novel Framework for Opioid Misuse Detection with Interpretable Dietary Patterns [PDF]

arXiv
The opioid crisis has been one of the most critical society concerns in the United States. Although the medication assisted treatment (MAT) is recognized as the most effective treatment for opioid misuse and addiction, the various side effects can trigger opioid relapse.
arxiv  

Concomitant Use of Etrasimod With Opioids or Antidepressants in Patients With Ulcerative Colitis—A Safety Analysis

United European Gastroenterology Journal, EarlyView.
ABSTRACT Background Etrasimod is an oral, once‐daily (q.d.), selective sphingosine 1‐phosphate (S1P)1,4,5 receptor modulator for the treatment of moderately to severely active ulcerative colitis (UC). Unlike the S1P receptor modulator ozanimod, etrasimod does not have a molecular structure to inhibit monoamine oxidase (MAO).
Anita Afzali, Miguel Regueiro, Andres J. Yarur, Yamile Zabana, Siew C. Ng, Sujatha Menon, Aoibhinn McDonnell, Krisztina Lazin, Michael Keating, Abhishek Bhattacharjee, Diogo Branquinho, Eustratios Bananis, Laurent Peyrin‐Biroulet   +12 more
wiley   +1 more source